Zinc Pyrithione (ZPT): Fungicide ya Multi-Domain

 

●Niki Zinc Pyrithione?

Zinc pyrithione (ZPT) ni uruganda rwa zinc rugizwe na molekuline ya C₁₀H₈N₂O₂S₂Zn (uburemere bwa molekile 317.7). Izina ryayo rikomoka ku miterere karemano y’ibiti bya Annonaceae Polyalthia nemoralis, ariko inganda zigezweho zafashe imiti y’imiti kugirango ikore. Mu 2024, Ubushinwa bwatangiwe ipatanti bwacishije mu cyuho, kandi acide ya crotonic yanduye yagenzurwaga munsi ya 16ppm binyuze muri methanol-acetone yo mu rwego rwa kristu, hanyuma ubuvuzi bwa farumasi bwiyongera bugera kuri 99.5%.

 

Imiterere yumubiri na chimique:

Kugaragara no gukemuka: ifu yera ya hristaline yumuhondo yoroheje gato, hafi yo kudashonga mumazi (<0.1g / 100mL), gushonga gake muri Ethanol, gukomera muri polyethylene glycol irashobora kugera kuri 2000mg / kg;

Inenge zihamye: zumva urumuri na okiside, byangirika byoroshye nurumuri ultraviolet, ipaki yijimye isabwa; kunanirwa gutandukana kuri pH <4.5 cyangwa> 9.5, pH nziza ni 4.5-9.5;

Ubushuhe bwangirika bwumuriro: buhamye kumasaha 120 kuri 100 but, ariko burangirika vuba hejuru ya 240 ℃;

Kudahuza: imvura igwa hamwe na cactic surfactants, chelates na discolors hamwe na ion / fer y'umuringa (niyo 1ppm irashobora gutuma ibicuruzwa bihinduka umuhondo).

 

●NikiInyunguBya Zinc Pyrithione ?

ZPT igera kuri sterisile yagutse (ikora neza kurwanya ubwoko 32 bwa mikorobe) ikoresheje uburyo bwihariye bwo guhanahana ion, cyane cyane kuri Malassezia, nyirabayazana ya dandruff, hamwe na MIC iri munsi ya 8ppm:

 

1. Ion Gradient Kurimbuka

Mubidukikije bya acide, H⁺ yinjiza muri bagiteri na K⁺ isohoka, naho mubidukikije bwa alkaline, Na⁺ / Mg²⁺ irasimburwa, isenya mikorobe yo gutwara intungamubiri;

 

2. Kumeneka kwa selile

Kwinjiza muri fosifolipide bilayeri, kongera ubwonko bwa membrane no gutera ibintu biva mu nda;

 

3. Kubuza ibikorwa bya Enzyme

Guhagarika imiyoboro ya transport ya electron no guhagarika imisemburo yingenzi yingufu za metabolisme (nka synthase ya ATP).

 

Kugenzura kwa Clinical: Nyuma yo gukoresha shampoo irimo 1.5%zincpyrithionemu byumweru 4, dandruff igabanukaho 90%, naho igipimo cyo kugaruka kwa dermatite ya seborheque kigabanukaho 60%.

 

 

●NikiGusabaOf Zinc Pyrithione?

1. Imiti ya buri munsi:

Irashobora gukoreshwa muri 70% ya anti-dandruff shampoo, hiyongereyeho 0.3% -2%;

 

Ibicuruzwa bimwe byo kwisiga birashobora kugabanya ikoreshwa rya zinc pyrithione kandi bigomba gushyirwaho ikimenyetso "kwoza nyuma yo gukoresha". Urashobora gukoresha ubundi buryo bwibicuruzwa piroctone ethanolamine (OCT).

 

2. Kurwanya ruswa mu nganda:

Impinduramatwara yo kurwanya ibibi: yongewemo na oxyde ya cuprous kugirango ibuze kwizirika kuri barnacle no kugabanya ikoreshwa rya peteroli mu bwato 12%;

 

3. Ubuhinzi n'ibikoresho:

Kurinda imbuto: 0,5% yo gutwikira birinda indwara kandi byongera umuvuduko wa 18%;

 

Fibre Antibacterial fibre: yometseho polyester ifite igipimo cya antibacterial ya> 99%.

 

4. Kwagura ubuvuzi:

Ibizamini bitatu-bitera ibibi (nta kanseri / teratogenicity / mutagenicity), ikoreshwa kuri acne gel hamwe na antibacterial coating ibikoresho byubuvuzi.

 

●Inama:

Nubwo uburozi bukabije bwo mu kanwaof zinc pyrithioneni hasi (LD₅₀> 1000mg / kg mu mbeba), kuburira kwa kliniki mumyaka yashize:

 

Uburozi bwuruhu: guhura igihe kirekire bitera dermatite ya allergique, kandi guhuza amaso birashobora gutera conjunctivitis;

 

Kurwanya burundu:

Skin Uruhu rwacitse (permeability yiyongera inshuro 3, bigatuma habaho sisitemu);

Women Abagore n'abana batwite (inzitizi y'amaraso-ubwonko bwinjira);

 

Imikoreshereze yibiyobyabwenge: Irinde gukoresha hamwe na EDTA (chelating zinc ion igabanya ingaruka zibiyobyabwenge).

 

●NEWGREEN Tanga ubuziranengeZinc PyrithioneIfu