● ChiiSclareol ?
Sclareol, zita remakemikari (1R,2R,8aS) -decahydro-1-(3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, molecular formula C₂₀H₃₆O₂, molecular uremu 308.350-308 nhamba 308.350-308-CAS. Iyo bicyclic diterpenoid komboni, ine chitarisiko chewhite crystalline poda, nzvimbo yekunyunguduka 95-105 ℃, poindi yekuvira 398.3 ℃, isinganyungudika mumvura, uye inonyungudika nyore muorganic solvents. Chimiro chayo chikuru ndechekuti ine kunhuhwirira kwenguva refu kwakafanana neambergris, ine kunhuhwirira kwakapfava uye kupararira kwakasimba, zvichiita kuti ive yakanaka mbishi zvinhu zvemhando yepamusoro pefuyumu.
Nzvimbo yakasikwa inonyanya kuve inflorescence uye madzinde uye mashizha emuti weLamiaceae Salvia Sclarea L., inorimwa pamwero mukuru munzvimbo dzakakwirira dzemakomo sekuchamhembe kweShaanxi neHonghe, Yunnan, China. Nekuda kwemusiyano mukuru wetembiricha pakati pemasikati neusiku uye hunyoro hwakakodzera, iyo clarysol munzvimbo idzi dzinogadzira ndeyekuchena kwepamusoro uye kunhuhwirira kwakachena.
Pane nzira dzakati wandei dzekugadzira sclareol:
1. Chemical synthesis
Kazhinji,sclareolchidimbu chinoshandiswa sechinhu chakabikwa chekubvisa uye kuchenesa. Iyo sclareol yakasara mushure mekubviswa kwemafuta yakanyungudika mu ethanol, uye sclareol inonaya muchimiro chetsono chena mushure mekudzika-kupisa kwechando, kusefa, activated kabhoni kurapwa, dilution uye mamwe matanho. Mushure me centrifugal dehydration, vacuum drying, kupwanya uye kuongorora, sclareol ine doro rakawanda rinogona kuwanikwa.
2. Biosynthesis
Kuvakwa kwefekitori yebrewer's yeast cell: Muchidzidzo ichi, maviri synthases TPS neLPPs mune sage akatanga kusanganiswa kune yeast gene, iyo yakawedzera kugadzirwa kwesclareol. Zvadaro N-terminus yeTPS-LPPS yakabatanidzwa kune chikamu cheprotein yemaltose inosunga kuti iwedzere kuvandudza kugadzikana kwe enzyme uye kuwedzera goho zvakare. Zvadaro, boka rekutsvagisa rakakamura nzira yese yemetabolism kuita mamodule matatu: iyo yepakati metabolic nzira yekupa acetyl coenzyme A, iyo isoprenoid biosynthesis nzira uye regulatory factor module yekuchinja system. Ne in situ kudzoreredza nekudzimwa kwemamwe majini ane hukama, chassis dhizaini inogona kupa nemazvo acetyl-CoA neNADPH yakavakwa, uye goho re sclareol rakawedzera kuvandudzwa nekuwedzeredza mamwe majini. Pakupedzisira, mhedzisiro yemodule yega yega pane synthesis ye sclareol yakaongororwa kuburikidza neiyo metabolic profiles yeinjiniya strain, uye zvakaonekwa kuti matatu modules aive ne synergistic effect. Fed-batch fermentation yakaitwa mumashake flasks uye bioreactors, uye pakupedzisira sclareol yakanyatsogadzirwa muSaccharomyces cerevisiae ichishandisa glucose seyakagadzirwa, ine goho re11.4 g/L.
●Chii IzvoBenefitsOf Sclareol ?
Zvidzidzo zvenguva pfupi yapfuura zvakaratidza iyo yakawanda-dimensional biological chiitiko che sclareol, kunyanya mumunda wepakati tsinga system zvirwere:
1. Anti-inflammatory uye neuroprotective:
Inhibits kunyanya kushandiswa kwe microglia, inoderedza mazinga ehutachiona hwezvinhu TNF-α uye IL-1β, inobvisa kusagadzikana kwekufamba muParkinson's model mice, uye inodzivirira dopamine neurons;
Kuvandudza cognitive basa mumhando dzechirwere cheAlzheimer. Chiyero che 50-200mg / (kg·d) chinogona kudzivisa kushandiswa kweastrocytes muuropi uye kuderedza kuiswa kwe-β-amyloid protein.
2. Anticancer chiitiko:
Iyo ine yakasimba cytotoxicity kune kenza maseru mitsara senge mbeva leukemia (P-388) uye yemunhu epidermal carcinoma (KB), uye inodzivirira bundu kupararira nekuita apoptosis.
3. Antibacterial uye antioxidant:
Iine huwandu hwakawanda hwekudzivirira kwekukura kwebhakitiriya, uye kushanda kwayo kweantioxidant kakapetwa makumi mashanu kune yevhitamini E, iyo inokodzera mapfekero emaronda uye anti-kuchembera ganda rekuchengetedza zvigadzirwa.
●Chii IzvoApplicationOf Sclareol ?
1. Indasitiri yekunhuhwirira nekunhuhwirira:
Sechinhu chikuru chekugadzirwa kweambergris, inotsiva ambergris echisikigo kubva mungozi yekutsakatika. Chinhu chiduku chinoshandiswa zvakananga muzvinonhuwira zvepamusoro-soro kuti zvipe kunhuhwirira kwekunzwa kunogara uye kwakaiswa.
2. Tsvagiridzo yemishonga nekusimudzira:
Chirwere cheAlzheimer/Parkinson's disease drug: oral capsules kana jekiseni akapinda mutsvakurudzo yepreclinical, inotarisa kudziviswa kweuroinflammation;
Anti-cancer adjuvant therapy: yakasanganiswa nechemotherapy mishonga yekuwedzera bundu cell kuuraya.
3. Cosmetics uye chikafu:
Zvigadzirwa zvekuchengetedza ganda zvinorwisa kuchembera: wedzera 0.5% -2% kuti inhibit photoaging uye kuderedza ultraviolet erythema;
Masikirwo ekuchengetedza: anoshandiswa mukudya zvine mafuta kuwedzera hupenyu hwesherufu, uye akachengeteka kupfuura zvigadzirwa zvemakemikari.
●NEWGREEN Supply High QualitySclareolUpfu
Nguva yekutumira: Jul-18-2025
