● Ke engChenodeoxycholic acid ?
Chenodeoxycholic Acid (CDCA) ke e 'ngoe ea likarolo tse ka sehloohong tsa vertebrate bile, e ikarabellang bakeng sa 30% -40% ea acid bile ea motho, 'me litaba tsa eona li batla li le holimo ka har'a nyolo ea likhantsi, matata, likolobe le liphoofolo tse ling.
Liphello tsa theknoloji ea sejoale-joale ea ho hula:
Supercritical CO₂ extraction: ho ntšoa tlas'a mocheso o tlase le maemo a khatello e phahameng ho qoba masala a organic solvent, 'me bohloeki bo ka fihla ho feta 98%;
Mokhoa oa ho belisoa ha likokoana-hloko: ho sebelisa mefuta e entsoeng ka liphatsa tsa lefutso (e kang Escherichia coli) ho kopanya CDCA, litšenyehelo li fokotsehile ka 40%, e lumellanang le mokhoa oa tlhahiso ea meriana e tala;
Mokhoa oa ho kopanya lik'hemik'hale: ho sebelisa k'holeseterole e le selelekela, e fumanoa ka karabelo ea mehato e mengata, e loketseng lihlahisoa tse phahameng tsa boleng ba meriana.
Lintho tsa 'mele le tsa lik'hemik'hale tsaChenodeoxycholic acid :
Lebitso la lik'hemik'hale: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Foromo ea molek'hule: C₂₄H₄₀O₄
Boima ba molek'hule: 392.58 g/mol
Ponahalo: phofo e tšoeu ea kristale
Solubility: e qhibiliha hanyenyane ka metsing, e qhibiliha habonolo ka ethanol, ether, chloroform
Sebaka se qhibilihang: 165-168 ℃
Botsitso: e tsotella khanya le mocheso, e hloka ho beoa sehatsetsing hole le leseli (2-8 ℃)
● Melemo ea hoChenodeoxycholic acid ?
1. Ho Qhala Hoa K'holeseterole Gallstones
Mokhoa: thibela ho fokotsa HMG-CoA ho sebete, ho fokotsa motsoako oa k'holeseterole, ho khothalletsa secretion ea bile acid, 'me butle-butle ho qhala li-gallstones tsa k'holeseterole;
Lintlha tsa bongaka: 750mg CDCA ka letsatsi bakeng sa likhoeli tse 12-24, sekhahla sa ho qhibiliha ha gallstone se ka fihla ho 40% -70%.
2. Kalafo ea Primary Biliary Cholangitis (Pbc)
Lithethefatsi tsa pele: FDA e amohetse Chenodeoxycholic Acid CDCA bakeng sa PBC, e ntlafatsa matšoao a sebete (ALT / AST e fokotsehile ho feta 50%);
Phekolo ea motsoako: e kopantsoengChenodeoxycholic acidka ursodeoxycholic acid (UDCA), katleho e ntlafatsoa ka 30%.
3. Taolo ea Mafu a Metabolic
Ho theola lipids tsa mali: ho theola serum kakaretso ea k'holeseterole (TC) le low-density lipoprotein (LDL);
Anti-diabetes: ho ntlafatsa kutloisiso ea insulin, liteko tsa liphoofolo li bonts'a hore tsoekere ea mali e theoha ka 20%
4. Anti-Inflammatory And Immune Regulation
Thibela tsela ea NF-κB le ho fokotsa ho lokolloa ha mabaka a ho ruruha (TNF-α, IL-6);
Liteko tsa meriana li bontšitse hore tekanyo ea ntlafatso ea sebete sa sebete ho bakuli ba nang le lefu la sebete le se nang joala (NAFLD) le feta 60%.
● Likopo TsaChenodeoxycholic acid ?
1. Lekala la Bongaka
Kalafo ea Gallstone: Matlapa a CDCA (250mg / tablet), tekanyo ea letsatsi le letsatsi 10-15mg / kg;
Phekolo ea PBC: litokisetso tsa motsoako le UDCA (joaloka Ursofalk®), thekiso ea selemo le selemo ea lefatše e feta US $ 500 milione;
Lipatlisiso tse khahlanong le hlahala: ho thibela ho ata ha lisele tsa kankere ea sebete ka ho laola li-receptor tsa FXR, ho kena litekong tsa kliniki tsa Phase II.
2. Lijo tse Sebetsang le Lihlahisoa tsa Bophelo
Matlapa a tšireletso ea sebete: motsoako oa motsoako (CDCA + silymarin), o fokotsa tšenyo ea sebete sa joala;
Li-capsules tse theolang lipid: li kopantsoe le tomoso e khubelu e ntšitsoeng ho laola metabolism ea lipid ea mali.
3. Ho Rua Liphoofolo Le Tlhapi ea Metsing
Li-additives tsa fepa: ntlafatsa metabolism ea mafura a liphoofolo le likhoho, fokotsa sekhahla sa mafura ka mpeng;
Bophelo ba litlhapi: ho eketsa 0.1%chenodeoxycholic acidho matlafatsa khanyetso ea lefu la carp le ho eketsa sekhahla sa ho phela ka 15%.
4. Litlolo le Tlhokomelo ea Motho
Essence e khahlanong le ho ruruha: 0.5% -1% ho phaella, ho ntlafatsa kutlo ea letlalo le letlalo;
Tlhokomelo ea letlalo la hlooho: thibela Malassezia le ho fokotsa tlhahiso ea dandruff.
Ho tloha ka mokhoa o tloaelehileng oa ho ntša bile ho ea ho motsoako oa likokoana-hloko, chenodeoxycholic acid e ntse e fetoha ho tloha "motsoako oa tlhaho" ho ea "meriana e nepahetseng". Ka ho teba ha lipatlisiso mabapi le mafu a metabolic le anti-tumor, CDCA e kanna ea fetoha sesebelisoa sa mantlha sa kalafo ea lefu la sebete, lijo tse sebetsang le lintho tse phelang, tse lebisang leqhubu le lecha la indasteri ea bophelo bo botle ea 100 bilione.
● NEWGREEN SupplyChenodeoxycholic acidPhofo
Nako ea poso: Jun-11-2025
