Soosaarista Andrographis Paniculata: Ka-hortagga Bakteeriyada Awoodda leh iyo Walxaha Dhirta-Bararka

●Waa maxay Andrographis Paniculata Extract?

Andrographis paniculata, oo sidoo kale loo yaqaan "farxad hal mar ah" iyo "caws qadhaadh", waa geedo dhireed sanadle ah oo ka tirsan qoyska Acanthaceae. Waxa uu asal ahaan ka soo jeedaa Koonfurta Aasiya sida Hindiya iyo Sri Lanka, waxaana hadda si weyn loogu qaybiyaa qoyaanka iyo meelaha kulul sida Guangdong iyo Fujian ee Shiinaha. Geedka oo dhan wuxuu dhadhamiyaa qadhaadh, oo leh jirid labajibbaaran, caleemo iska soo horjeeda, iyo muddada ubax ee Agoosto-Sebtembar. Daawo dhaqameed Shiinees ah waxay isticmaashaa saamaynta ay ku leedahay nadiifinta kulaylka iyo sunta, qaboojinta dhiiga iyo yaraynta bararka si ay u daweyso hargab, qandho, shuban, boogaha iyo qaniinyada masaska. Warshadaha casriga ahi waxay ka soo saaraan maaddooyinka firfircoon ee afkoda iyo caleemaha iyada oo loo marayo soo saarista CO₂ supercritical iyo tignoolajiyada bio-enzymatic hydrolysis si ay u sameeyaan budo heersare ah oo leh maaddo andrographolide ah oo ah 8% -98%, korna u qaadaysa ka cusboonaysiinta daawada dhirta dadweynaha ilaa alaabta ceeriin ee caalamiga ah.

Waxyaabaha asaasiga ah ee firfircoon eeAndrographis Paniculata Esoosaaridwaa xeryahooda lactone diterpenoid, oo xisaabiya 2%-5%24, inta badan ay ku jiraan:

1.  Andrographolide:formula molecular C₂₀H₃₀O₅, oo lagu qiyaaso 30% -50%, waa walaxda ugu muhiimsan ee firfircoon ee bakteeriyada iyo ka hortagga bararka.
2.  Dehydroandrographolide:caanaha molecular C₂₀H₂₈O₄, barta dhalaalka 204℃, oo leh hawlo muhiim ah oo ka hortagga burada.
3. 14-Deoxyandrographolide:caanaha molecular C₂₀H₃₀O, oo leh waxtar sare oo ka dhanka ah leptospirosis.
4. Neoandrographolide:caanaha molecular C₂₆H₄₀O, biyo wanaagsan oo milmay, ku haboon diyaarinta afka.

Intaa waxaa dheer, flavonoids, acids phenolic iyo qaybaha saliidda kacsan waxay si wada jir ah u xoojiyaan shaqada antioxidant iyo immunomodulatory.

●Waa maxay Faa'iidooyinka Andrographis Paniculata Extract?

1. Immunomodulation and Anti-Infection

Ka-hortagga bakteeriyada iyo fayraska: Andrographolide waxay leedahay xad ka-hortag ah in ka badan 90% Staphylococcus aureus iyo Shigella dysenteriae, iyo waxtarkeeda caafimaad ee lagu daweynayo dysentery bacillary waxay la mid tahay chloramphenicol. Biyaha laga soo saaro waxay hoos u dhigi karaan dhacdooyinka hargabka 30% waxayna soo gaabin karaan koorsada hargabka 50%.

Immunoenhancement: Marka la dhaqaajiyo macrophages iyo T lymphocytes, waxay kordhin kartaa heerka CD4⁺ lymphocytes ee bukaannada HIV (xogta caafimaad: 405→501/mm³, p=0.002).

2. Ka-hortagga Burada iyo Angiogenesis

Burada tooska ah ee lidka ku ah: Dehydroandrographolide waxay joojin kartaa koritaanka burooyinka la tallaalay ee W256 waxayna joojin kartaa kororka unugyada kansarka qaab ku-tiirsanaan ah.

