● Chiiβ-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) ndiyo coenzyme inokosha inowanikwa mumasero mapenyu ose, ine molecular formula yeC₂₁H₂₇N₇O₁₄P₂, uye molecular weight ye663.43. Seye musimboti mutakuri we redox reactions, kusungirirwa kwayo kunotarisisa kushanda zvakanaka kweserura simba metabolism uye inozivikanwa se "cellular energy currency".
Natural kugovera maitiro:
Kusiyana kweTissue: Zviri mumasero emyocardial ndiyo yakakwirira (inenge 0.3-0.5 mM), inoteverwa nechiropa, uye yakaderera muganda (inoderera ne50% makore ose e20 nezera);
Kuvepo kwechimiro: kusanganisira oxidized fomu (NAD⁺) uye yakaderedzwa fomu (NADH), uye chiyero chesimba chereshiyo pakati pezviviri zvinoratidza mamiriro emagetsi metabolism.
● Radiation Kudzivirirwa kweβ-NAD.
Wedzera huwandu hwekupona kwehematopoietic stem maseru mushure mekuratidzwa nemwaranzi nekatatu, uye gamuchira kutariswa kwakakosha kubva kuNASA's space hutano chirongwa.
Kugadzirira kunobva: Kubva kubiological kutorwa kuenda kune synthetic biology shanduko
1. Traditional extraction method
Raw zvinhu: mbiriso masero (zviri mukati 0.1% -0.3%), chiropa chemhuka;
Maitiro: ultrasonic kupwanya → ion exchange chromatography → kuomesa nechando,β-NADkuchena ≥ 95%.
2. Enzyme catalytic synthesis (mainstream process)
Substrate: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Zvakanakira: Immobilized enzyme tekinoroji inogona kuwedzera goho re β-NAD kusvika 97%.
3. Synthetic biology (gwara remangwana)
Gene-edited Escherichia coli:Injiniya yemhando yakagadzirwa neChromaDex, USA, ine goho rekuvirisa re6 g/L;
Kudyara sero tsika: Iyo fodya ine mvere midzi system inoziva yakakura-yakakura kugadzirwa kweNAD precursor NR.
● Ndezvipi zvinobatsira zveβ-NAD?
1. Anti-kuchembera core mechanism
Activate Sirtuins:Wedzera SIRT1/3 chiitiko ne3-5 nguva, gadzirisa DNA kukuvadzwa, uye wedzera mbiriso hupenyu ne31%;
Kugonesa Mitochondrial:Zvidzidzo zvekiriniki zvinoratidza kuti vanhu vane makore 50-70 makore vanowedzera 500 mg NMN zuva nezuva, uye tsandanyama ATP kugadzirwa kunowedzera ne25% mushure memavhiki matanhatu.
2. Neuroprotection
Chirwere cheAlzheimer:Kudzoreredza neuronal NAD⁺ mazinga anogona kuderedza β-amyloid deposition, uye cognitive basa remhando yemakonzo inovandudza ne40%;
Chirwere cheParkinson: β-NADDzivirira dopaminergic neurons kuburikidza nePARP1 inhibition.
3. Kupindira kwechirwere cheMetabolic
Chirwere cheshuga:Kuvandudza insulin senitivity, obese mouse kuedza kunoratidza kuderera kwe30% mushuga yeropa;
Kudzivirirwa kwemoyo:Kuvandudza endothelial basa, uye kuderedza nzvimbo yeatherosclerotic plaques ne50%.
● Ndeapi Maapplication Eβ-NAD?
1. Munda wezvokurapa
Anti-aging drugs: Multiple NMN gadziriro dzakasimbiswa semishonga yenherera neFDA nokuda kwemitochondrial myopathy;
Neurodegenerative zvirwere: NAD⁺ jekiseni remutsinga rapinda muChikamu II chekiriniki miedzo (zviratidzo zvechirwere cheAlzheimer).
2. Zvokudya zvinoshanda
Oral supplements: β-NADseNAD precursor (NR/NMN) capsules ane kutengesa kwegore kunodarika $500 miriyoni.
Zvokudya zvemitambo:Kuvandudza kutsungirira kwevatambi, uye kune mamwe NAD optimizers pamusika kuti uvandudze kuita kwemitambo.
3. Cosmetic innovation
Anti-aging essence:0.1% -1% NAD⁺ yakaoma, yakaedzwa kuti ideredze wrinkle kudzika ne37%;
Kuchengeta ganda remusoro:Shandisa bvudzi follicle stem masero, uye wedzera NAD zvinowedzera kune anti-bvudzi kurasikirwa shampoo.
4. Kutsvakurudza kwekurima nesayenzi
Utano hwemhuka:Kuwedzera NAD precursors kudyara chikafu kunowedzera huwandu hwenguruve ne15%;
Kuonekwa kweBiological:NAD/NADH chiyero chinoshandiswa sechiratidzo chesero metabolic mamiriro ekutanga kenza kuongororwa.
●NEWGREEN Supplyβ-NADUpfu
Nguva yekutumira: Jun-17-2025
