Isicatshulwa seAndrographis Paniculata: Isithako seHerbal esinamandla sokulwa neebhaktiriya kunye ne-Anti-ukudumba.

●Yintoni i Andrographis Paniculata Extract?

IAndrographis paniculata, ekwaziwa ngokuba "ulonwabo lwexesha elinye" kunye "nengca ekrakra", sisityalo sonyaka se-Acanthaceae. Ivela eMzantsi Asia njengeIndiya kunye neSri Lanka, kwaye ngoku isasazwe ngokubanzi kwiindawo ezifumileyo nezishushu ezifana neGuangdong kunye neFujian eChina. Isityalo sonke sithanda ukukrakra kakhulu, kunye nesiqu esikwere, amaqabunga achaseneyo, kunye nexesha leentyantyambo zika-Agasti-Septemba. Iyeza lemveli laseTshayina lisebenzisa iziphumo zalo zokucoca ubushushu kunye nokukhupha, ukupholisa igazi kunye nokunciphisa ukudumba ukunyanga imikhuhlane, umkhuhlane, isifo segazi, izilonda kunye nokulunywa yinyoka. Ishishini lanamhlanje likhupha izithako ezisebenzayo ukusuka kwiziqu kunye namagqabi ngokusebenzisa i-supercritical CO₂ extraction kunye ne-bio-enzymatic hydrolysis iteknoloji ukwenza umgubo oqhelekileyo kunye nomxholo we-andrographolide we-8% -98%, ukukhuthaza ukuphuculwa kwawo kumayeza esintu ukuya kwimathiriyeli ekrwada yamazwe ngamazwe.

Izithako ezingundoqo ezisebenzayo zeAndrographis Paniculata Eiixtractszikhompawundi diterpenoid lactone, accounting 2% -5%24, ingakumbi kuquka:

1.  Andrographolide:i-molecular formula C₂₀H₃₀O₅, i-accounting ye-30% -50%, iyona nto isebenzayo kwi-antibacterial and anti-inflammatory.
2.  I-Dehydroandrographolide:i-molecular formula C₂₀H₂₈O₄, indawo yokunyibilikisa i-204℃, kunye nomsebenzi obalulekileyo wokuchasana ne-tumor.
3. 14-Deoxyandrographolide:ifomula yemolekyuli C₂₀H₃₀O₄, kunye nokusebenza okubalaseleyo ngokuchasene ne-leptospirosis.
4. Neoandrographolide:ifomula yemolekyuli C₂₆H₄₀O₈, ukunyibilika kakuhle kwamanzi, ezifanelekileyo kumalungiselelo omlomo.

Ukongezelela, i-flavonoids, i-phenolic acids kunye ne-oyile eguquguqukayo yamacandelo e-synergistically iphakamisa imisebenzi ye-antioxidant kunye ne-immunomodulatory.

●Ziziphi iiNzuzo ze Andrographis Paniculata Extract?

1. Immunomodulation kunye ne-Anti-Infection

I-Antibacterial kunye ne-antiviral: I-Andrographolide inezinga lokuthintela elingaphezu kwe-90% kwi-Staphylococcus aureus kunye ne-Shigella dysenteriae, kunye nokusebenza kwayo kwezonyango ekunyangeni i-bacillary dysentery kuthelekiswa ne-chloramphenicol. Isicatshulwa sayo samanzi sinokunciphisa iziganeko zomkhuhlane nge-30% kwaye sinciphise ixesha lokubanda nge-50%.

Immunoenhancement: Ngokuvula i-macrophages kunye ne-T lymphocytes, inokunyusa izinga le-CD4⁺ lymphocytes kwizigulane ze-HIV (idatha yekliniki: 405→ 501 / mm³, p=0.002).

2. I-Anti-Tumor kunye ne-Angiogenesis Inhibition

I-anti-tumor ethe ngqo: I-Dehydroandrographolide inokuthintela ukukhula kwe-W256 i-tumor etshintshwe kwaye inqande ukwanda kweeseli zomhlaza ngendlela exhomekeke kwidosi.

