● Ke engβ-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) ke coenzyme ea bohlokoa e teng liseleng tsohle tse phelang, e nang le mokhoa oa molek'hule oa C₂₁H₂₇N₇O₁₄P₂, le boima ba molek'hule ba 663.43. E le mohloli oa mantlha oa karabelo ea redox, mahloriso a eona a supa ka kotloloho ts'ebetso ea metabolism ea matla a cellular mme e tsejoa e le "chelete ea matla a cellular".
Litšobotsi tsa kabo ea tlhaho:
Phapang ea lisele: Likahare tsa lisele tsa myocardial ke tse phahameng ka ho fetisisa (hoo e ka bang 0.3-0.5 mM), e lateloa ke sebete, 'me e tlaase ka ho fetisisa letlalong (e fokotseha ka 50% lilemo tse ling le tse ling tse 20 ka lilemo);
Sebopeho sa ho ba teng: ho kenyelletsa foromo e nang le oxidized (NAD⁺) le foromo e fokotsehileng (NADH), le tekanyo e matla ea karolelano pakeng tsa tse peli e bonahatsa boemo ba metabolism ea cellular.
● Tšireletso ea mahlaseli aβ-NAD.
Eketsa sekhahla sa ho phela ha lisele tsa "hematopoietic stem" ka mor'a ho pepesetsoa mahlaseli ka makhetlo a 3, 'me u fumane tlhokomelo ea bohlokoa ho tsoa morerong oa NASA oa bophelo bo botle ba sebaka.
Mohloli oa boitokiso: Ho tloha ho nts'etsopele ea baeloji ho ea phetohong ea maiketsetso ea baeloji
1. Mokhoa oa setso oa ho ntša
Lisebelisoa tse tala: lisele tsa tomoso (litaba 0.1% -0.3%), sebete sa phoofolo;
Ts'ebetso: ho sithabela ha ultrasonic → ion exchange chromatography → ho omisa ka leqhoa,β-NADbohloeki ≥ 95%.
2. Enzyme catalytic synthesis (mokhoa o tloaelehileng)
Substrate: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Molemo: Theknoloji ea enzyme e sa sebetseng e ka eketsa chai ea β-NAD ho isa ho 97%.
3. Synthetic biology (tataiso ea bokamoso)
Escherichia coli e hlophisitsoeng ka liphatsa tsa lefutso:Mofuta o entsoeng ka boenjiniere o entsoeng ke ChromaDex, USA, o nang le tlhahiso ea ho belisoa ea 6 g/L;
Setso sa sele ea limela: Motso oa koae o nang le boea o hlokomela tlhahiso e kholo ea NAD precursor NR.
● Melemo ea hoβ-NAD?
1. Anti-botsofali core mochine
Kenya tshebetsong Sirtuins:Eketsa ts'ebetso ea SIRT1/3 ka makhetlo a 3-5, lokisa tšenyo ea DNA, le ho lelefatsa bophelo ba tomoso ka 31%;
Matlafatso ea Mitochondrial:Liphuputso tsa meriana li bontša hore batho ba lilemo li 50-70 ba tlatsetsa 500 mg NMN letsatsi le leng le le leng, 'me tlhahiso ea mesifa ea ATP e eketseha ka 25% ka mor'a libeke tsa 6.
2. Tšireletso ea methapo
Lefu la Alzheimer:Ho khutlisetsa maemo a neuronal NAD⁺ ho ka fokotsa deposition ea β-amyloid, mme ts'ebetso ea kelello ea mefuta ea litoeba e ntlafala ka 40%;
Lefu la Parkinson: β-NADSireletsa dopaminergic neurons ka ho thibela PARP1.
3. Ho kenella ha lefu la metabolism
Lefu la tsoekere:Ntlafatsa kutloisiso ea insulin, liteko tsa litoeba tse nonneng li bonts'a phokotso ea 30% ea tsoekere ea mali;
Tšireletso ea pelo:Ntlafatsa ts'ebetso ea endothelial, 'me u fokotse sebaka sa li-atherosclerotic plaque ka 50%.
● Likopo Tsaβ-NAD?
1. Lekala la bongaka
Lithethefatsi tse khahlanong le botsofali: Litokisetso tse ngata tsa NMN li tiisitsoe e le lithethefatsi tsa likhutsana ke FDA bakeng sa myopathy ea mitochondrial;
Mafu a Neurodegenerative: NAD⁺ ente ea methapo e kene litekong tsa bongaka tsa Phase II (lipontšo tsa lefu la Alzheimer).
2. Lijo tse sebetsang
Li-supplement tsa molomo: β-NADjoalo ka ha li-capsules tsa NAD precursor (NR/NMN) li na le thekiso ea selemo le selemo e fetang $500 milione.
Phepo ea lipapali:Ntlafatsa mamello ea baatlelete, 'me ho na le lisebelisoa tse ling tsa NAD' marakeng ho ntlafatsa ts'ebetso ea lipapali.
3. Litlolo tse ncha
Mokotla oa ho thibela botsofali:0.1% -1% NAD⁺ e rarahaneng, e lekiloeng ho fokotsa botebo ba wrinkles ka 37%;
Tlhokomelo ea letlalo la hlooho:Kenya tšebetsong lisele tsa stem tsa follicle ea moriri, 'me u kenye lisebelisoa tsa NAD ho shampoo e khahlanong le tahlehelo ea moriri.
4. Temo le lipatlisiso tsa mahlale
Bophelo ba liphoofolo:Ho eketsa li-precursors tsa NAD ho jala fepa ho eketsa palo ea malinyane ka 15%;
Ho lemoha ka baeloji:Karo-karolelano ea NAD/NADH e sebelisoa e le letšoao la boemo ba metabolism ea lisele bakeng sa tlhahlobo ea pele ea mofetše.
●NEWGREEN Phepeloβ-NADPhofo
Nako ea poso: Jun-17-2025
