Waa maxayβ-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) waa koenzyme fure ah oo ku jira dhammaan unugyada noolaha, oo leh qaacido kelli ah oo ah C₂₁H₂₇N₇O₁₄P₂, iyo culeys kelli ah oo ah 663.43. Sida xudunta u ah falcelinta redox-ka, xooga saaristeeda ayaa si toos ah u go'aamisa waxtarka dheef-shiid kiimikaadka tamarta gacanta waxaana loo yaqaanaa "lacagta tamarta gacanta".
Tilmaamaha qaybinta dabiiciga ah:
Kala duwanaanshiyaha unugyada: Waxyaabaha ku jira unugyada myocardial waa kuwa ugu sarreeya (qiyaastii 0.3-0.5 mM), oo ay ku xigto beerka, iyo tan ugu hooseeysa ee maqaarka (hoos u dhaca 50% 20 sano kasta oo da'da);
Foomka jiritaanka: oo ay ku jiraan qaabka oksaydhisku (NAD⁺) iyo qaabka la dhimay (NADH), iyo dheelitirnaanta firfircoon ee saamiga u dhexeeya labadaba waxay ka tarjumaysaa xaaladda dheef-shiid kiimikaad.
● Ilaalinta shucaaca eeβ-NAD.
Kordhi heerka badbaadada unugyada tarma ee hematopoietic ka dib soo-gaadhista shucaaca 3 jeer, oo ka hel dareenka muhiimka ah mashruuca caafimaadka hawada sare ee NASA.
Isha diyaarinta: Laga soo bilaabo soo saarista noolaha ilaa kacaanka bayoloji synthetic
1. Habka soo saarista dhaqameed
Qalabka ceeriin: unugyada khamiirka (content 0.1% -0.3%), beerka xoolaha;
Habka: burburinta ultrasonic → ion beddelka chromatography → qaboojinta qalajinta,β-NADnadiifnimada ≥ 95%.
2. Enzyme catalytic synthesis (habsocodka guud)
Substrate: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Faa'iidada: Tiknoolajiyada enzyme-ka ee aan dhaqdhaqaaqa lahayn waxay kordhin kartaa wax-soo-saarka β-NAD ilaa 97%.
3. Bayoloji synthetic (jihada mustaqbalka)
Escherichia coli oo hidda-wadaha tafatiray:Nooc la farsameeyey oo uu dhisay ChromaDex, USA, oo leh dhalidda halsano ah 6 g/L;
Dhaqanka unugyada dhirta: Nidaamka xididka timaha leh ee tubaakada wuxuu xaqiiqsadaa wax-soo-saarka baaxadda leh ee NAD horudhaca NR.
● Maxay yihiin faa'iidooyinka ku jiraβ-NAD?
1. Farsamaynta xudunta u ah gabowga
Daar Sirtuins:Kordhi SIRT1/3 dhaqdhaqaaqa 3-5 jeer, hagaaji dhaawaca DNA, oo kordhi cimriga khamiirka 31%;
Xoojinta Mitochondrial:Daraasadaha caafimaadku waxay muujinayaan in dadka da'doodu u dhaxayso 50-70 ay ku kordhiyaan 500 mg NMN maalin kasta, iyo wax soo saarka ATP ee muruqa ayaa kordhay 25% 6 toddobaad ka dib.
2. Ilaalinta neerfaha
Cudurka Alzheimers:Soo celinta heerarka NAD⁺ neuronal waxay yarayn kartaa dhigaalka β-amyloid, iyo shaqada garashada ee moodooyinka jiirka ayaa horumariya 40%;
Cudurka Parkinson: β-NADKa ilaali dopaminergic neurons iyada oo loo marayo joojinta PARP1.
3. Faragelinta cudurka dheef-shiid kiimikaadka
Sonkorowga:Kobcinta dareenka insulin, tijaabooyinka jiirka buuran ayaa muujinaya hoos u dhaca 30% ee sonkorta dhiigga;
Ilaalinta wadnaha iyo xididada:Hagaajinta shaqada endothelial, oo yaree aagga xuubka atherosclerotic 50%.
● Maxay yihiin Codsiyadaβ-NAD?
1. Beerta caafimaadka
Daawooyinka ka hortagga gabowga: Diyaargarawyo badan oo NMN ah ayaa FDA u cadeeysay dawooyinka agoonta ah ee mitochondrial myopathy;
Cudurada Neurodegenerative: NAD⁺ cirbadeynta xididada ayaa gashay tijaabooyinka bukaan-socodka ee Wajiga II (tilmaamaha cudurka Alzheimers).
2. Cuntooyinka shaqada leh
Kaabista afka: β-NADsida NAD precursor (NR/NMN) kaabsooshadu waxay leeyihiin iib sannadeed ka badan $500 milyan.
Nafaqada ciyaaraha:Hagaajinta dulqaadka ciyaartoyda, waxaana jira qaar ka mid ah NAD optimizeers suuqa si loo horumariyo waxqabadka isboortiga.
3. Hal-abuurka qurxinta
Nuxurka gabowga:0.1%-1% NAD⁺ adag, oo la tijaabiyay si loo yareeyo laalaabka qoto dheer ee 37%;
Daryeelka madaxaShaqaysii unugyada tarma ee timaha, oo ku dar kuwa xoojiya NAD shaambada ka hortagga timaha.
4. Beeraha iyo cilmi baarista
Caafimaadka xoolaha:Ku darida horudhaca NAD si loo beero quudinta waxay kordhisaa tirada doofaarka 15%;
Ogaanshaha noolaha:Saamiga NAD/NADH waxa loo istcimaalaa calaamad u ah xaaladda dheef-shiid kiimikaadka unugga ee baaritaanka kansarka hore.
●Sahayda CUSUBβ-NADBudada
Waqtiga boostada: Juun-17-2025
