Chitosan: Faa'iidooyinka, Codsiyada iyo in ka badan

Waa maxay Chitosan?

Chitosan(CS) waa polysaccharide dabiiciga ah ee labaad ee ugu weyn, inta badan laga soo saaro qolofyada qolofleyda sida shrimp iyo carsaanyo. Maaddada aasaasiga ah ee chitin waxay xisaabisaa ilaa 27% qashinka ka-hortagga shrimp iyo carsaanyada, iyo wax-soo-saarka sannadlaha ah ee caalamiga ah ayaa ka sarreeya 13 milyan oo tan. Soo saarista dhaqameedku waxay u baahan tahay saddex hab: decalcification leaching acid (kala diri calcium carbonate), karkaraya alkaline si ay u saarto borotiinka, iyo 40-50% deacetylation alkali xoogga saaray, iyo ugu dambeyntii helo adag cad oo leh heerka deacetylation ka badan 70%.

Horumarka sanadihii ugu dambeeyay waa horumarinta chitosan fangas: chitosan laga soo saaro fangaska sida Ganoderma lucidum habka enzymatic wuxuu leeyahay darajo deacetylation ka badan 85%, miisaan kelli ah oo kaliya 1/3 oo ka mid ah shrimp iyo carsaanyo (qiyaastii 8-66kDa), oo aan ku jirin borotiinnada xasaasiyadda ayaa si weyn u wanaajiyay. Kooxda Akademiyada Shiinaha ee Sayniska Beeraha ayaa xaqiijiyay in habka soo saarista fungus-chitosan hybrid ay xakameyn karto weecanka miisaanka kelli gudaha ± 5%, xallinta dhibaatada isbedbedelka xilliyeedka ee alaabta ceeriin ee badda.

Waa maxay faa'iidooyinkaChitosan ?

Loolanka asaasiga ah ee chitosan wuxuu ka yimaadaa amino iyo kooxaha hydroxyl ee bilaashka ah ee silsiladeeda molecular, samaynta "sanduuqa molecular" gaar ah:

Jawaabta Caqliga leh:Amino protonation waxay u ogolaataa chitosan inay ku milmo jawi acidic ah, gaarista sii deynta pH-koontaroolka (sida waxtarka sii deynta doxorubicin dawada ka hortagga kansarka ee pH 5.0 ee buro microenvironment waa 7.3 jeer ka mid ah deegaanka jir ahaaneed);

Ku-dhejinta Nafleyda:Kharashka togan wuxuu isku daraa kharashka taban ee xuubka xuubka si uu u dheereeyo wakhtiga haynta daawada ee godka afka iyo mareenka caloosha iyo mindhicirka, iyo adhesion xuubka ayaa kordhay 3 jeer ka dib markii wax laga beddelo thiolation;

Isku-dhafka deegaanka:Chitosan waxaa si buuxda hoos ugu dhigi kara lysozyme (munad-dareen-celinta sare waxay luminaysaa 78% miisaanka 72 saacadood), iyo alaabooyinka nabaad-guurku waxay ka qaybqaataan wareegga carrada iyo nitrogen.

Farsamaynta Ka-hortagga Bakteeriyada Gaar ahaan waa mid caan ah:Chitosan miisaan yar oo miisaankeedu yar yahay waxay burburisaa daacadnimada xuubka bakteeriyada, iyo dhexroorka aagga xannibaadda ee Escherichia coli iyo Staphylococcus aureus waa 13.5mm; Awooddeeda antioxidant waxay sidoo kale baabi'in kartaa oksijiinta fal-celiska ah ee ay soo saarto walaaca sunta cayayaanka, iyadoo yaraynaysa maadada malondialdehyde ee isbinaajka lagu daweeyay chlorpyrifos 40%.

Waa maxay CodsigaChitosan?

1. Biomedicine: Laga bilaabo Sutures ilaa Ilaalada Tallaalka Mrna

Nidaamka gaarsiinta caqliga leh: Waxtarka gudbinta ee CS/pDNA nanocomplex waa amarrada 2 ee ka sarreeya kan liposomes, oo noqda mid cusub oo jecel sidayaal hidde-sideyaasha aan fayraska ahayn;

Dayactirka dhaawaca: Ganoderma lucidum chitosan-glucan jel ka kooban waxay soo gaabinaysaa wakhtiga xinjirowga 50%, iyo qaab-dhismeedka dalool ee saddex-geesoodka ah wuxuu dardargeliyaa dib-u-soo-nooleynta unugyada granulation;

Xasiloonida tallaalka: Wakiilka difaaca ee la qaboojiyey ee Chitosan wuxuu ka dhigayaa haynta dhaqdhaqaaqa tallaalka mRNA in ka badan 90% heerkulka qolka, xallinta dhibaatada gaadiidka silsiladda qabow.

2. Beeraha Cagaaran: Furaha Deegaanka ee Yaraynta Isticmaalka Bacriminta

ChitosanBacriminta-dahaarka leh ee sii-deynta ah (CRFs) waxay kordhisaa waxtarka iyada oo loo marayo habab saddex jibaaran:

Siideynta la bartilmaameedsaday: Graphene oxide/chitosan nanofilms waxay si joogto ah u sii daayaan nitrogen muddo 60 maalmood ah ciidda acidic ah, iyo heerka isticmaalka ayaa 40% ka sarreeya kan sulfur-dahaarka leh;

Iska caabbinta dalagyada: Ku kicinta dhirta si ay u abuuraan chitinase, dhalidda yaanyada ayaa kordhay 22%, iyada oo la dhimayo heerka wax soo saarka O₂⁻;

Horumarinta carrada: Kordhi walxaha organic 1.8 jeer, balaadhi bulshooyinka actinomycete 3 jeer, oo gabi ahaanba hoos u dhac 60 maalmood gudahooda iyada oo aan la hadhin.

3. Baakadaha Cuntada: Kacaanka Ilaalinta ee Filimada Isku-dhafka ah ee borotiinka cayayaanka

Kooxda hal-abuurka ee Akademiyada Cilmiga Beeraha ee Shiinaha oo la isku daraychitosanoo leh borotiinka mealworm iyo soosaarida ethanol propolis ee raran:

Qalabka farsamada: xoogga xajinta ayaa kordhay 200%, iyo xannibaadaha uumiga biyaha ayaa gaaray 90% filimada ku saleysan batroolka;

Dhaqdhaqaaqa bakteeriyada: heerka bakteeriyada bakteeriyada kharriba strawberry ayaa dhaaftay 99%, nolosha shelf ayaa la kordhiyay ilaa 14 maalmood, heerka biodegradation heerka wuxuu ahaa 100%.

4. Daabacaadda Dharka iyo Midabaynta: Xalka Dabiiciga ah ee Polyester-ka Antistatic

Iyada oo loo marayo daawaynta dhimista alkali, godadka iyo kooxaha karboksylka ayaa laga sameeyay dusha polyesterka. Ka dib markii chitosan ay ku xiran tahay tartaric acid:

Antistatic joogto ah: iska caabbinta ayaa laga dhimay 10¹²Ω ilaa 10⁴Ω, iyo soo celinta qoyaanku waxay ahaanaysaa 6.56% kadib 30 dhaqid;

Xayeysinta birta culus: Cu²⁰ waxtarka chelation ee daabacaadda iyo dheehidda biyaha wasakhda ah waa>90%, qiimuhuna waa 1/3 xabagta synthetic.

•Cusub Cusbooneysii Tayo SareChitosanBudada