●Waa maxay Caffeic acid?
Caffeic acid, magaca kiimikaad 3,4-dihydroxycinnamic acid ( formula kelli C₉H₈O₄, CAS No. 331-39-5), waa iskudar phenolic acid dabiiciga ah oo si ballaaran looga helo dhirta. Waa crystal jaalaha ah muuqaal ahaan, wax yar ku milmay biyo qabow, si fudud u milmi biyo kulul, ethanol iyo ethyl acetate, oo leh barta dhalaalaysa ee 194-213 ℃ (habsocodyo kala duwan ayaa kala duwan), orange-cas ee xalalka alkaline, iyo cagaar madow oo xiriir la leh chloride ferric.
Ilaha soo saarista asaasiga ah waxaa ka mid ah:
●Dhirta daawada:Asteraceae Solidago, qorfe, løvetann (oo ka kooban caffeic acid ≥ 0.02%), Ranunculaceae Cimicifuga rhizome;
●Khayraadka khudaarta iyo miraha:diirka liinta, blueberry, tufaax, brokoli iyo khudaarta cruciferous;
●Waxyaabaha cabitaanka:digirta qaxwaha (oo ah qaabka chlorogenic acid esters), khamri (oo lagu daray tartaric acid).
Tiknoolajiyada casriga ahi waxay isticmaashaa soo saarista CO₂ supercritical ama tignoolajiyada bio-enzymatic hydrolysis si ay uga nadiifiso aashitada caffeic ee alaabta ceeriin ee dhirta, iyadoo nadiif ah in ka badan 98%, oo buuxinaysa heerarka heerka dawooyinka iyo qurxinta.
Waa maxay faa'iidooyinka Caffeic acid?
Caffeic acid waxay soo bandhigtaa hawlo badan oo bayooloji ah sababtoo ah qaabdhismeedkeeda o-diphenolic hydroxyl:
1. Antioxidant iyo Anti-Bararka:
Waxay leedahay awoodda ugu xooggan ee xagjirnimada bilaashka ah ee ka dhexjirta cinnamic acid hydrogenated, waxtarkeeduna waa 4 jeer ka badan fitamiin E. Waxay xannibtaa falcelinta silsiladda peroxidation ee lipid iyadoo samaynaysa qaabdhismeedka quinone;
Waxay joojisaa isku-darka leukotriene (waxay nidaamisaa difaaca iyo caabuqa), waxay yaraynaysaa dhaawaca UV ee maqaarka maqaarka, waxayna yaraynaysaa index erythema 50%.
2. Ilaalinta dheef-shiid kiimikaadka iyo xididdada dhiigga:
Caffeic acidWaxay joojisaa oksaydhka lipoprotein-cufnaanta hoose (LDL) waxayna yaraynaysaa samaynta huurada atherosclerotic;
Tijaabooyin cunto dufan badan leh, ururinta dufanka visceral ayaa hoos u dhacay 30% iyo triglycerides beerka ayaa hoos u dhacay 40%.
3. Ilaalinta Neerfaha iyo Ka-hortagga Burada:
Calaamadaha insulinta ee hippocampal oo la xoojiyay, hagaajinta shaqada xusuusta ee moodooyinka cudurka Alzheimers, iyo hoos u dhigidda borotiinka β-amyloid;
Waxay joojisaa faafitaanka unugyada kansarka fibrosarcoma waxayna joojisaa korriinka burada iyadoo la dhimayo methylation DNA.
4. Kordhinta Hemostasis iyo Leukocyte:
Waxay hoos u dhigtaa microvessels waxayna wanaajisaa shaqada arrimaha xinjirowga. Waxa loo isticmaalaa kiliinikada qalliinka hemostasis iyo leukopenia kemotherapy ka dib, oo leh heer wax ku ool ah oo ka badan 85%.
● Maxay yihiin Codsiyada Caffeic acid ?
Isticmaalka caffeic acid wuxuu daboolayaa beero badan:
1. Daawo:kiniiniyada caffeic acid (hemostasis, korodhka unugyada dhiiga cad), dawooyinka lidka ku ah buro ee bartilmaameedka ah (tijaabada caafimaad ee wajiga succinic acid II)
2. Waxyaabaha la isku qurxiyo:muraayad qorraxdu (zinc oxide synergistic si ay u kordhiso qiimaha SPF), nuxurka caddaynta (xakamaysa tyrosinase, heerka xannibaadda melanin 80%)
3. Warshadaha cuntada:ilaalinta dabiiciga ah (dib u dhigista oxidation kalluunka), cabitaannada shaqada (anti-oxidation iyo anti-bararka), isticmaalka isku-dhafka ah ee ascorbic acid
4. Beeraha iyo Ilaalinta Deegaanka:sunta cayayaanka deegaanka ah (waxay joojisaa suufka bollworm protease), wax ka beddelka dhogorta ( guryaha antioxidant ayaa kordhay 75%)
●Xeerarka Isticmaalka iyo BadbaadadaeeCaffeic acid
Qiyaasta daawada:Kiniinnada Caffeic acid: 0.1-0.3g hal mar, 3 jeer maalintii, 14 maalmood sida koorsada daaweynta, tirada platelet waxay u baahan tahay in la kormeero (la yareeyo marka> 100 × 10⁹ / L, u baahan tahay inaad la tashato dhakhtar ka hor isticmaalka);
Contraindications:Kahortagga haweenka uurka leh iyo bukaanka qaba xaalad dhiig-xinjirow ah; loo isticmaalo si taxadar leh bukaanada qaba cillad beerka iyo boogaha caloosha.
Waxyaabaha lagu qurxiyo:0.5% -2% ayaa lagu daray alaabada la caddeeyo, horay loogu milmay ethanol ka dibna lagu daray matrix aqueous si looga fogaado qallafsanaanta.
Shuruudaha kaydinta:lagu shaabadeeyey meel mugdi ah, qaboojiyaha 2-8℃, shaqaynaysa 2 sano (diyaarinta dareeraha ayaa loo baahan yahay in laga ilaaliyo oksaydhka iyo hoos u dhaca)
●Sahayda CUSUBCaffeic acidBudada
Waqtiga boostada: Jul-23-2025