I-Anti-angiogenesis: I-Andrographolide ivimba i-tumor angiogenesis ngokunciphisa ukubonakaliswa kwe-VEGFR2 kunye nokuvimbela indlela ye-ERK / p38 yokubonisa, kunye ne-IC₅₀ ye-100-200μM.

3. I-Metabolism kunye nokuKhuselwa kwamalungu

Ukukhuselwa kwesibindi kunye nokunciphisa i-lipid: I-Andrographolide igcina amanqanaba e-glutathione kwaye iyanciphisa i-malondialdehyde (MDA) kwi-carbon tetrachloride imodeli yokulimala kwesibindi nge-40%, engcono kune-silymarin.

Ukukhuselwa kwe-cardiovascular: Ilawula i-nitric oxide / ibhalansi ye-endothelin, ilibazisa i-atherosclerosis, kwaye iyanciphisa amanqanaba e-lipid yegazi kwimivundla yokulinga.

4. I-Anti-Inflammatory kunye ne-Antioxidant

I-extract yamanzi ye-stem inamandla amakhulu okukhupha i-radicals yamahhala (IC₅₀ = 4.42μg / mL), ephindwe ngamaxesha angama-4 ngaphezu kwe-antioxidants yokwenziwa kwaye ifanelekile kwizifo ezingapheliyo ezivuthayo.

●Zithini Izicelo ZeAndrographis Paniculata Extract ?

1. Amayeza kunye noNyango lweKlinikhi

Amachiza okulwa nezifo: asetyenziselwa isifo segazi sebhaktiriya, inaliti yenyumoniya kunye namalungiselelo omlomo we-pharyngitis, kunye neqondo lokunyanga kwekliniki elingaphezu kwama-85%.

Amachiza ajoliswe kwi-Anti-tumor: I-Andrographolide derivative "Andrographine" ingene kwiSigaba sesi-II solingo lwezonyango lwe-leukemia kunye namathumba aqinileyo.

Ukulawulwa kwezifo ezingapheliyo: unyango lwe-adjuvant ye-retinopathy yesifo sikashukela (i-0.5-2mg / kg / ngosuku) kunye ne-rheumatoid arthritis (1-3mg / kg / ngosuku).

2. Ukufuywa kwezilwanyana kunye nokuzalisa okuluhlaza

Enye indlela yokubulala iintsholongwane: Icompound Andrographis paniculata feed additives inciphisa izinga lorhudo lwamantshontsho eehagu kwaye yonyusa izinga lokuphila kweebroiler; ukongeza i-4% isicatshulwa kwi-carp feed, izinga lokuzuza ubunzima lifikelela kwi-155.1%, kwaye izinga lokuguqulwa kwesondlo liphuculwe kwi-1.11.

Uthintelo nolawulo lwezifo: Inaliti ye-Andrographis paniculata inyanga inyumoniya yehagu kunye ne-enteritis, ngeqondo lokunyanga le-90% kunye nezinga lokufa eliyi-10%.

3. Ukutya kweMpilo kunye neeMichiza zemihla ngemihla

Ukutya okusebenzayo: Andrographis paniculataisicatshulwaii-capsules (i-200mg ngosuku) ziqaliswe kwiimarike zaseYurophu naseMelika zokulawulwa kwe-immune kunye nokukhusela okubandayo.

Iimveliso zokhathalelo lwesikhumba: Yongeza kwi-anti-inflammatory essences kunye ne-sunscreens ukukhulula umonakalo we-UV kunye nokubomvu kwesikhumba esibucayi.

4. Iimpumelelo kwiMimandla asakhulayo

Iziyobisi ezichasene ne-angiogenic: Ukuphuhliswa kwamalungiselelo ajoliswe kuyo kwi-tumor kunye ne-diabetes retinopathy iye yaba yindlela ephambili ye-biology yokwenziwa.

Ukhathalelo lwempilo yezilwanyana ezifuywayo: I-Anti-inflammatory and immunomodulatory supplements for dogs and cats yaqaliswa kwimarike yaseMntla Melika, ngezinga lokukhula lonyaka lama-35%.

●Unikezelo ENTSHAAndrographis Paniculata ExtractUmgubo