● Ke Eng?Sclareol ?
Sclareol, lebitso la lik'hemik'hale (1R,2R,8aS) -decahydro-1-(3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, foromo ea molek'hule C₂₀H₃₆O₂, boima ba molek'hule 308.35-10-309-CAS. Ke motsoako oa bicyclic diterpenoid, o nang le ponahalo ea phofo e tšoeu ea crystalline, ntlha e qhibilihisang 95-105 ℃, ntlha e belang 398.3 ℃, e sa qhibiliheng ka metsing, 'me e qhibiliha habonolo ka har'a metsoako ea tlhaho. Tšobotsi ea eona ea mantlha ke hore e na le monko o tšoarellang nako e telele o ts'oanang le oa ambergris, e nang le monko o monate le monko o matla, e leng se etsang hore e be sehlahisoa se loketseng bakeng sa litlolo tsa boleng bo holimo.
Mohloli oa tlhaho ke haholo-holo inflorescence le lithupa le makhasi a semela sa Lamiaceae sa Salvia Sclarea L., se lengoang ka bongata libakeng tse phahameng tse lithaba tse kang leboea la Shaanxi le Honghe, Yunnan, Chaena. Ka lebaka la phapang e kholo ea mocheso pakeng tsa motšehare le bosiu le mongobo o loketseng, clarysol libakeng tsena tse hlahisang lihlahisoa e na le bohloeki bo phahameng le monko o hloekileng.
Ho na le mekhoa e 'maloa ea mantlha ea ho kopanya sclareol:
1. Tšebeliso ea lik'hemik'hale
Ka kakaretso,sclareolntsa e sebelisoa e le thepa e tala bakeng sa ho ntša le tlhoekiso. Masala a sclareol ka mor'a ho ntšoa ha oli e qhibiliha ka ethanol, 'me sclareol e kenngoa ka mokhoa oa linale tse tšoeu ka mor'a hore ho be le serame se tlaase sa mocheso, ho sefa, phekolo ea carbon activated, dilution le mehato e meng. Ka mor'a ho felloa ke metsi ka centrifugal, ho omisoa ha vacuum, ho senya le ho hlahloba, sclareol e nang le joala e ngata e ka fumanoa.
2. Biosynthesis
Kaho ea feme ea sele ea tomoso ea brewer: Thutong, li-synthases tse peli tsa TPS le LPPs ka sage li ile tsa kopanngoa pele ho mofuta oa tomoso, e leng se ileng sa eketsa tlhahiso easclareol. Joale N-terminus ea TPS-LPPS e ne e amana le karolo ea protheine e tlamang ea maltose ho tsoela pele ho ntlafatsa botsitso ba enzyme le ho eketsa chai hape. Joale, sehlopha sa lipatlisiso se ile sa arola tsela eohle ea metabolic ka li-module tse tharo: tsela e bohareng ea metabolic bakeng sa ho fana ka acetyl coenzyme A, tsela ea isoprenoid biosynthesis le module ea taolo ea phetoho ea sistimi. Ka ho khutlisa le ho hlakoloa ha liphatsa tsa lefutso tse amanang, mofuta oa chassis o ka fanang ka acetyl-CoA le NADPH hantle o ile oa hahuoa, mme tlhahiso ea sclareol e ile ea ntlafatsoa le ho feta ka ho hlahisa mefuta e meng ea lefutso. Qetellong, phello ea module e 'ngoe le e' ngoe ka ho qaptjoa ha sclareol e ile ea hlahlojoa ka mokhoa oa metabolic oa khatello e entsoeng, 'me ho ile ha fumanoa hore li-module tse tharo li na le phello ea synergistic. Ho belisoa ha Fed-batch ho ne ho etsoa ka li-shake flasks le bioreactors, 'me qetellong sclareol e ile ea etsoa hantle ho Saccharomyces cerevisiae ho sebelisoa tsoekere e le thepa e tala, ka lihlahisoa tsa 11.4 g/L.
●Ke Eng SeoMelemoEa Sclareol ?
Lithuto tsa morao-rao li senotse ts'ebetso ea bioloji e fapaneng ea sclareol, haholoholo lefapheng la mafu a tsamaiso ea methapo e bohareng:
1. Anti-inflammatory le neuroprotective:
E thibela ts'ebetso e feteletseng ea microglia, e fokotsa maemo a ho ruruha TNF-α le IL-1β, e imolla mathata a ho sisinyeha ho litoeba tsa mohlala oa Parkinson, le ho sireletsa dopamine neurons;
Ntlafatsa ts'ebetso ea kelello mefuteng ea lefu la Alzheimer's. Tekanyetso ea 50-200mg/(kg·d) e ka thibela tšebetso ea li-astrocyte bokong le ho fokotsa ho beoa ha protheine ea β-amyloid.
2. Ts'ebetso ea anticancer:
E na le cytotoxicity e matla ho mela ea lisele tsa mofetše joalo ka mouse leukemia (P-388) le human epidermal carcinoma (KB), mme e thibela ho ata ha hlahala ka ho etsa hore apoptosis e be teng.
3. Antibacterial le antioxidant:
E na le mokhoa o pharaletseng oa ho thibela ho hōla ha baktheria, 'me katleho ea eona ea antioxidant e makhetlo a 50 ea vithamine E, e loketseng ho roala maqeba le lihlahisoa tsa tlhokomelo ea letlalo tse thibelang botsofali.
●Ke Eng SeoKopoOf Sclareol ?
1. Indasteri ea tatso le monko o monate:
E le eona ntho e ka sehloohong e sebelisoang ha ho etsoa ambergris, e nkela sebaka sa tlhaho sa maruarua a kotsing ea ho timela. Chelete e nyenyane e sebelisoa ka ho toba litlolo tse nkhang hamonate tse phahameng ho fana ka monko o monate le o tsitsitseng.
2. Lipatlisiso le nts'etsopele ea meriana:
Lithethefatsi tsa lefu la Alzheimer's / Parkinson: li-capsules tsa molomo kapa liente li kene lipatlisisong tsa pele, tse lebisang thibelo ea neuroinflammation;
Anti-cancer adjuvant therapy: e kopantsoeng le meriana ea chemotherapy ho matlafatsa ho bolaoa ha lisele tsa tumor.
3. Litlolo le lijo:
Lihlahisoa tsa tlhokomelo ea letlalo tse khahlanong le botsofali: eketsa 0.5% -2% ho thibela photoaging le ho fokotsa ultraviolet erythema;
Li-preservatives tsa tlhaho: tse sebelisoang lijong tse mafura ho lelefatsa bophelo ba sethala, 'me li bolokehile ho feta lihlahisoa tsa maiketsetso tsa lik'hemik'hale.
●NEWGREEN Supply High QualitySclareolPhofo
Nako ea poso: Jun-25-2025
