Glutathione: Antioxidant Awood leh

●Waa maxayGlutathione ?

Glutathione (GSH) waa isku-dhafka tripeptide (qaabka molecular C₁₀H₁₇N₃O₆S) waxaa sameeyay glutamic acid, cysteine;iyo glycine ku xiranγ-amide bonds. Xuddunta firfircoon waa kooxda sulfhydryl (-SH) ee cysteine, taas oo siinaya awood yareyn xooggan.

Laba nooc oo nafsiyeed oo waaweyn oo glutathione ah:

1. glutathione la dhimay (GSH): waxay ka dhigan tahay in ka badan 90% wadarta guud ee jidhka waana qaabka ugu muhiimsan ee shaqada antioxidant iyo sun-saarista; waxay si toos ah uga saartaa xagjirka xorta ah waxayna unugyada ka ilaalisaa waxyeelada oksaydh-qaadka.

2. Oxidized glutathione (GSSG): oo ay samaysay oksaydhka laba molecules ee GSH (GSSG), oo leh dhaqdhaqaaq jireed oo daciif ah; hoos u dhigista glutathione reductase, waxay kuxirantahay NADPH in lagu dhimo GSH si loo ilaaliyo dheelitirka redox-ka gacanta.

●Waa maxay faa'iidooyinka TheGlutathione ?

1. Hawlaha Jirka ee Muhiimka ah

Sun-saarista iyo ilaalinta beerka:

Glutathione cKala saar biraha culus (lead, meerkuri), sunta daroogada (sida cisplatin) iyo dheef-shiid kiimikaadka khamriga. Cirbadda xididka ee 1800mg / maalintii waxay si weyn u wanaajin kartaa shaqada beerka, iyo heerka wax ku oolka ah ee daaweynta cudurka beerka khamriga ayaa ka sarreeya 85%.

Kaaliyaha ka hortagga burada:

Glutathione waxay noqon kartaa rwaxay kicisaa kemotherapy nephrotoxicity, kordhiso waxqabadka unugyada dabiiciga ah ee dilaaga ah (unugyada NK) 2 jeer, iyo in la joojiyo diiqada unugyada burooyinka.

Ilaalinta neerfaha iyo indhaha:

Glutathione karaa rka takhalusi calaamadaha hore ee cudurka Parkinson oo ay yareeyaan dopamine neurotoxicity; Codsiga maxaliga ah ee dhibcaha indhaha waxay hagaajin karaan boogaha lafaha iyo waxay joojin karaan horumarinta cataracts.

2. Codsiyada Caafimaadka iyo Quruxda

Nidaaminta difaaca ka-hortagga gabowga: Hawl-geli borotiinka Sirtuins oo dib u dhig soo gaabinta telomere; kor u qaadida shaqada lymphocyte iyo in la yareeyo sii deynta arrimaha bararka;

Cadaadiska iyo ka saarista dhibcaha: Jooji dhaqdhaqaaqa tyrosinase waxayna yareysaa wax soo saarka melanin. Si caafimaad ahaan loo caddeeyey si loo hagaajiyo barti maqaarka iyo in la yareeyo qoto dheer laalaabkii 40%.

●Waa maxay Codsigasee Glutathione ?

1. Goobta Caafimaadka

Duritaan: loo isticmaalo ilaalinta kiimoterabiga (1.5g/m² qiyaasta), gargaarka degdega ah ee sumowga ah, oo u baahan in lagu kaydiyo meel ka fog iftiinka;

Diyaarinta afka: isticmaalka muddada dheer (200-500mg/wakhti, ka badan 6 bilood) si loo kordhiyo kaydka GSH ee jirka iyo caawinta daaweynta cudurrada beerka ee joogtada ah.

2. Cunto shaqaynaysa

Kaabayaasha Antioxidant: Vitamin C-ga isku jira (500mg fitamiin C maalintii waxay kordhin kartaa heerarka GSH 47%) ama selenium si kor loogu qaado difaaca;

Hangover iyo cuntada ilaalinta beerka: lagu darayglutathionecabbitaannada waxtarka leh si loo dardargeliyo dheef-shiid kiimikaadka khamriga loona yareeyo dhaawaca beerka.

3. Hal-abuurnimada qurxinta

Nuxurka caddaynta: si weyn loogu isticmaalo suuqa Aasiya si loo joojiyo melanin, oo ay weheliso tignoolajiyada microneedle si loo hagaajiyo dhexgalka maqaarka;

Nafaqada ka hortagga gabowga: Liposome oo ku dahaaran GSH waxay u adkaysataa waxyeelada ultraviolet waxayna yaraynaysaa sawir-qaadista erythema 31%-46%.

4. Codsiga Teknolojiyadda Soo Koraysa

Gaadhida daawada la beegsaday: nanogels-ka jawaab celinta GSH waxay si xakamaysan u sii dayn kartaa dawooyinka kiimoterabiga (sida doxorubicin) goobta burada, hagaajinta waxtarka iyo yaraynta waxyeelada;

Ilaalinta deegaanka iyo beeraha: Samee agab noole-guuri kara oo sahamin waxyaabaha lagu daro quudinta si kor loogu qaado difaaca xoolaha iyo digaaga.

Laga soo bilaabo patent-ka soo saarista khamiirka ilaa wax-soo-saarka tirada badan ee kumanaan tan oo bayoolajiga synthetic maanta, habka warshadaha ee glutathione ayaa xaqiijiyay isbeddelka "ilaaliyaha unugga" ee "mashiinka farsamada". Mustaqbalka, iyada oo la dhamaystirayo xaqiijinta kiliinikada ee calaamadaha cusub ee ilaalinta neuroprotection iyo ka-hortagga gabowga, molecule-ka-nolol-qaadashada ee antioxidant-ka ayaa sii wadi doonta bixinta dhiirigelinta sayniska ee caafimaadka aadanaha iyo cimri dhererka. 

●Sahayda CUSUBGlutathione Budada