Synephrine Hydrochloride: "Arrinta Kobcinta Cadaadiska Dhiigga Dabiiciga ah" ee laga soosaaray Citrus Aurantium

●Waa maxay Synephrine Hydrochloride?

Synephrine HCl waa qaabka hydrochloride ee synephrine, oo leh caanaha kiimikada C₉H₁₃NO₂ · HCl (miisaanka kelli 203.67). Hordhaceeda dabiiciga ah ee synephrine waxay inta badan ka soo baxdaa miraha yaryar ee la qalajiyey (citrus aurantium) ee warshadda Rutaceae. Citrus aurantium waxaa si ballaaran loogu qaybiyaa gobollada Wabiga Yangtze ee Shiinaha, sida Sichuan, Jiangxi, iyo Zhejiang. Maadada synephrine ee ku jirta miraha yaryar waxay gaari kartaa ilaa 30% miisaanka qalalan. Soo saarista dhaqameedku waxay ku tiirsan tahay soo saarista khamriga (75% soo saarista ethanol reflux 3 jeer, dhalid ≥ 85%), laakiin sannadihii ugu dambeeyay, hal-abuurka tignoolajiyada ayaa diiradda saaray cagaar iyo waxtar sare:

Enzymatic hydrolysis-membrane separation: pectinase ka kooban hydrolyzes pectin at 40 ° C iyo pH 4.5, oo ay weheliso 0.22μm xuubka dhoobada inorganic sifaynta, heerka ka saarista wasakhdu waxay gaartaa 91%, iyo nadiifinta ayaa kordhay in ka badan 95%;

Tignoolajiyada beddelka fangas: Akadeemiyada Shiinaha ee Sayniska Beeraha ayaa soo saartay habka halsano ee Ganoderma lucidum si loo soo saaro walxaha synephrine u eg, hoos u dhigista kharashka 30% iyo yaraynta cadaadiska macdanta sharci darrada ah ee kheyraadka duurjoogta ah.

●Maxay YihiinFaa'iidooyinkaee Synephrine Hydrochloride ?

Synephrine hydrochloride, sida dual agonist of adrenaline α/β reseptors, dib u qaabaynta qiimaha kiliinikada iyada oo loo marayo saamaynta bartilmaameedyo badan:

1. Gurmadka Wadnaha

Reseptors α xiiso leh si ay u xakameeyaan xididdada dhiigga iyo kordhinta cadaadiska dhiigga, kaas oo loo isticmaalo suuxinta, hypotension, samatabbixinta naxdinta leh, iyo xawaaraha bilawga 40% ka dhaqso badan daawooyinka dhaqameed;

Dhaqdhaqaaqa β reseptors si kor loogu qaado qandho myocardial iyo hagaajinta shaqada bamgareynta bukaanada qaba wadne-gabka.

2. Farogelinta Nidaamka Neefsashada

Synephrinehydrochloridekaraa ssi xoog leh u kala furfura muruqa siman ee bronki, gabi ahaanba ka soo horjeeda spasm histamine-ku keeno, oo waxay kordhisaa FEV1 index shaqada sambabada ee bukaanka qaba neefta bronki 25%.

3. Xeerka dheef-shiid kiimikaadka

Kacaanka oksaydhka dufanka: Kicin heerka dheef-shiid kiimikaad ee nudaha adipose brown 50%, iyo qaadashada maalinlaha ah ee 20 mg waxay yarayn kartaa heerka dufanka jidhka 3.5%;

Awoodda ilaalinta neerfayaasha: Dib-u-soo-celinta acetylcholinesterase, waxay hagaajinaysaa dhibcaha shaqada garashada ee bukaannada waallida 30%, iyo muddada ficilku waa laba jeer ka badan daawooyinka caadiga ah.

Helitaanka xudduudaha: Daraasad 2020 ay samaysay Jaamacadda Koonfur-galbeed ayaa markii ugu horreysay daaha ka qaaday shaqada ilaalinta miraha iyo khudradda - 0.1mmol/Lsynephrine hydrochloridedaaweyntu waxay joojin kartaa dhaqdhaqaaqa polyphenol oxidase ee diirka litchi, dib u dhigista browning iyadoo nidaaminaysa dheef-shiid kiimikaadka xuubka, iyo kordhinta nolosha shelf ilaa 14 maalmood.

●Maxay YihiinCodsigaOf Synephrine Hydrochloride?

1. Suuqa ugu Sarreeya ee Goobta Dawooyinka

Diyaarinta gargaarka degdegga ah: cirbadaha iyo kaniiniyada waxaa loo isticmaalaa hypotension qalliinka iyo shoogga.

Maareynta cudurrada daba-dheeraada: marka lagu daro aminophylline si loo daweeyo neefta bronki, heerka weerarka degdega ah ayaa la dhimay 60%.

Daawooyinka miisaanka luminta: sida beddelka dabiiciga ah ee ephedrine, waxaa loo isticmaali karaa kabka ciyaaraha.

2. Hal-abuurka Ilaalinta Beeraha

Lychee browning inhibitor: ka dib markii lychee la gooyay oo lagu daaweeyaasynephrine hydrochloride, wadarta qiimaha waa kaliya 1/3 ee silsiladda qabow ee dhaqameed.

Dahaarka citrus-ka-ciribtirka: nanoemulsion oo lagu daray chitosan, heerka bakteeriyada bakteeriyada waa> 99%, iyo xilliga kaydinta heerkulka qolka waxaa lagu kordhiyey 21 maalmood.

3. Kordhinta Alaabooyinka Macaamilka ee shaqaynaya

Cabbitaannada tamarta: "Synephrine + taurine" cabitaannada shaqeynaya waxay hagaajin karaan dulqaadka isboortiga

Cunnada caafimaadka neerfaha: diyaarinta kaabsal ee lagu beegsanayo acetylcholinesterase si loo hagaajiyo xusuusta daciifka ah ee waayeelka.

● Qalab Cusub oo Cagaaran Tayo Sare leh Synephrine Hydrochloride Budada