●Ke Eng? Ivermectin?
Ivermectin ke semi-synthetic macrolide lithibela-mafu tse nkiloeng ho belisoa le tlhoekiso ea Streptomyces avermitilis. Haholo-holo e na le likarolo tse peli: B1a (≥80%) le B1b (≤20%). Mokhoa oa eona oa molek'hule ke C48H74O14, boima ba molek'hule ke 875.09, 'me nomoro ea CAS ke 70288-86-7.
Ka 2015, ba sibolotseng William C. Campbell le Satoshi Omura ba ile ba hapa Khau ea Nobel ea Physiology kapa Medicine bakeng sa tlatsetso ea bona ea katleho ntoeng khahlanong le bofofu ba noka le elephantiasis.
Lintho tsa 'mele le tsa lik'hemik'hale
Thepa: phofo ea kristale e tšoeu kapa e bobebe, e sa nkheng;
Ho qhibiliha: ho qhibiliha habonolo ka har'a metsoako ea lintho tse phelang tse kang methanol, ethanol, acetone, 'me hoo e batlang e sa qhibilihe ka metsing (solubility e ka bang 4μg/mL);
Botsitso: ha ho bonolo ho senyeha ka mocheso oa kamore, empa ho bonolo ho senya leseling, ho hlokahala ho bolokoa sebakeng se tiisitsoeng le se nang le leseli, 'me polokelo ea nako e telele e hloka sebaka se tlaase sa mocheso oa 2-8 ℃;
●Ke Eng SeoMelemoEa Ivermectin ?
Ivermectin e hlasela tsamaiso ea methapo ea likokoana-hloko hantle ka litsela tse peli:
1. E khothalletsa ho lokolloa ha neurotransmitter ea inhibitory γ-aminobutyric acid (GABA) ho thibela phetiso ea matšoao a methapo;
2. E bula likanale tsa ion tsa glutamate-gated chloride ho susumetsa hyperpolarization le ho holofala ha mesifa ea likokoana-hloko.
Bokhoni ba eona ba ho bolaea li-nematodes (joaloka liboko le li-hookworms) le li-arthropods (joaloka mites, liboseleise le linta) li holimo ho 94% -100%, empa ha e sebetse khahlanong le liboko le li-flukes.
●Ke Eng SeoKopoOf Ivermectin?
1. Sebaka sa bongaka ba liphoofolo (phapang e nepahetseng ea litekanyetso)
Likhomo / linku: 0.2mg / kg (ente ea subcutaneous kapa tsamaiso ea molomo), e ka felisa li-nematode tsa mala, filaria ea matšoafo le likhoele holim'a 'mele;
Likolobe: 0.3mg/kg (ente ea intramuscular), sekhahla sa taolo ea liboko le likhoele ke hoo e ka bang 100%;
Lintja le likatse: 6-12μg/kg ho thibela le ho phekola liboko, 200μg/kg ho bolaea likokoanyana tsa tsebe;
Khoho: 200-300μg/kg (tsamaiso ea molomo) e sebetsa hantle khahlanong le liboko tsa likhoho le likokoanyana tsa lengole.
2. Kalafo ea batho
Ivermectinke moriana oa mantlha oa Mokhatlo oa Lefatše oa Bophelo, o sebelisetsoang haholo:
Onchocerciasis (bofofu ba noka): 0.15-0.2mg/kg tekanyo e le 'ngoe, sekhahla sa ho hlaka ha microfilariae se feta 90%;
Stregostrongyloidiasis: 0.2mg / kg tekanyo e le 'ngoe;
Tšoaetso ea Ascaris le whipworm: 0.05-0.4mg / kg kalafo ea nako e khutšoanyane.
3. Likokoana-hloko tsa temo
Jwalo ka sebolayaditsheneketsi sa bio-source, se sebediswa ho laola mite ya dimela, ditshwele tsa diamondback, basebetsi ba merafong ya mahlaku, jwalojwalo, mme e na le matshwao a masala a tlase.
●Polokeho le Mathata
Ivermectine batla e bolokehile bakeng sa liphoofolo tse anyesang (ho thata ho kenella mokoallong oa mali le boko), empa ho ntse ho na le li-contraindication:
Tšusumetso e mpe: Ka linako tse ling hlooho e opang, lekhopho, keketseho ea nakoana ea li-enzyme tsa sebete, le litekanyetso tse phahameng li ka baka ataxia;
Mefuta e fapaneng ea kutloisiso ea mefuta: Lintja tsa balisa le mefuta e meng ea lintja li ka ba le neurotoxicity e matla;
Chefo ea ho ba le bana: Liteko tsa liphoofolo li bontša hore litekanyo tse phahameng li na le kotsi ea teratogenicity (cleft palate, claw deformity).
Bothata ba lefats'e ba ho hanyetsa likokoana-hloko bo ntse bo mpefala le ho feta. Phuputso ea 2024 e bontšitse hore motsoako oa ivermectin le albendazole o ka ntlafatsa katleho khahlanong le filariasis. Lik'hamphani tse ngata tsa meriana lefatšeng ka bophara li khothalletsa ntlafatso ea theknoloji ea lithethefatsi tse tala, 'me bohloeki bo fihlile ho 99%.
● NEWGREEN Supply High QualityIvermectinPhofo
Nako ea poso: Jul-18-2025
