● O le āChenodeoxycholic Acid ?
Chenodeoxycholic Acid (CDCA) o se tasi o vaega autu o le vertebrate bile, faʻamauina mo le 30% -40% o le gaʻo gaʻo tagata, ma o lona anotusi e maualuga tele i le talo o kusi, pato, puaa ma isi manu.
Fa'ato'aga i tekonolosi fa'aonaponei fa'aonaponei:
Supercritical CO₂ extraction: aveese i lalo o le maualalo o le vevela ma tulaga maualuga o le mamafa e aloese ai mai toega solvent organic, ma o le mama e mafai ona sili atu i le 98%;
Microbial fermentation method: faʻaaogaina faʻamaʻi faʻainisinia (e pei o le Escherichia coli) e faʻapipiʻi ai le CDCA, o le tau e faʻaititia e 40%, lea e ogatasi ma le tulaga o le gaosiga o vailaʻau lanumeamata;
Metotia fa'asologa o vaila'au: fa'aaogaina o le cholesterol e fai ma mea muamua, e maua mai i le tele-step reactions, talafeagai mo vaila'au-ma'a maualuga.
Fa'aletino ma kemisi oChenodeoxycholic Acid :
Igoa vaila'au: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Fuafuaga mole: C₂₄H₄₀O₄
mamafa mole: 392.58 g/mol
Fa'aaliga: pa'epa'e tioata pa'epa'e
Solubility: soluble teisi i le vai, faigofie soluble i ethanol, eter, chloroform
Liu liusuavai: 165-168℃
Mausalī: maaleale i le malamalama ma le vevela, e manaʻomia le faʻaaisa mai le malamalama (2-8 ℃)
● O ā aogā o leChenodeoxycholic Acid ?
1. Fa'amavaega ole Cholesterol Gallstones
Mechanism: taofia le ate HMG-CoA reductase, faʻaitiitia le faʻaogaina o le cholesterol, faʻaleleia le faʻaogaina o le talo, ma faʻasolosolo malie le faʻamavaeina o gallstones cholesterol;
Faʻamatalaga faʻapitoa: 750mg CDCA i le aso mo le 12-24 masina, e mafai ona oʻo atu i le 40% -70% le faʻamavaeina o gallstone.
2. Togafitiga ole Primary Biliary Cholangitis (Pbc)
Laina muamua vailaʻau: FDA faʻamaonia Chenodeoxycholic Acid CDCA mo PBC, faʻaleleia faʻamaoniga o galuega ate (ALT / AST faʻaititia e sili atu i le 50%);
Togafitiga tu'ufa'atasi: tu'ufa'atasiChenodeoxycholic Acidfaʻatasi ai ma le ursodeoxycholic acid (UDCA), e faʻaleleia le aoga ile 30%.
3. Fa'atonutonuina o Fa'ama'i Metabolic
Fa'aitiitia le ga'o o le toto: fa'aitiitia le cholesterol atoa (TC) ma le lipoprotein maualalo (LDL);
Anti-maʻisuka: faʻaleleia le faʻaogaina o le inisalini, faʻataʻitaʻiga manu e faʻaalia ai e pa'ū le suka toto i le 20%
4. Fa'atonuga Fa'aleaga ma le Puipuia
Taofi le ala NF-κB ma faʻaitiitia le tuʻuina atu o mea faʻamaʻi (TNF-α, IL-6);
O suʻesuʻega faʻapitoa ua faʻaalia ai o le faʻaleleia atili o le ate fibrosis i tagata mamaʻi e le o le ava malosi o le ate (NAFLD) e sili atu i le 60%.
● O a Talosaga OChenodeoxycholic Acid ?
1. Fa'afomai
Togafitiga ma'a: CDCA papa'a (250mg/tablet), fua ole aso 10-15mg/kg;
Togafitiga a le PBC: sauniuniga faʻatasi ma le UDCA (e pei o Ursofalk®), faʻatauga faʻaletausaga o le lalolagi e sili atu i le US $ 500 miliona;
Su'esu'ega fa'ama'i: fa'alavelaveina le fa'atuputeleina o sela o le kanesa o le ate e ala i le fa'atonutonuina o FXR receptors, ulufale atu i le Vaega II fa'ata'ita'iga falema'i.
2. Mea'ai ma Mea'ai Fa'alesoifua maloloina
Fualaau puipuia o le ate: fua fa'afefiloi (CDCA + silymarin), fa'aitiitia le fa'aleagaina o le ate;
Lipid-fa'alalo capsules: fa'atasi ma le fa'afefete mumu fa'afefete araisa e fa'atonutonu ai le gaioiina o le toto.
3. Tausia Manu ma Fa'ato'aga
Fafaga faaopoopo: faʻaleleia lafumanu ma moa moa gaʻo metabolism, faʻaitiitia le gaʻo o le manava;
Soifua Maloloina o i'a: fa'aopoopo 0.1%chenodeoxycholic acide faʻaleleia ai le faʻamaʻi o le carp ma faʻateleina le ola i le 15%.
4. Mea teuteu ma le tausiga o le tagata lava ia
Anti-inflammatory essence: 0.5% -1% faʻaopoopoga, faʻaleleia le paʻu ma le paʻu o le paʻu;
Tausiga o le ulu: faʻalavelave Malassezia ma faʻaitiitia le faʻatupuina o dandruff.
Mai le su'eina o le talo masani i le microbial synthesis, o le chenodeoxycholic acid o loʻo i ai se suiga mai se "mea faʻalenatura" i se "vailaau saʻo". Faatasi ai ma le faʻalolotoina o suʻesuʻega i faʻamaʻi faʻamaʻi ma faʻamaʻi pipisi, e mafai ona avea le CDCA ma mea autu autu mo togafitiga faʻamaʻi ate, meaʻai aoga ma biomaterials, e taʻitaʻia ai se galu fou o le 100 piliona pisinisi soifua maloloina.
● NEWGREEN SapalaiChenodeoxycholic AcidO le pauta
Taimi meli: Iuni-11-2025
