●Yintoni i I-Caffeic Acid?
I-Caffeic acid, igama lekhemikhali i-3,4-dihydroxycinnamic acid (i-molecular formula C₉H₈O₄, i-CAS No. 331-39-5), i-asidi ye-phenolic yendalo efumaneka ngokubanzi kwizityalo. Yikristale etyheli ngenkangeleko, inyibilika kancinci emanzini abandayo, inyibilika ngokulula emanzini ashushu, i-ethanol kunye ne-ethyl acetate, enendawo yokunyibilika ye-194-213 ℃ (iinkqubo ezahlukeneyo ziyahluka), i-orenji-bomvu kwisisombululo se-alkaline, kunye noluhlaza obumnyama ngokudibana ne-ferric chloride.
Imithombo engundoqo yokutsalwa ibandakanya:
●Izityalo zonyango:I-Asteraceae Solidago, i-sinamoni, i-dandelion (equkethe i-caffeic acid ≥ 0.02%), i-Ranunculaceae Cimicifuga rhizome;
●Imithombo yeziqhamo nemifuno:i-lemon peel, i-blueberry, i-apula, i-broccoli kunye nemifuno ye-cruciferous;
●Izithako zesiselo:iimbotyi zekofu (ngendlela ye-chlorogenic acid esters), iwayini (idibene ne-tartaric acid).
Itekhnoloji yale mihla isebenzisa itekhnoloji ye-CO₂ engaphezulu kakhulu okanye itekhnoloji ye-bio-enzymatic hydrolysis yokucoca i-caffeic acid kwizixhobo ezikrwada zezityalo, ngobunyulu obungaphezulu kwe-98%, ihlangabezana nemigangatho yemigangatho yeyeza kunye ne-cosmetic.
● Ziziphi iingenelo I-Caffeic Acid?
Iasidi yeCaffeic ibonisa imisebenzi emininzi yebhayoloji ngenxa yesakhiwo sayo se-o-diphenolic hydroxyl:
1. I-Antioxidant kunye ne-Anti-Inflammatory:
Inowona mandla anamandla okutshabalalisa i-radical free phakathi kwe-hydrogenated cinnamic acid, kunye nokusebenza kwayo kumaxesha angama-4 kune-vitamin E. Ivimbela i-lipid peroxidation chain reactions ngokwenza izakhiwo zequinone;
Ivimbela i-leukotriene synthesis (ilawula ukugonywa kunye nokuvuvukala), iyanciphisa umonakalo we-DNA we-UV-induced isikhumba, kwaye iyanciphisa i-erythema index nge-50%.
2. Ukhuseleko lweMetabolic kunye neCardiovascular:
Caffeic acidInqanda i-low-density lipoprotein (LDL) i-oxidation kwaye iyanciphisa ukubunjwa kwe-atherosclerotic plaque;
Kwimifuniselo ye-mouse yokutya okunamafutha aphezulu, ukuqokelelwa kwamafutha e-visceral kwehle nge-30% kunye ne-triglycerides yesibindi yehla nge-40%.
3. I-Neuroprotection kunye ne-Anti-Tumor:
Ukwandiswa kwe-insulin ye-hippocampal, ukuphuculwa komsebenzi wememori kwiimodeli zesifo se-Alzheimer, kunye nokunciphisa i-protein ye-β-amyloid;
Inqanda ukwanda kweeseli zomhlaza we-fibrosarcoma kwaye inqanda ukukhula kwe-tumor ngokunciphisa i-DNA methylation.
4. I-Hemostasis kunye neLeukocyte Ukwanda:
Iyancipha i-microvessels kwaye iphucula umsebenzi wezinto ezidibeneyo. Isetyenziswa ngokweklinikhi kwi-hemostasis yotyando kunye ne-leukopenia emva kwechemotherapy, ngesantya esisebenzayo esingaphezulu kwama-85%.
● Zithini izicelo ze I-Caffeic Acid ?
Ukusetyenziswa kwe-caffeic acid kugubungela iinkalo ezininzi:
1. Amayeza:iipilisi ze-caffeic acid (i-hemostasis, ukunyuka kweeseli ezimhlophe zegazi), i-anti-tumor ekujoliswe kuyo (i-succinic acid isigaba II solingo lwezonyango)
2. Izithambiso:i-sunscreen (i-synergistic zinc oxide ukwandisa ixabiso le-SPF), i-whitening essence (inhibit tyrosinase, i-melanin inhibition rate 80%).
3. Ishishini lokutya:izigcini zendalo (ukulibazisa intlanzi lipid oxidation), iziselo ezisebenzayo (i-anti-oxidation kunye ne-anti-inflammatory), ukusetyenziswa kwe-synergistic ye-ascorbic acid
4. ULimo kunye noKhuseleko lokusiNgqongileyo:izitshabalalisi zendalo (inhibit cotton bollworm protease), ukuguqulwa koboya (iipropati ze-antioxidant zonyuke ngama-75%).
●Usetyenziso kunye neMimiselo yoKhuselekoKweI-Caffeic Acid
Umthamo wamayeza:Iipilisi ze-Caffeic acid: 0.1-0.3g kanye, amaxesha ama-3 ngosuku, iintsuku ezili-14 njengekhosi yonyango, ukubalwa kweplatelet kufuneka kubekwe iliso (kuncitshiswe xa> 100×10⁹/L, kufuneka udibane nogqirha ngaphambi kokusetyenziswa);
Contraindications:I-Contraindicated kubafazi abakhulelweyo kunye nezigulane ezine-hypercoagulable state; isetyenziswe ngononophelo kwizigulane ezinokukhubazeka kwesibindi kunye nezilonda zesisu.
Izongezo zokuthambisa:I-0.5% -2% yongezwa kwiimveliso ezimhlophe, zichithwa kwangaphambili kwi-ethanol kwaye zongezwa kwi-matrix enamanzi ukuphepha i-agglomeration.
Iimfuno zokugcina:itywinwe kwindawo emnyama, efrijini kwi-2-8 ℃, esebenzayo iminyaka emi-2 (amalungiselelo olwelo kufuneka akhuselwe kwi-oxidation kunye nokuthotywa)
●Unikezelo ENTSHAI-Caffeic AcidUmgubo
Ixesha lokuposa: Jul-23-2025
