Epimedium(Horny Goat Weed) Extract- Icariin e ba Tšepo e Ncha ea ho Loantša Kankere ea Urothelial

Urothelial carcinoma ke e 'ngoe ea mefuta e atileng haholo ea mofets'e, 'me ho hlaha ha hlahala le metastasis e le lisosa tse kholo tsa bokamoso. Ka 2023, ho hakanngoa hore linyeoe tse 168,560 tsa mofets'e oa moroto li tla fumanoa United States, 'me ho shoele batho ba ka bang 32,590; hoo e ka bang 50% ea linyeoe tsena ke urothelial carcinoma. Ho sa tsotellehe ho fumaneha ha mekhoa e mecha ea phekolo, e kang chemotherapy e thehiloeng platinum le PD1 antibody-based immunotherapy, bakuli ba fetang halofo ea urothelial carcinoma ba ntse ba sa arabele liphekolo tsena. Ka hona, ho na le tlhokahalo e potlakileng ea ho batlisisa mahlahana a macha a phekolo ho ntlafatsa boemo ba bakuli ba urothelial carcinoma.

Icariin(ICA), motsoako o ka sehloohong o sebetsang ho Epimedium, ke moriana oa setso oa Machaena oa tonic, aphrodisiac le anti-rheumatic. Hang ha e nkiloe, ICA e kenngoa ka metabolized ho icartin (ICT), e fanang ka liphello tsa eona. ICA e na le mesebetsi e mengata ea likokoana-hloko, ho kenyelletsa le ho laola ho itšireletsa mafung, ho ba le thepa ea antioxidant, le ho thibela tsoelo-pele ea hlahala. Ka 2022, li-capsules tsa Icaritin tse nang le ICT e le motsoako o ka sehloohong li ile tsa amoheloa ke Tsamaiso ea Sechaba ea Lihlahisoa tsa Bongaka ea Chaena (NMPA) bakeng sa phekolo ea pele ea kankere e tsoetseng pele e sa sebetseng ea hepatocellular carcinoma. Ho feta moo, e bontšitse katleho e kholo ea ho lelefatsa bophelo ka kakaretso ba bakuli ba nang le kankere e tsoetseng pele ea hepatocellular carcinoma. ICT ha e bolaee feela lihlahala ka ho toba ka ho etsa hore apoptosis le autophagy, empa hape e laola tumor immune microenvironment mme e khothalletsa karabelo ea 'mele ea ho itšireletsa mafung e khahlanong le hlahala. Leha ho le joalo, mokhoa o tobileng oo ICT e laolang TME ka oona, haholo-holo ka urothelial carcinoma, ha e utloisisoe ka botlalo.

Haufinyane tjena, bafuputsi ba Lefapha la Urology, Sepetlele sa Huashan, Univesithi ea Fudan e hatisitse sehlooho se reng "Icaritin e thibela tsoelo-pele ea mofetše oa urothelial ka ho hatella PADI2-mediated neutrophil infiltration le neutrophil extracellular trap formation" koranteng ea Acta Pharm Sin B. Phuputso e senotse horeicariine fokolitse haholo ho ata ha hlahala le tsoelo-pele ha e ntse e thibela ho kenella ha neutrophil le NET synthesis, e bontšang hore ICT e ka 'na ea e-ba NETs inhibitor e ncha le phekolo e ncha ea urothelial carcinoma.

Ho khutla ha hlahala le metastasis ke tsona lisosa tse kholo tsa lefu ho urothelial carcinoma. Ka har'a tumor microenvironment, limolek'hule tse laolang hampe le lisele tse ngata tsa 'mele tsa ho itšireletsa mafung li hatella ho itšireletsa mafung. The inflammatory microenvironment, e amanang le neutrophils le neutrophil extracellular traps (NETs), e khothalletsa metastasis ea hlahala. Leha ho le joalo, hajoale ha ho na lithethefatsi tse thibelang ka ho khetheha li-neutrophils le NETs.

Phuputsong ena, bafuputsi ba bontšitse ka lekhetlo la pele seoicariin, phekolo ea pele bakeng sa kankere e tsoetseng pele le e sa phekoleheng ea hepatocellular carcinoma, e ka fokotsa li-NET tse bakoang ke ho ipolaea NETosis le ho thibela ho kenella ha neutrophil ka har'a tumor microenvironment. Ka mekhoa, ICT e tlama le ho thibela polelo ea PADI2 ho li-neutrophils, kahoo e thibela PADI2-mediated histone citrullination. Ho phaella moo, ICT e thibela tlhahiso ea ROS, e thibela tsela ea pontšo ea MAPK, 'me e hatella metastasis ea tumor e bakoang ke NET.

Ka nako e ts'oanang, ICT e thibela tumor PADI2-mediated histone citrullination, kahoo e thibela ho ngoloa ha liphatsa tsa lefutso tsa neutrophil tse kang GM-CSF le IL-6. Ka lehlakoreng le leng, ho theoleloa ha polelo ea IL-6 ho theha letoto la maikutlo a taolo ka JAK2/STAT3/IL-6 axis. Ka phuputso ea morao-rao ea lisampole tsa kliniki, bafuputsi ba fumane khokahano lipakeng tsa li-neutrophils, NETs, ​​prognosis ea UCa le phonyoha ea 'mele ea ho itšireletsa mafung. ICT e kopantsoeng le immune checkpoint inhibitors e ka ba le phello ea synergistic.

Ka kakaretso, thuto ena e fumane horeicariinhaholo fokotsa hlahala ho ata le tsoelo-pele ha a ntse a inhibiting neutrophil infiltration le NET synthesis, le neutrophils le NETs phetha karolo inhibitory ka hlahala immune microenvironment ea bakuli ba urothelial carcinoma. Ho feta moo, ICT e kopantsoeng le anti-PD1 immunotherapy e na le phello ea synergistic, e fana ka maikutlo a leano la phekolo bakeng sa bakuli ba urothelial carcinoma.