●O le a Zinc Pyrithione?
Zinc pyrithione (ZPT) ose fa'alāpotopotoga zinc fa'akomepiuta ma le fua mole mole o le C₁₀H₈N₂O₂S₂Zn (mole mole mamafa 317.7). O lona igoa e sau mai a'a masani o le Annonaceae laau Polyalthia nemoralis, ae o pisinisi faʻaonaponei ua faʻaaogaina vailaʻau faʻasolosolo e gaosia ai. I le 2024, o le faiga pateni a Saina na malepelepe i le mama bottleneck, ma o le mama crotonic acid na pulea i lalo ifo o le 16ppm e ala i le methanol-acetone graded crystallization, ma ua faateleina le mama o vailaau i le 99.5%.
Amioga fa'aletino ma kemisi:
Faʻaaliga ma solubility: paʻepaʻe paʻepaʻe paʻepaʻe tioata samasama, toetoe lava a le mafai ona solu i le vai (<0.1g / 100mL), soluble i le ethanol, solubility i le polyethylene glycol e mafai ona oʻo i le 2000mg / kg;
Fa'aletonu le mautu: maaleale i le malamalama ma oxidants, faigofie ona faʻaleagaina e le malamalama ultraviolet, afifi lanu enaena manaʻomia; faʻaletonu faʻamaʻi i le pH <4.5 poʻo> 9.5, o le pH sili ona lelei o le 4.5-9.5;
Fa'alili fa'avevela vaega taua: mautu mo le 120 itula i le 100 ℃, ae vave ona pala i luga ole 240℃;
Le fetaui: fa'afefete fa'atasi ma cationic surfactants, chelates ma fa'aliga fa'atasi ma ion u'amea/apa (e o'o lava i le 1ppm e mafai ona fa'aoso le lanu samasama).
●O aFaamanuiagaO Zinc Pyrithione ?
E maua e le ZPT le fa'ama'iina o alaleo lautele (e fa'asagatau i le 32 ituaiga o meaola ninii) e ala i se faiga fa'atauva'a tulaga ese, aemaise lava mo Malassezia, o le tagata solitulafono o le dandruff, ma le MIC e maualalo ifo i le 8ppm:
1. Ion Gradient Fa'aleagaina
I se siosiomaga acidic, H⁺ o loʻo tuʻuina atu i totonu o siama ma K⁺ o loʻo gaosia, ma i se siosiomaga alkaline, ua suia Na⁺/Mg²⁺, lea e faʻaleagaina ai le microbial nutrient transport system;
2. Fa'aliga Membrane Selula
Fa'aofiina i totonu o le phospholipid bilayer, fa'atuputeleina le fa'aogaina o le membrane ma mafua ai le fa'aogaina o mea intracellular;
3. Enzyme Activity Inhibition
Puipuia le filifili felauaiga eletise ma taofia enzymes autu o le metabolism malosi (pei o le ATP synthase).
Su'esu'ega ile falema'i: A mae'a ona fa'aoga le shampoo e iai le 1.5%zincpyrithionemo le 4 vaiaso, o le dandruff ua faʻaitiitia i le 90%, ma o le toe foʻi mai o le seborrheic dermatitis e faʻaitiitia i le 60%.
●O aFa'aaogāgaOf Zinc Pyrithione?
1. Vailaau Fa'asaina i Aso Ta'itasi:
E mafai ona faʻaaogaina i le 70% o le shampoo anti-dandruff, faʻatasi ai ma le faʻaopoopoga o le 0.3% -2%;
O nisi o mea teuteu e mafai ona fa'agata ai le fa'aogaina o le zinc pyrithione ma e mana'omia le fa'ailoga "fa'amama pe a uma ona fa'aoga". E mafai ona e fa'aogaina le isi oloa piroctone ethanolamine (OCT).
2. Alamanuia Anti-Corrosion:
Anti-fouling revolution: faʻapipiʻi i le cuprous oxide e faʻalavelave ai le faʻapipiʻiina o paʻu ma faʻaitiitia ai le faʻaaogaina o suauu i le 12%;
3. Fa'ato'aga ma Mea:
Puipuiga o fatu: 0.5% faʻapipiʻi mea e puipuia ai le pala ma faʻateleina le fua o le germination e 18%;
Alava antibacterial: fa'apipi'i ie polyester o lo'o i ai le fua fa'ama'i e >99%.
4. Fa'aopoopo Fa'afoma'i:
Su'ega e tolu-mafua'aga e le lelei (leai se carcinogenicity/teratogenicity/mutagenicity), fa'aaogaina mo le fa'ama'i gel ma le antibacterial coating o masini faafomai.
●Fautuaga:
E ui lava o le ogaoga oona oonaof zinc pyrithionee maualalo (LD₅₀>1000mg/kg i isumu), lapata'iga falema'i i tausaga talu ai nei:
O'ona o le pa'u: fa'apa'i umi e mafua ai le dermatitis fa'ama'i, ma fa'afeso'ota'i laumata e mafai ona fa'atupu ai le conjunctivitis;
Contraindications atoatoa:
→ Pa'u pa'u (fa'ateleina fa'atupuina fa'a 3 taimi, e fa'atupu ai le fa'aalia o le tino);
→ Tina ma'itaga ma tamaiti (leai ni fa'amatalaga o le sao o le toto-fai'ai);
Fegalegaleaiga o fualaau faasaina: Aloese mai le faaaogaina tuufaatasi ma le EDTA (chelating zinc ions e faaitiitia ai le aoga o fualaau faasaina).
●NEWGREEN Sapalai Tulaga MaualugaZinc PyrithioneO le pauta
Taimi meli: Iul-09-2025
