IBilirubin: iNkunkuma yeMetabolic okanye uMlondolozi weMpilo?

●Yintoni i Bilirubin?

I-bilirubin yimveliso yokubola kweeseli ezibomvu zegazi eziguga. Malunga nezigidi ezi-2 zeeseli ezibomvu zegazi ziyaqhekeka kwi-spleen yonke imihla. I-hemoglobin ekhutshiweyo iguqulwa ngokwe-enzymatic ibe yibilirubin engathanga ngqo enyibilikayo, ethi emva koko iguqulwe ibe yibilirubin ethe ngqo enyibilikayo ngamanzi ngesibindi kwaye ekugqibeleni ikhuphelwe emathunjini ngenyongo. Nakuphi na ukungahambi kakuhle kolu luhlu lwemetabolism (efana ne-hemolysis, ukonakala kwesibindi okanye ukuphazamiseka kwe-bile duct) kunokukhokelela ekuqokeleleni kwe-bilirubin kwaye kubangele i-jaundice.

Uphando lwamva nje lufumene ukuba xa i-bilirubin igxininisekile≥17.05μi-mol / L, umbutho phakathi kwesifo sikashukela kunye ne-stroke unokuvalwa, kwaye umngcipheko wokushaywa kwesifo kwizigulane zesifo seswekile zesilisa ziyancipha ngamaxesha angama-2.67. Indlela yokuthintela iprotheni ye-C-reactive ephezulu kunye ne-systemic immune immune index, ukubeka iibhuleki "kwisiphango esivuthayo".

I-Bilirubin ikhutshwa kwisibindi sehagu kunye ne-shark, i-gallbladder yenkomo kunye ne-brainstem. Siphumelele impumelelo ngokusungula izinto ezintsha zobuchwepheshe:

I-Supercritical CO₂ extraction: gcina izithako ezisebenzayo phantsi kwendawo yokushisa ephantsi, ugweme i-residu ye-solvent, kwaye unyuse ubunyulu ngaphezu kwe-98%;

Inkqubo ye-Biological enzymatic hydrolysis: ukuguqulwa kwe-bilirubin glycosides kwi-aglycones esebenzayo, ukwandisa i-bioavailability ngama-50%.

●Ziziphi iingenelo zeBilirubin ?

1. Ukhuseleko lwe-Antioxidant

I-Bilirubin yinto ebalulekileyo ye-antioxidant engapheliyo emzimbeni, enokuthi ithintele ngokufanelekileyo i-radicals yamahhala (efana ne-superoxide kunye ne-hydrogen peroxide) kunye nokunciphisa umonakalo woxinzelelo lwe-oxidative kwiiseli zeseli, iiprotheni kunye ne-DNA. Uphononongo lubonise ukuba ugxininiso oluphantsi lwe-bilirubin lunokuphucula ukhuseleko lweseli kumonakalo we-oxidative ngokuvula iindlela zokubonisa i-antioxidant (ezifana ne-Nrf2 indlela), kwaye inokunciphisa umngcipheko we-atherosclerosis kunye nezifo ze-neurodeergenerative.

2. Umsebenzi we-Immunomodulatory

Bilirubininokulawula iimpendulo ze-immune ngokuthintela ukukhutshwa kwezinto ezivuthayo (ezifana ne-TNF-α kunye ne-IL-6). Inokunciphisa umonakalo kwizicubu ezibangelwa ukuvuvukala okugqithisileyo ngelixa igcina ibhalansi ye-immune system. Ngokomzekelo, i-bilirubin ephakanyiswe kancinci kwi-physiological jaundice yeentsana ezisanda kuzalwa inokunceda ukunciphisa umngcipheko wosulelo ngokusebenzisa le ndlela. Nangona kunjalo, ukugxininiswa okugqithisileyo kunokuthintela umsebenzi weeseli zokuzivikela kunye nokwandisa ukuchaphazeleka kwintsholongwane.

3. Iseli kunye neuroprotection

I-Bilirubin inempembelelo ekhethekileyo yokukhusela kwi-nervous system. Iyakwazi ukuwela umqobo wegazi-ingqondo kwaye ikhusele i-neurons kwi-ischemia okanye izilonda eziphazamisayo ngokuvimbela i-glutamate excitotoxicity kunye nokunciphisa umonakalo owenziwe nge-oxidative. Ukongezelela, i-bilirubin inokunciphisa umonakalo weeseli zesibindi, iiseli ze-myocardial, njl. phantsi kwe-hypoxia okanye i-toxin exposure, kunye nokugcina umsebenzi womzimba.

