● ChiiChenodeoxycholic Acid ?
Chenodeoxycholic Acid (CDCA) ndechimwe chezvinhu zvikuru zvinoumba vertebrate bile, inoverengera 30% -40% yehuasidhi yemunhu, uye zvirimo zvakakwirira mu bile rehanzi, madhadha, nguruve nedzimwe mhuka.
Kubudirira mune yemazuva ano yekubvisa tekinoroji:
Supercritical CO₂ kudhirowa: kudhirowa pasi pekushisa kwakadzika uye yakanyanya kudzvanywa mamiriro ekudzivisa organic solvent masara, uye kuchena kunogona kusvika kupfuura 98%;
Microbial fermentation method: kushandisa genetically engineered strains (seEscherichia coli) kugadzira CDCA, mari yacho inoderedzwa ne40%, iyo inoenderana nemaitiro ekugadzirwa kwemishonga yakasvibirira;
Chemical synthesis nzira: kushandisa cholesterol seyakatangira, inowanikwa kuburikidza neakawanda-nhanho maitiro, anokodzera yakakwira-kuchena kwemishonga-giredhi zvigadzirwa.
Zvenyama nemakemikari zvimiro zveChenodeoxycholic Acid :
Zita remakemikari: 3α, 7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Molecular formula: C₂₄H₄₀O₄
Molecular uremu: 392.58 g/mol
Kuonekwa: white crystalline powder
Solubility: inonyungudika zvishoma mumvura, inonyungudika nyore mu ethanol, ether, chloroform
Nzvimbo yekunyungudika: 165-168 ℃
Kugadzikana: inonzwa kuchiedza uye kupisa, inoda kuiswa firiji kure nechiedza (2-8 ℃)
● Ndezvipi zvinobatsira zveChenodeoxycholic Acid ?
1. Kuparara kweCholesterol Gallstones
Mechanism: inhibit chiropa HMG-CoA reductase, kuderedza cholesterol synthesis, kukurudzira bile acid secretion, uye zvishoma nezvishoma kunyungudutsa cholesterol gallstones;
Clinical data: 750mg CDCA pazuva kwemwedzi 12-24, gallstone dissolution rate inogona kusvika 40% -70%.
2. Kurapwa kwePrimary Biliary Cholangitis (Pbc)
Mishonga yekutanga: FDA yakabvumira Chenodeoxycholic Acid CDCA yePBC, inovandudza zviratidzo zvekushanda kwechiropa (ALT / AST yakaderedzwa neanopfuura 50%);
Combination therapy: yakasanganiswaChenodeoxycholic Acidne ursodeoxycholic acid (UDCA), kushanda kunovandudzwa ne30%.
3. Regulation Of Metabolic Diseases
Kuderedza lipids yeropa: kuderedza serum yakazara cholesterol (TC) uye pasi-density lipoprotein (LDL);
Anti-diabetes: kuvandudza insulin senitivity, kuedza kwemhuka kunoratidza kuti shuga yeropa inodonha ne20%
4. Anti-Inflammatory And Immune Regulation
Inhibisa NF-κB nzira uye kuderedza kusunungurwa kwezvinhu zvinopisa (TNF-α, IL-6);
Mishonga yemakiriniki yakaratidza kuti chiyero chekuvandudza kwechiropa fibrosis kune varwere vane kwete-doro fatty chiropa chirwere (NAFLD) inopfuura 60%.
● Ndeapi Maapplication EChenodeoxycholic Acid ?
1. Medical Field
Gallstone kurapwa: CDCA mapiritsi (250mg / tablet), zuva rega rega 10-15mg / kg;
Kurapa kwePBC: gadziriro dzakabatanidzwa neUDCA (zvakadai seUrsofalk®), kutengesa kwegore negore kunodarika US$500 mamiriyoni;
Anti-tumor research: inhibiting chiropa cancer cell kuwanda nekudzora FXR receptors, kupinda Phase II kiriniki miedzo.
2. Functional Foods And Health Products
Mapiritsi ekudzivirira chiropa: komputa formula (CDCA + silymarin), kuderedza doro kukuvara kwechiropa;
Lipid-kudzikisa capsules: synergistic ine tsvuku mbiriso yemupunga inobvisa kugadzirisa ropa lipid metabolism.
3. Kuchengeta Mhuka Uye Aquaculture
Zvokudya zvinowedzera: kunatsiridza zvipfuwo uye huku mafuta metabolism, kuderedza mudumbu mafuta mwero;
Utano hwehove: kuwedzera 0.1%chenodeoxycholic acidkuwedzera kurwisa chirwere checarp uye kuwedzera chiyero chekupona ne15%.
4. Zvizoro uye Personal Care
Anti-inflammatory essence: 0.5% -1% kuwedzera, kunatsiridza acne uye kunzwa kweganda;
Kuchengeta kwemusoro: inhibit Malassezia uye kuderedza dandruff chizvarwa.
Kubva pachinyakare kuburitsa bile kuenda ku microbial synthesis, chenodeoxycholic acid iri kuita shanduko kubva ku "natural ingredient" kuenda "mushonga chaiwo". Nekudzika kwekutsvagisa pamusoro pezvirwere zvemetabolism uye anti-bundu, CDCA inogona kuve iyo yakakosha yekurapa chirwere chechiropa, chikafu chinoshanda uye biomaterials, ichitungamira mutsva we100 bhiriyoni hutano indasitiri.
● NEWGREEN SupplyChenodeoxycholic AcidUpfu
Nguva yekutumira: Jun-11-2025
