I-Glutathione: I-Antioxidant enamandla

●Yintoni iGlutathione ?

I-Glutathione (GSH) yi-tripeptide compound (i-molecular formula C₁₀H₁₇N₃O₆S) eyenziwe yi-glutamic acid, i-cysteine.kunye ne-glycine edibeneyoγ-iibhondi zeamide. Undoqo wayo osebenzayo liqela le-sulfhydryl (-SH) kwi-cysteine, elinika amandla okunciphisa amandla.

Iintlobo ezimbini eziphambili ze-physiological ze-glutathione:

1. Ukunciphisa i-glutathione (GSH): i-akhawunti ngaphezu kwe-90% yesixa esipheleleyo emzimbeni kwaye iyona ndlela iphambili ye-antioxidant kunye nemisebenzi ye-detoxification; isusa ngokuthe ngqo i-radicals yamahhala kwaye ikhusela iiseli kumonakalo we-oxidative.

2. I-glutathione ene-Oxidized (GSSG): eyenziwa yi-oxidation yee-molecule ezimbini ze-GSH (GSSG), kunye nomsebenzi obuthathaka we-physiological; phantsi kwe-catalysis ye-glutathione reductase, kuxhomekeke kwi-NADPH ukuba incitshiswe kwi-GSH ukugcina ibhalansi ye-redox yeselula.

●Ziziphi iiNzuzo zeGlutathione ?

1. Imisebenzi engundoqo yePhysiology

Ukukhutshwa kwetyhefu kunye nokukhusela isibindi:

IGlutathione inako ci-helate metals ezinzima (ilothe, i-mercury), i-toxins yeziyobisi (njenge-cisplatin) kunye ne-alcohol metabolites. I-injection ye-intravenous ye-1800mg / ngosuku inokuphucula kakhulu ukusebenza kwesibindi, kwaye izinga elisebenzayo lokunyanga isifo sesibindi esinxilisayo lingaphezulu kwe-85%.

I-Antiliary anti-tumor:

IGlutathione inako reduce chemotherapy nephrotoxicity, ukwandisa umsebenzi iiseli umbulali zendalo (NK iiseli) ngamaxesha 2, kwaye inhibit ithumba cell oxidative uxinzelelo.

Ukhuseleko lwe-Neurological and ophthalmic:

Glutathione unako rukuphelisa iimpawu zokuqala zesifo sikaParkinson kunye nokunciphisa i-dopamine neurotoxicity; ukusetyenziswa kwendawo yamaconsi kwamehlo kunokulungisa izilonda ze-corneal kunye nokuvimbela ukuphuhliswa kwe-cataract.

2. Impilo kunye nezicelo zobuhle

Ukulawulwa kwe-immune yokuguga: Yenza iprotheni ye-Sirtuins isebenze kwaye ulibazise ukunciphisa i-telomere; ukwandisa umsebenzi we-lymphocyte kunye nokunciphisa ukukhululwa kwezinto ezivuthayo;

Ubumhlophe kunye nokususwa kwamabala: Ukuthintela umsebenzi we-tyrosinase kunye nokunciphisa imveliso ye-melanin. Ingqinwe ngokweklinikhi yokuphucula ukunwebeka kwesikhumba kunye nokunciphisa ubunzulu bemibimbi ngama-40%.

●Yintoni iSicelosKwe Glutathione ?

1. Indawo yezoNyango

Isitofu: isetyenziselwa ukhuseleko lwechemotherapy (1.5g/m² ithamo), uncedo lokuqala lwetyhefu, kwaye kufuneka lugcinwe kude nokukhanya;

Amalungiselelo omlomo: ukusetyenziswa kwexesha elide (200-500mg / ixesha, ngaphezu kweenyanga ze-6) ukunyusa i-GSH yokugcina i-GSH kunye nokuncedisa kunyango lwesifo esingapheliyo sesibindi.

2. Ukutya okuSebenzayo

Izongezelelo ze-Antioxidant: i-vitamin C edibeneyo (i-500mg i-vitamin C ngosuku inokunyusa amanqanaba e-GSH nge-47%) okanye i-selenium yokuphucula i-immunity;

I-Hangover kunye nokutya kokukhusela isibindi: yongezwaglutathionekwiziselo ezisebenzayo ukukhawulezisa imetabolism yotywala kunye nokunciphisa umonakalo wesibindi.

3. I-Cosmetic Innovation

I-Whitening essence: isetyenziswa ngokubanzi kwiimarike zaseAsia ukuvimbela i-melanin, idibaniswe neteknoloji ye-microneedle ukuphucula ukungena kwesikhumba;

Ifomula yokuguga: i-liposome efakwe kwi-GSH ixhathisa umonakalo we-ultraviolet kwaye iyanciphisa i-erythema ye-photoaging nge-31% -46%.

4. Ukusetyenziswa kwe-Emerging Technologies

Ukunikezelwa kweziyobisi ezijoliswe kuyo: I-nanogels ephendula i-GSH ingakwazi ukukhulula ngokulawulwayo iziyobisi ze-chemotherapy (ezifana ne-doxorubicin) kwindawo ye-tumor, ukuphucula ukusebenza kunye nokunciphisa imiphumo emibi;

Ukukhuselwa kwendalo kunye nezolimo: Phuhlisa izinto ezinokubola kwaye ujonge izongezo zesondlo ukomeleza imfuyo kunye neenkukhu.

Ukusuka kwilungelo elilodwa lomenzi wokutsalwa kwegwele ukuya kwimveliso yobunzima yamawaka eetoni kwibhayoloji yokwenziwa namhlanje, inkqubo ye-industrialization ye-glutathione iqinisekise uguqulo "lwe-cell guard" kwi "injini yetekhnoloji". Kwixesha elizayo, ngokugqitywa kokuqinisekiswa kweklinikhi yezibonakaliso ezintsha ze-neuroprotection kunye nokuchasana nokuguga, le molekyuli ye-antioxidant ephethe ubomi iya kuqhubeka nokubonelela ngokukhawuleza kwesayensi kwimpilo yabantu kunye nokuphila ixesha elide. 

●Unikezelo ENTSHAGlutathione Umgubo