Ivermectin: A New Antiparasitic Mushonga

●Chii Ivermectin?

Ivermectin inonzi semi-synthetic macrolide antibiotic yakabva mukuvirisa uye kucheneswa kweStreptomyces avermitilis. Inonyanya kuve nezvikamu zviviri: B1a (≥80%) uye B1b (≤20%). Yayo molecular formula ndeye C48H74O14, molecular uremu ndeye 875.09, uye nhamba yeCAS ndeye 70288-86-7.

Muna 2015, vakawanwa William C. Campbell naSatoshi Omura vakahwina Mubairo weNobel muPhysiology kana Medicine nekuda kwekubatsira kwavo mukurwisa kusaona kwenzizi uye elephantiasis.

Zvenyama uye zvemakemikari zvinhu

Properties: chena kana chiedza yellow crystalline upfu, kunhuhwirira;

Solubility: inonyungudika nyore muorganic solvents senge methanol, ethanol, acetone, uye inenge isinganyungudike mumvura (solubility inenge 4μg/mL);

Kugadzikana: hazvisi nyore kuora pakupisa kwekamuri, asi zviri nyore kuderedza muchiedza, zvinoda kuchengetwa munzvimbo yakavharwa uye isina chiedza, uye kuchengetedza kwenguva refu kunoda nzvimbo yakadzika yekushisa ye2-8 ℃;

●Chii IzvoBenefitsOf Ivermectin ?

Ivermectin inorwisa hutachiona hwetsinga system chaizvo kuburikidza nenzira mbiri:

1. Inokurudzira kusunungurwa kweinhibitory neurotransmitter γ-aminobutyric acid (GABA) kuvharidzira nerve signal transmission;

2. Inovhura glutamate-gated chloride ion channels kuti iite hyperpolarization uye kuremara kwenyama dzeparasite.

Kugona kwaro mukuuraya nematodes (zvakadai semaroundworms nehookworms) uye arthropods (semite, zvikwekwe, nenda) zvakakwira kusvika pa94% -100%, asi haishande pakurwisa honye neflukes.

●Chii IzvoApplicationOf Ivermectin?

1. Veterinary munda (chaiyo chipimo chemusiyano)

Mombe/makwai: 0.2mg/kg (subcutaneous injection kana oral administration), inogona kubvisa gastrointestinal nematodes, lung filaria uye scabies pamusoro pemuviri;

Nguruve: 0.3mg/kg (injection intramuscular), chiyero chekutonga cheroundworms uye scabies inenge 100%;

Imbwa nekatsi: 6-12μg/kg kudzivirira uye kurapa heartworms, 200μg/kg kuuraya nzeve mite;

Huku: 200-300μg/kg (oral administration) inoshanda kurwisa huku roundworms nemabvi mite.

2. Kurapa kwevanhu

Ivermectinmushonga wekutanga weWorld Health Organisation, unonyanya kushandiswa ku:

Onchocerciasis (kupofomara kwerwizi): 0.15-0.2mg/kg dosi imwe chete, iyo microfilariae clearance rate inodarika 90%;

Stregostrongyloidiasis: 0.2mg/kg kamwe chete;

Ascaris uye whipworm zvirwere: 0.05-0.4mg/kg kurapwa kwenguva pfupi.

3. Mishonga yekurima

Semushonga wezvipembenene, unoshandiswa kudzora zvipembenene zvezvirimwa, zvipfukuto zvediamondback, vanochera mashizha, zvichingodaro, uye zvine zvisaririra zvakaderera.

●Kuchengetedza uye Zvinetso

Ivermectinyakachengeteka kune mhuka dzinoyamwisa (zvakaoma kupinda mukati meropa-brain barriers), asi pachine contraindications:

Maitiro asina kunaka: Dzimwe nguva musoro, kuputika, kuwedzera kwenguva pfupi mumakemikari echiropa, uye kuwandisa kwepamusoro kunogona kukonzera ataxia;

Mhando dzekunzwa kusiyana: Imbwa dzinofudza nedzimwe mhando dzembwa dzinogona kusangana neurotoxicity yakaoma;

Muchetura wekubereka: Kuedza kwemhuka kunoratidza kuti madosi makuru ane njodzi yeteratogenicity (cleft palate, claw deformity).

Dambudziko repasi rose rekuramba kweparasite riri kuramba richikura. Chidzidzo che2024 chakaratidza kuti kusanganiswa kweivermectin uye albendazole kunogona kuvandudza kushanda kwekurwisa filariasis. Makambani mazhinji emishonga pasi rose ari kusimudzira kuvandudzwa kwehunyanzvi hwekugadzira mishonga, uye kuchena kwasvika pa99%.

● NEWGREEN Supply High QualityIvermectinUpfu