●Chii Bilirubin?
Bilirubin chigadzirwa chekuparara kwemasero matsvuku eropa akwegura. Anenge mamiriyoni maviri emasero matsvuku eropa anoparara muspleen zuva rega rega. Iyo hemoglobin yakaburitswa inoshandurwa enzymatic kuita mafuta-soluble indirect bilirubin, inozoshandurwa kuita mvura-inonyungudika yakananga bilirubin nechiropa uye pakupedzisira inoburitswa muura kuburikidza ne bile. Chero chipi nechipi chisina kujairika mune iyi metabolic cheni (yakadai sehemolysis, kukuvara kwechiropa kana bile duct obstruction) inogona kutungamira mukuunganidzwa kwebilirubin uye kukonzera jaundice.
Tsvagiridzo yazvino yakawana kuti kana iyo bilirubin yakasungwa≥17.05μmol / L, kushamwaridzana pakati pechirwere cheshuga uye sitiroko inogona kuvharwa, uye njodzi yekurohwa muvarume vane chirwere cheshuga inoderedzwa ne2.67 nguva. Iyo nzira ndeyekudzivisa yakakwirira-sensitivity C-reactive protein uye systemic immune immune index index, kuisa mabhureki pa "dutu rinoputika".
Bilirubin inotorwa kubva munguruve uye shark chiropa, mombe gallbladder uye brainstem. Isu takawana mabudiro kuburikidza nehunyanzvi hwekuvandudza tekinoroji:
Supercritical CO₂ kubviswa: chengetedza zvinongedzo zvinoshanda pasi peyakadzika tembiricha nharaunda, dzivirira zvinonyungudutsa zvinosara, uye wedzera kuchena kune anopfuura 98%;
Biological enzymatic hydrolysis process: inotungamira shanduko yebilirubin glycosides kuita inoshanda aglycones, ichiwedzera bioavailability ne50%.
●Ndezvipi zvinobatsira zveBilirubin ?
1. Antioxidant kudzivirira
Bilirubin yakakosha endogenous antioxidant mumuviri, iyo inogona kunyatso kudzikamisa mahara radicals (senge superoxide uye hydrogen peroxide) uye kuderedza kukuvadzwa kweiyo oxidative kusagadzikana kune cell membrane, mapuroteni uye DNA. Zvidzidzo zvakaratidza kuti kudzika kwakadzika kwebilirubin kunogona kuwedzera kudzivirira kwesero kubva mukukuvadzwa kweoxidative nekuita kuti antioxidant siginecha nzira (senge Nrf2 nzira), uye inogona kutoderedza njodzi yeatherosclerosis uye neurodegenerative zvirwere.
2. Immunomodulatory function
Bilirubininogona kugadzirisa mhinduro dzekudzivirira nekudzivirira kusunungurwa kwezvinhu zvinopisa (zvakadai seTNF-α uye IL-6). Inogona kuderedza kukuvadzwa kwematishu anokonzerwa nekuzvimba kwakanyanya uchichengetedza kuenzana kwesimba rekudzivirira. Semuenzaniso, yakakwira zvinyoro bilirubin mune yemuviri jaundice yevachangozvarwa inogona kubatsira kuderedza njodzi yekutapukirwa kuburikidza nemuchina uyu. Zvisinei, kuwandisa kwakanyanyisa kunogona kutadzisa kushanda kwemasero ekudzivirira muviri uye kuwedzera kukanganisa kwehutachiona.
3. Sero uye neuroprotection
Bilirubin ine chinhu chakakosha chekudzivirira pane tsinga system. Inogona kuyambuka chipingamupinyi cheropa-uropi uye kudzivirira neurons kubva kune ischemia kana maronda anoderera nekudzivisa glutamate excitotoxicity uye kuderedza oxidative kukuvara. Mukuwedzera, bilirubin inogonawo kuderedza kukanganisa kwemasero echiropa, myocardial masero, nezvimwewo pasi pe hypoxia kana kusvibiswa kwehupfu, uye kuchengetedza nhengo yemuviri.
4. Kurudzira metabolism uye excretion cycle
Iyo metabolic process yebilirubinndicho chinongedzo chakakosha mukudzokorodza hemoglobin mumuviri. Mushure mekunge hemoglobin mukuchembera masero matsvuku eropa aora kuita bilirubin, inoda kusanganiswa nechiropa uye kuburitswa muura ne bile. Mabhakitiriya emudumbu anoashandura kuita urobilinogen, chikamu chayo chinodzokororwa (enterohepatic circulation), uye mamwe acho anoburitswa netsvina. Kutenderera uku hakungobatsiri chete kubvisa tsvina yemetabolism, asiwo inopindirana nemaruva emudumbu kukanganisa chiyero chemetabolism.
5. Kukuvadza kwemazinga asina kujairika
Yakawandisa bilirubin: Inogona kukonzera jaundice (yellowing yeganda uye sclera), iyo inowanzoitika muhepatitis, biliary obstruction kana hemolytic zvirwere. Kana bilirubin yemahara yanyanya kukwira, inogona kupfuura nemuropa-brain barriers uye kukonzera neonatal kernicterus (kukuvara kwehuropi).
Yakanyanya kuderera bilirubin: Zvidzidzo zvenguva pfupi yapfuura zvakawana kuti kuwedzera kunyoro mubilirubin kunogona kuve nekudzivirira, nepo kuderera kwakanyanya kunogona kuve kwakabatana nenjodzi yemoyo yemoyo uye chirwere che autoimmune, asi iyo chaiyo nzira ichiri kuda kuongororwa.
●Chii chinonzi Medical Application Kuwedzera Bilirubin ?
1. Core pharmaceutical raw materials
Bilirubin ndiyo chikamu chikuru cheartificial bezoar uye inoshandiswa mumishonga inopfuura zana nemakumi matatu, yakadai seyemwoyo uye cerebrovascular zvinodhaka (85% inoshanda mukubvisa chirwere chemoyo) uye gadziriro yemenopausal regulation.
2. Nano gadziriro (BRNPs)
Kuburikidza nanocarrier tekinoroji, kushanda uye kunanga kwebilirubin kwakagadziridzwa zvakanyanya:
Acute gastric ulcer: chitosan-bilirubin (CS-BR), inodzivisa kuvharidzirwa kwezvinhu zvinopisa uye inokurudzira mucosal kuvandudzwa.
Chiropa chisiri-doro chine mafuta: polyethylene glycol-bilirubin (PEG-BR), inoderedza kuunganidzwa kwemafuta echiropa ne30%, uye inoderedza triglycerides ne40%.
Psoriasis: hydrogelbilirubin, inovandudza maronda eganda, pasina systemic toxicity ye corticosteroids
Stroke: TRPM2 chiteshi inhibitor A23, inovhara bilirubin neurotoxicity uye inoderedza infarct size.
Zvimwe zvinoshandiswa zvebilirubin: kupfuya mhuka, kuchengetedza kwezvakatipoteredza uye zvigadzirwa zvinoshanda
Aquaculture: Kuwedzera 4% bilirubin kudyisa kunowedzera kaviri kugadzirwa kwe shrimp chena uye kunowedzera kurema kwecarp ne 155.1%;
Chikafu chinoshanda: Anti-glycation oral liquid, yakasanganiswa neiyo antioxidant zvinhu zvebilirubin kunonoka kukwegura kweganda.
●NEWGREEN Supply BilirubinUpfu
Nguva yekutumira: Jun-09-2025