Anti-angiogenesis: Andrographolide wuxuu xannibaa buro angiogenesis-ka iyadoo hoos u dhigaysa muujinta VEGFR2 oo joojisay dariiqa calaamadaynta ERK/p38, oo leh IC₅₀ 100-200μM.

3. Dheef-shiid kiimikaad iyo Ilaalinta xubnaha

Ilaalinta beerka iyo dhimista dufanka: Andrographolide waxay ilaalisaa heerarka glutathione waxayna yaraynaysaa malondialdehyde (MDA) ee qaabka dhaawaca beerka ee tetrachloride kaarboon 40%, taas oo ka fiican silymarin.

Ilaalinta wadnaha iyo xididada: Waxay xakameysaa dheellitirka nitric oxide/endothelin, waxay daahisaa atherosclerosis, waxayna yaraynaysaa heerarka dufanka dhiigga ee bakaylaha tijaabada ah.

4. Anti-Bararka Iyo Antioxidant

Soosaarka biyaha ee jirida ayaa leh awooda ugu xoogan si ay uga takhalusto xagjirnimada xorta ah (IC₅₀=4.42μg/mL), taas oo 4 jeer ka waxtar badan antioxidants-ka synthetic waxayna ku habboon tahay cudurrada bararka dabadheeraad ah.

●Waa maxay CodsiyadaAndrographis Paniculata Extract ?

1. Daawaynta Iyo Daawaynta

Daawooyinka kahortaga caabuqa: loo isticmaalo shubanka bakteeriyada, cirbadeynta oofwareenka iyo diyaarinta afka ee pharyngitis, oo leh heerka daawaynta kiliinikada ee ka badan 85%.

Daawooyinka lidka-tumor-ka ah ee lala beegsaday: Andrographolide derivative “Andrographine” waxa uu galay tijaabada caafimaad ee Wajiga II ee leukemia iyo burooyinka adag.

Maareynta cudurrada daba-dheeraada: daawaynta adjuvant ee cudurka kaadi-macaanka (0.5-2mg/kg/maalintii) iyo rheumatoid arthritis-ka (1-3mg/kg/maalintii).

2. Xannaanada Xoolaha Iyo Dhaqashada Cagaaran

Antibiyootiga kale: Isku-dhafka Andrographis paniculata feed additives waxay yareeyaan heerka shubanka ee doofaarka waxayna kordhiyaan heerka badbaadada broilers; ku darista 4% soosaarida kaarp-ka, heerka korodhka miisaanku wuxuu gaaraa 155.1%, iyo heerka beddelka quudinta waxaa lagu hagaajiyay 1.11.

Kahortagga iyo xakameynta cudurrada: cirbadeynta Andrographis paniculata waxay daaweysaa oof wareenka doofaarka iyo enteritis-ka, iyada oo heerka daawadu tahay 90% iyo heerka dhimashada 10%.

3. Caafimaadka Cuntada iyo Kiimikada Maalinlaha ah

Cunto shaqaynaysa: Andrographis paniculatasoosaaridkaabsoosha (200mg maalintii) ayaa laga bilaabay suuqyada Yurub iyo Ameerika si loo xakameeyo difaaca iyo ka hortagga qabowga.

Alaabooyinka daryeelka maqaarka: Ku dar nuxurka ka hortagga bararka iyo muraayadaha qorraxda si loo yareeyo dhaawaca UV iyo casaan maqaarka xasaasiga ah.

4. Horumarka Beeraha Soo Koraya

Dawooyinka lidka ku ah angiogenic: Kobcinta diyaargarowga la beegsanayo ee burooyinka iyo retinopathy-ka sonkorowga ayaa noqday jihada muhiimka ah ee bayoolajiga synthetic.

Daryeelka caafimaadka xayawaanka: Ka hortagga bararka iyo dheellitirka difaaca jirka ee eeyaha iyo bisadaha ayaa laga bilaabay suuqa Waqooyiga Ameerika, iyada oo heerka kobaca sanadlaha ah 35%.

●Sahayda CUSUBAndrographis Paniculata ExtractBudada