Waa maxayChenodeoxycholic acid ?
Chenodeoxycholic Acid (CDCA) waa mid ka mid ah qaybaha ugu muhiimsan ee xaniinyaha laf dhabarta, oo lagu qiyaaso 30% -40% xashida bile bini'aadamka, iyo waxa ku jira ayaa aad ugu sarreeya xaniinyaha berriga, shinbiraha, doofaarka iyo xayawaanka kale.
Horumarrada tignoolajiyada soo saarista casriga ah:
Soo saarista sare ee CO₂: soo saarista heerkulka hooseeya iyo xaaladaha cadaadiska sare si looga fogaado haraaga dareeraha organic, iyo daahirnimadu waxay gaari kartaa in ka badan 98%;
Habka halsano ee microbial: iyadoo la isticmaalayo nuucyada hiddo-wadaha (sida Escherichia coli) si loo soo saaro CDCA, qiimaha waxaa la dhimay 40%, taas oo la socota isbeddelka wax soo saarka daawada cagaaran;
Habka isku dhafka kiimikada: iyadoo la isticmaalayo kolestaroolka horudhac ahaan, waxaa lagu helaa falcelin-tilaabo badan, oo ku habboon alaabada heerka dawada ee nadiifka ah.
sifooyinka jirka iyo kiimikaad eeChenodeoxycholic acid :
Magaca kiimikada: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Qaaciddada molecular: C₂₄H₄₀O₄
Miisaanka unugyada: 392.58 g/mol
Muuqaalka: budada crystalline cad
Solubility: in yar oo biyo ku milmay, si fudud ugu milmi kara ethanol, ether, chloroform
Meesha dhalaalka: 165-168 ℃
Xasilooni: waxay u nugul tahay iftiinka iyo kulaylka, waxay u baahan tahay in la qaboojiyo meel ka fog iftiinka (2-8 ℃)
● Maxay yihiin faa'iidooyinka ku jiraChenodeoxycholic acid ?
1. Kala dirida Dhagxaanta Xameetida ee Kolestaroolka
Mechanism: waxay xakameysaa beerka HMG-CoA reductase, waxay yareysaa isku-dhafka kolestaroolka, waxay kor u qaaddaa dheecaanka bile acid, oo si tartiib tartiib ah u milmaan dhagaxyada kolesteroolka;
Xogta bukaan-socodka: 750mg CDCA maalintiiba 12-24 bilood, heerka milanka dhagaxa xameetidu wuxuu gaari karaa 40%-70%.
2. Daawaynta Biliary Cholangitis (Pbc)
Dawooyinka safka hore: FDA waxay ogolaatay Chenodeoxycholic Acid CDCA ee PBC, waxay hagaajisaa tilmaamayaasha shaqada beerka (ALT/AST oo hoos loo dhigay in ka badan 50%);
Daaweynta isku dhafka ah: isku dhafanChenodeoxycholic acidoo leh ursodeoxycholic acid (UDCA), waxtarka ayaa la hagaajiyay 30%.
3. Nidaaminta Cudurrada dheef-shiid kiimikaadka
Hoos u dhigidda dufannada dhiigga: hoos u dhigista serum wadarta kolestaroolka (TC) iyo lipoprotein-cufnaanta hoose (LDL);
Ka hortagga sokorowga: hagaajinta dareenka insulinta, tijaabooyinka xayawaanku waxay muujinayaan in sonkorta dhiigu ay hoos u dhacdo 20%
4. Nidaaminta ka hortagga caabuqa iyo difaaca jirka
Jooji jidka NF-κB oo yareeya sii-deynta arrimaha caabuqa (TNF-α, IL-6);
Tijaabooyin caafimaad ayaa muujiyay in heerka hagaajinta beerka fibrosis ee bukaanka qaba cudurka beerka dufanka leh ee aan khamriga ahayn (NAFLD) uu ka sarreeyo 60%.
● Maxay yihiin CodsiyadaChenodeoxycholic acid ?
1. Goobta Caafimaadka
Daawaynta dhagaxa xameetida: kiniinnada CDCA (250mg/kiniin), qiyaasta maalinlaha ah 10-15mg/kg;
Daaweynta PBC: diyaarinta isku dhafan ee UDCA (sida Ursofalk®), iibka sannadlaha ah ee caalamiga ah ayaa ka badan US $ 500 milyan;
Cilmi-baarista ka-hortagga burooyinka: xakameynaya kororka unugyada kansarka beerka iyadoo la xakameynayo soo-dhoweynta FXR, gelitaanka tijaabooyinka bukaan-socodka ee Wajiga II.
2. Cuntooyinka Shaqada iyo Alaabaha Caafimaadka
Kiniiniyada ilaalinta beerka: caanaha isku dhafan (CDCA + silymarin), yaraynta dhaawaca beerka khamriga;
Kaabsoosha dufan-hooseeya: isku-dhafan leh oo laga soosaaray bariiska khamiirka cas si loo habeeyo dheef-shiid kiimikaad ee dhiigga.
3. Xanaanada Xoolaha iyo Aquaculture
Quudinta waxyaabaha lagu daro: hagaajinta dheef-shiid kiimikaadka dufanka xoolaha iyo digaaga, waxay yareeyaan heerka baruurta caloosha;
Caafimaadka kalluunka: ku daray 0.1%chenodeoxycholic acidsi kor loogu qaado iska caabinta cudurka carp iyo kordhinta heerka badbaadada 15%.
4. Waxyaalaha la isku qurxiyo iyo daryeelka gaarka ah
Nuxurka ka-hortagga bararka: 0.5% -1% kordhinta, hagaajinta finanka iyo dareenka maqaarka;
Xannaanada madaxa: waxay joojisaa Malassezia oo waxay yaraysaa soo saaridda hargabka.
Laga soo bilaabo soo saarista bile-dhaqameedka ilaa isku-dhafka microbial, chenodeoxycholic acid waxa uu ka beddelayaa "walaxda dabiiciga ah" una beddelo "daawa saxda ah". Iyadoo qoto dheer oo cilmi baaris ah oo ku saabsan cudurrada dheef-shiid kiimikaadka iyo buro-ka-hortagga, CDCA waxay noqon kartaa alaabta ceeriin ee asaasiga ah ee daaweynta cudurka beerka, cuntooyinka shaqeynaya iyo biomaterials, taasoo horseedaysa mowjad cusub oo ah 100 bilyan warshadaha caafimaadka.
● Sahayda CUSUBChenodeoxycholic acidBudada
Waqtiga boostada: Jun-11-2025
