Zinc Pyrithione (ZPT): A Multi-Domain Fungicide

 

●Chii Zinc Pyrithione?

Zinc pyrithione (ZPT) is organic zinc complex ine molecular formula ye C₁₀H₈N₂O₂S₂Zn (molecular weight 317.7). Iro zita rinobva kune yakasikwa midzi zvinongedzo zveAnnaceae chirimwa Polyalthia nemoralis, asi indasitiri yemazuva ano yatora makemikari synthesis kuigadzira. Muna 2024, maitiro eChina ane patented akatyora mukati mekuchena bhodhoro, uye iyo yekusachena crotonic acid yakadzorwa pazasi 16ppm kuburikidza nemethanol-acetone graded crystallization, uye kuchena kwegiredhi remishonga kwakawedzera kusvika 99.5%.

 

Zvenyama nemakemikari zvivakwa:

Kuonekwa uye kunyunguduka: kuchena kune zvishoma yellow crystalline powder, inenge isingasviki mumvura (<0.1g / 100mL), zvishoma zvishoma mu ethanol, solubility mu polyethylene glycol inogona kusvika 2000mg / kg;

Kugadzikana kunokanganisa: kunzwira kuchiedza uye oxidants, nyore kuderedzwa ne ultraviolet mwenje, brown packaging inodiwa; dissociation kukundikana pa pH <4.5 kana> 9.5, yakakwana pH ndeye 4.5-9.5;

Thermal decomposition yakakosha poindi: yakagadzikana kwemaawa 120 pa100 ℃, asi inoora nekukurumidza pamusoro pe240 ℃;

Kusapindirana: precipitates ne cationic surfactants, chelates uye discolors nesimbi / mhangura ions (kunyange 1ppm inogona kuita kuti chigadzirwa chive chero).

 

●Chii IzvoBenefitsOf Zinc Pyrithione ?

ZPT inowana hupamhi-hukuru sterilization (inoshanda kumarudzi makumi matatu nemaviri ehutachiona) kuburikidza neimwe nzira yekutsinhanisa ion, kunyanya kuMalassezia, honzeri yedandruff, ine MIC yakaderera se8ppm:

 

1. Ion Gradient Kuparadza

Munzvimbo ine acidic, H⁺ inopinza mubhakitiriya uye K⁺ inobuda, uye munzvimbo ine alkaline, Na⁺/Mg²⁺ inotsiviwa, iyo inoparadzanisa microbial nutrient transport system;

 

2. Kuparara kweSero Membrane

Kupinza mu phospholipid bilayer, kuwedzera membrane permeability uye kukonzera intracellular zvinhu kubuda;

 

3. Enzyme Activity Inhibition

Kuvhara ketani yekutakura erekitironi uye inhibiting akakosha ma enzymes esimba metabolism (senge ATP synthase).

 

Kuongororwa kwekiriniki: Mushure mekushandisa shampoo ine 1.5%zincpyrithionekwemavhiki mana, dandruff inoderedzwa ne90%, uye kudzoka kweseborrheic dermatitis kunoderedzwa ne60%.

 

 

●Chii IzvoApplicationOf Zinc Pyrithione?

1. Daily Chemical Field:

Inogona kushandiswa mu70% ye-anti-dandruff shampoo, ine kuwedzera kwe 0.3% -2%;

 

Zvimwe zvigadzirwa zvekuzora zvinogona kudzora kushandiswa kwe zinc pyrithione uye inoda kunyorwa "suka mushure mekushandisa". Unogona kushandisa chimwe chigadzirwa piroctone ethanolamine (OCT).

 

2. Industrial Anti-Corrosion:

Anti-fouling revolution: yakasanganiswa ne cuprous oxide kuti inhibit barnacle attachment uye kuderedza kushandiswa kwemafuta echikepe ne12%;

 

3. Zvekurima Nezvekushandisa:

Kudzivirirwa kwembeu: 0.5% coating agent inodzivirira chakuvhe uye inowedzera kumera ne18%;

 

Antibacterial fiber: jira repolyester rakabatanidzwa rine antibacterial rate ye> 99%.

 

4. Kuwedzerwa Kurapa:

Zvitatu-zvikonzero bvunzo hazvina kunaka (hapana carcinogenicity/teratogenicity/ mutagenicity), inoshandiswa kubura gel uye antibacterial coating yemidziyo yekurapa.

 

●Mazano:

Kunyange zvazvo acute oral toxicityof zinc pyrithioneyakaderera (LD₅₀> 1000mg/kg mumakonzo), yambiro yekiriniki mumakore achangopfuura:

 

Uturu hweganda: kusangana kwenguva refu kunokonzera allergic dermatitis, uye kusangana kwemaziso kunogona kukonzera conjunctivitis;

 

Absolute contraindications:

→ Ganda rakaputsika (permeability inowedzera katatu, zvichiita kuti systemic kuratidzwa);

→ Vakadzi vane pamuviri nevana (ropa-brain barriers kupinza data rakashaikwa);

 

Kudyidzana kwezvinodhaka: Dzivisa kushandiswa pamwe chete neEDTA (chelating zinc ions inoderedza kushanda kwezvinodhaka).

 

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