I-Chenodeoxycholic Acid: Undoqo weMathiriyeli ekrwada kuNyango lweSifo sesibindi, ukutya okuSebenzayo kunye neBiomaterials

● YintoniI-Chenodeoxycholic Acid ?

I-Chenodeoxycholic Acid (CDCA) yenye yezinto eziphambili ze-vertebrate bile, i-akhawunti ye-30% -40% ye-asidi ye-bile yabantu, kwaye umxholo wayo uphezulu kwi-bile ye-geese, amadada, iihagu kunye nezinye izilwanyana.

Impumelelo kwitekhnoloji yale mihla yokukhupha:

I-Supercritical CO₂ extraction: ukukhutshwa phantsi kweqondo lokushisa eliphantsi kunye neemeko zoxinzelelo oluphezulu ukuphepha ii-residus ze-solvent ye-organic, kunye nokucoceka kunokufikelela ngaphezu kwe-98%;

Indlela ye-Microbial fermentation: usebenzisa iintlobo ze-genetically engineered strains (ezifana ne-Escherichia coli) ukudibanisa i-CDCA, iindleko ziyancipha nge-40%, ehambelana nomkhwa wokuvelisa amayeza ohlaza;

Indlela ye-Chemical synthesis: usebenzisa i-cholesterol njenge-precursor, ifumaneka ngokuphendula kwamanyathelo amaninzi, afanelekileyo kwiimveliso zebakala eliphezulu lokuxutywa kweyeza.

Iimpawu eziphathekayo kunye neekhemikhali zeI-Chenodeoxycholic Acid :
Igama leKhemikhali: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Ifomula yemolekyuli: C₂₄H₄₀O₄
Ubunzima bemolekyuli: 392.58 g/mol
Ukubonakala: umgubo omhlophe wekristale
Ukunyibilika: Inyibilika kancinane emanzini, inyibilika ngokulula kwi-ethanol, ether, kwichloroform
Indawo yokunyibilikisa: 165-168℃
Uzinzo: ubuthathaka ekukhanyeni nakubushushu, kufuneka ifakwe efrijini kude nokukhanya (2-8℃)

● Ziziphi iingenelo zeI-Chenodeoxycholic Acid ?

1. Ukuchithwa kweCholesterol Gallstones

I-Mechanism: inhibit isibindi i-HMG-CoA reductase, ukunciphisa i-cholesterol synthesis, ukukhuthaza ukukhutshwa kwe-bile acid, kwaye ngokuthe ngcembe unyibilikise i-cholesterol gallstones;

Idatha yeklinikhi: I-750mg CDCA ngosuku ngeenyanga ze-12-24, izinga lokuchithwa kwe-gallstone linokufikelela kwi-40% -70%.

2. Unyango lwePrimary Biliary Cholangitis (Pbc)

Amachiza okuqala: I-FDA ivunyiwe i-Chenodeoxycholic Acid CDCA ye-PBC, iphucula izikhombisi zesibindi (ALT / AST iyancipha ngaphezu kwe-50%);

Unyango oludibeneyo: ludibeneI-Chenodeoxycholic Acidkunye ne-ursodeoxycholic acid (UDCA), ukusebenza kuphuculwe ngu-30%.

3. Ukulawulwa kweZifo zeMetabolic

Ukunciphisa i-lipids yegazi: ukunciphisa i-serum epheleleyo ye-cholesterol (TC) kunye ne-low-density lipoprotein (LDL);

I-Anti-diabetes: ukuphucula ubuntununtunu be-insulin, uvavanyo lwezilwanyana lubonisa ukuba iswekile yegazi yehla nge-20%

4. I-Anti-Inflammatory kunye ne-Immune Regulation

Ukuvimbela indlela ye-NF-κB kunye nokunciphisa ukukhululwa kwezinto ezivuthayo (TNF-α, IL-6);

Izilingo zeklinikhi zibonise ukuba izinga lokuphucula i-fibrosis yesibindi kwizigulane ezine-non-alcoholic fatty disease (NAFLD) zidlula i-60%.

● Zithini izicelo zeI-Chenodeoxycholic Acid ?

1. Indawo yezoNyango

Unyango lwe-Gallstone: iipilisi ze-CDCA (250mg / tablet), i-dose yemihla ngemihla 10-15mg / kg;

Unyango lwe-PBC: amalungiselelo ekhompawundi kunye ne-UDCA (efana ne-Ursofalk®), iintengiso zonyaka zehlabathi zidlula i-US $ 500 yezigidi;

Uphando oluchasene ne-tumor: ukuvimbela ukwanda kweeseli zomhlaza wesibindi ngokulawula i-FXR receptors, ukungena kwiSigaba sesi-II solingo lwezonyango.

2. Ukutya okuSebenzayo kunye neeMveliso zeMpilo

Amacwecwe okukhusela isibindi: i-compound formula (CDCA + silymarin), ukunciphisa umonakalo wesibindi esinxilisayo;

Iicapsules zokunciphisa i-Lipid: i-synergistic kunye ne-red yeast yerayisi isicatshulwa sokulawula i-lipid metabolism yegazi.

3. Ukufuywa kwezilwanyana kunye nokuKhuliswa kwezilwanyana zasemanzini

Izongezo zokutya: ukuphucula imfuyo kunye neenkukhu ze-metabolism ye-fat metabolism, ukunciphisa izinga lokutyeba kwesisu;

Impilo yeentlanzi: idibanisa i-0.1%chenodeoxycholic acidukwandisa ukuxhathisa isifo se-carp kunye nokunyusa izinga lokusinda nge-15%.

4. Izithambiso kunye noNonophelo lomntu

I-anti-inflammatory essence: i-0.5% -1% yokudibanisa, ukuphucula i-acne kunye ne-skin sensitivity;

Ukhathalelo lwe-scalp: thintela i-Malassezia kwaye unciphise ukuveliswa kwe-dandruff.

Ukusuka kwi-extraction ye-bile yendabuko ukuya kwi-microbial synthesis, i-chenodeoxycholic acid ifumana utshintsho ukusuka "kwisithako sendalo" ukuya "kwiyeza elichanekileyo". Ngokunzulu kophando kwizifo ze-metabolic kunye ne-anti-tumor, i-CDCA inokuba yeyona nto iphambili yonyango lwesifo sesibindi, ukutya okusebenzayo kunye ne-biomaterials, ekhokelela kumaza amatsha kwishishini lezempilo le-100 leebhiliyoni.

● Unikezelo ENTSHAI-Chenodeoxycholic AcidUmgubo