4. Ukukhuthaza imetabolism kunye nomjikelo wokukhupha

Inkqubo yemetabolism yeibilirubinlikhonkco eliphambili ekuhlaziyweni kwakhona kwe-hemoglobin emzimbeni. Emva kokuba i-hemoglobin ekugugeni kweeseli ezibomvu zegazi ibolile ibe yibilirubin, kufuneka idityaniswe sisibindi kwaye ikhutshwe emathunjini ngenyongo. Iibhaktheriya zamathumbu ziyayiguqula ibe yi-urobilinogen, inxalenye yayo iphinda ifakwe (i-enterohepatic circulation), kwaye intsalela ikhutshwe ngendle. Lo mjikelo awuncedi kuphela ukususa inkunkuma yemetabolism, kodwa uphinde unxibelelane nezityalo zamathumbu ukuchaphazela ibhalansi ye-metabolic jikelele.

5. Ukwenzakala kwamanqanaba angaqhelekanga

I-bilirubin egqithisileyo: Inokubangela i-jaundice (i-yellowing yesikhumba kunye ne-sclera), eqhelekileyo kwi-hepatitis, i-biliary obstruction okanye izifo ze-hemolytic. Xa i-bilirubin yasimahla iphezulu kakhulu, inokudlula kwisithintelo segazi-ingqondo kwaye ibangele i-kernicterus ye-neonatal (umonakalo wengqondo).

I-bilirubin ephantsi kakhulu: Uphononongo lwakutsha nje lufumanise ukuba ukonyuka kancinci kwi-bilirubin kunokuba nefuthe lokukhusela, ngelixa amanqanaba asezantsi kakhulu anokuthi adityaniswe nomngcipheko owongeziweyo wesifo sentliziyo kunye nesifo somzimba, kodwa indlela ethile isafuna ukufundwa.

●Yintoni Ukwandiswa kwesicelo sezonyango Bilirubin ?

1. Iimathiriyeli ezingundoqo zamayeza

I-Bilirubin iyona nxalenye ephambili ye-bezoar eyenziweyo kwaye isetyenziswe kwiziyobisi ezingaphezu kwe-130, ezifana ne-cardiovascular and cerebrovascular drug (i-85% esebenzayo ekudambiseni isifo senhliziyo) kunye namalungiselelo okulawulwa kwe-menopausal.

2. Amalungiselelo eNano (BRNPs)

Ngobuchwepheshe be-nanocarrier, ukusebenza kunye nokujoliswa kwe-bilirubin kuye kwaphuculwa kakhulu:

Isilonda esiswini esibuhlungu: i-chitosan-bilirubin (CS-BR), inqanda ukukhutshwa kwezinto ezivuthayo kunye nokukhuthaza ukuvuselelwa kwe-mucosal

Isibindi esinamafutha angenawo utywala: i-polyethylene glycol-bilirubin (PEG-BR), iyanciphisa ukuqokelelwa kwamafutha esibindi nge-30%, kwaye iyanciphisa i-triglycerides ngama-40%

Psoriasis: Hydrogelibilirubin, iphucula izilonda zesikhumba, ngaphandle kwe-systemic toxicity ye-corticosteroids

I-Stroke: I-TRPM2 channel inhibitor A23, iibhloko ze-bilirubin neurotoxicity kunye nokunciphisa ubungakanani be-infarct.

Ezinye izicelo ze-bilirubin: ukufuywa kwezilwanyana, ukukhuselwa kwendalo kunye neemveliso ezisebenzayo

I-Aquaculture: Ukongeza i-4% ye-bilirubin ukondla ngokuphindwe kabini ukuveliswa kwe-shrimp emhlophe kwaye kwandisa inzuzo yobunzima be-carp nge-155.1%;

Ukutya okusebenzayo: I-anti-glycation oral liquid, idityaniswe ne-antioxidant ye-bilirubin ukulibazisa ukuguga kwesikhumba.

●Unikezelo ENTSHA BilirubinUmgubo