I-Bifidobacterium Longum: uMgcini wamathumbu

• Yintoni iBifidobacteria Longum ?

I-Bifidobacterium longum ibisoloko ibambe indawo esembindini kuphononongo lwabantu lobudlelwane phakathi kwee-microbes kunye nempilo. Njengelona lungu lininzi kwaye lisetyenziswa ngokubanzi kwi-Bifidobacterium genus, ubungakanani bemarike yehlabathi kulindeleke ukuba budlule kwi-US $ 4.8 yebhiliyoni ngo-2025, kunye nezinga lokukhula lonyaka elihlanganisiweyo le-11.3%. Uphononongo lwango-2025 olupapashwe kwi-Nature Microbiology yaqinisekisa ukuba i-Bifidobacterium longum iyakwazi ukulawula impatho yexhala ngokusebenzisa i-axis ye-gut-brain, ebonisa ukuba le "thumbu lemveli" lilungisa ngokutsha imeko yeshishini lezempilo kwinqanaba elitsha.

I-Bifidobacterium longum: I-Gram-positive, i-non-spore-forming, kunye ne-anaerobic ngokungqongqo, ikhula ngokufanelekileyo kwi-36-38 ° C kwaye inyamezela uluhlu lwe-pH lwe-5.5-7.5. Ukuxinwa kweeseli zayo ezisebenzayo kwi-MRS inkcubeko medium inokufikelela kwi-10 ^ 10 CFU / mL.

Ukulungiswa kwemizi-mveliso: Ukusebenzisa iteknoloji ye-microencapsulation, izinga lokusinda kweeseli ezisebenzayo linyuswe ukuya kuma-92%.

• Ziziphi iiNzuzoBifidobacteria Longum?

Ngokusekwe kwizifundo ezingaphezu kwe-3,000 zehlabathi, i-Bifidobacterium longum ibonisa iziphumo ezininzi zebhayoloji:

1. Ulawulo lweMpilo yamathumbu

I-Microbiome Modulation: Icinezela i-pathogens ngokukhupha i-peptides ye-antimicrobial (efana ne-bifidocin), ukwandisa ubuninzi be-intestinal bifidobacteria ngamaxesha angama-3-5.

Ukulungiswa kwe-Mucosal: Iphakamisa ukubonakaliswa kweprotheni ye-occludin, iyanciphisa ukunyanzeliswa kwamathumbu emathunjini (i-FITC-dextran permeability yehle nge-41%), kwaye inciphisa i-leaky gut syndrome. 

2. Ulawulo lwamajoni omzimba

Ibhalansi yeCytokine:Bifidobacteria longumivuselela i-IL-10 secretion (yandisa i-concentration ngamaxesha e-2.1), inqanda i-TNF-α (iyancipha nge-58%), kwaye iphucula isifo sofuba. 

I-Allergy Intervention: Inciphisa amanqanaba e-serum IgE nge-37% kwaye inciphisa iziganeko ze-atopic dermatitis kwiintsana kunye nabantwana abancinci (OKANYE = 0.42).

3. I-Neuropsychiatric Modulation

I-Gut-Brain Axis Effects: Ivula indlela ye-vagus nerve, ukunciphisa ukunyanzeliswa kwexesha lokungashukumi kwiigundane ezinxulumene nokuxhalaba nge-53%. Ungenelelo lweMetabolic: I-SCFAs (i-short-chain fatty acids) ilawula i-GABA receptors kunye nokuphucula umgangatho wokulala kwiigundane ezibonisa uxinzelelo olungapheliyo.

4. UThintelo lweZifo kunye noNyango

I-Metabolic Syndrome: Ukunciphisa i-glucose yegazi ngokukhawuleza nge-1.8 mmol / L kwizigulane ezinesifo sikashukela sohlobo lwe-2 kunye nokuphucula i-HOMA-IR index nge-42%.

I-Adjuvant Cancer Therapy: Ukudibanisa kunye ne-5-FU kwandisa izinga lokusinda kweegundane ezithwele umhlaza wekoloni nge-31% kunye nokunciphisa umthamo we-tumor nge-54%.

• Yintoni UkusetyenziswaBifidobacteria Longum ?

IBifidobacterium longum igqobhoza imida yemveli, yenze iindawo ezintandathu eziphambili zesicelo:

1. Ishishini lokutya

Iimveliso zobisi ezivundisiweyo: Xa zidityaniswe neStreptococcus thermophilus, inyusa i-yoghurt viscosity ngamaxesha angama-2.3 kwaye yandisa ubomi beshelufu ukuya kwiintsuku ezingama-45.

Ukutya okusebenzayo: Ukongeza i-5 × 10 ^ 9 CFU / g kwimivalo ye-cereal kwandisa ukuhamba kwamathumbu ukusuka kwi-2.1 ukuya kwi-4.3 amaxesha ngeveki kubantu abanobunzima.

2. Amayeza

Amachiza angaphaya kwekhawuntara (OTC):Bifidobacteria longumiicapsules ezintathu zebhaktheriya eziphilayo (i-Lizhu Changle) zineentengiso zonyaka ezidlula iibhokisi zezigidi ezingama-230 kwaye zisebenza nge-89% ekunyangeni urhudo.

I-Biologics: Iipilisi ezingaphantsi kweelwimi ezinyibilikayo ngokukhawuleza zonyusa isantya se-probiotic colonization ngokuphindwe kathathu kwaye zifumene imvume ye-FDA eFast Track.

3. Ezolimo kunye nokutya

Imfuyo kunye nokufuya iinkukhu: Ukudibanisa i-1 × 10 ^ 8 CFU / kg yesondlo kunciphisa urhudo kumantshontsho eehagu ngama-67% kwaye kwandisa ukuguqulwa kokutya nge-15%. Ukukhuselwa kweZityalo: Ukutyala iRhizosphere kunciphise ubungwa bebhaktiriya yetumato nge 42% kwaye kwandise isivuno nge 18%.

4. Izithako zokuthambisa

Ukulungiswa komqobo: i-0.1% isicatshulwa sebhaktheriya esincitshisiweyo se-TEWL (ukulahlekelwa kwamanzi e-transepidermal) nge-38%, ukufumana isatifikethi se-EU ECOCERT.

Izicelo ezichasene nokuguga: zidibenebifidobacteria longumngeepeptides, yanciphisa ubunzulu bemibimbi ye-periorbital ngama-29%, ifumana isatifikethi sokuthambisa sokusebenzisa okukhethekileyo kwiSebe lezeMpilo laseJapan, lezaBasebenzi neNtlalontle.

5. ITekhnoloji yokuSingqongileyo

Ukucocwa kwamanzi amdaka: Ukuthotywa komgangatho we-ammonia nitrogen ngama-78% kuye kwaphunyezwa, kucuthwe ukuveliswa kodaka ngama-35%.

I-Biofuel: Ukusebenza kokuveliswa kwe-acetic acid kwanda ukuya kwi-12.3 g / L, ukunciphisa iindleko nge-40% xa kuthelekiswa neenkqubo zendabuko.

6. Impilo Yezilwanyana Zasekhaya

Ukutya kwezilwanyana ezifuywayo: Ukongeza i-2 × 10 ^ 8 CFU / kg ekudleni kwezinja kuphuculwe amanqaku e-fecal nge-61% kunye nokunciphisa urhudo.

Ukuguqulwa kwendlela yokuziphatha: Isitshizi sathomalalisa ixhala lokwahlukana kwaye sanciphisa isimilo esindlongondlongo ngama-54%.

• UBonelelo oluPhezulu lweNewgreenBifidobacteria LongumUmgubo