● NikiThiamine Hydrochloride ?
Thiamine hydrochloride ni hydrochloride ya vitamine B₁, hamwe na formula ya chimique C₁₂H₁₇ClN₄OS · HCl, uburemere bwa molekile 337.27, na CAS nimero 67-03-8. Ni ifu yera yumuhondo-yera-kristaline ifu yumuceri wumuceri uhumura neza nuburyohe bukaze. Biroroshye gukuramo ubuhehere muburyo bwumutse (burashobora gukuramo ubuhehere bwa 4% mugihe uhuye numwuka). Ibyingenzi byumubiri nubumashini birimo:
Gukemura:Gushonga cyane mumazi (1g / mL), gushonga gato muri Ethanol na glycerol, no kudashonga mumashanyarazi kama nka ether na benzene.
Igihagararo:Ihamye mubidukikije bya acide (pH 2-4) kandi irashobora kwihanganira ubushyuhe bwo hejuru bwa 140 ° C; ariko ibora vuba mubisubizo bidafite aho bibogamiye cyangwa alkaline kandi ntibishobora gukoreshwa nimirasire ya ultraviolet cyangwa imiti ya redox.
Ibiranga gutahura:Irakora hamwe na ferric cyanide kugirango itange ibintu byubururu bwa fluorescent "thiochrome", biba ishingiro ryisesengura ryinshi38.
Gahunda yo kwitegura kwisi kwisi yose ni synthesis ya chimique, ikoresha acrylonitrile cyangwa β-ethoxyethyl propionate nkibikoresho fatizo kandi ikorwa hifashishijwe kondegene, kuzunguruka, gusimbuza izindi ntambwe, hamwe nubuziranenge burenga 99%.
●Ni izihe nyunguThiamine Hydrochloride ?
Thiamine hydrochloride ihindurwa muburyo bukora bwa thiamine pyrophosphate (TPP) mumubiri wumuntu, kandi ikina imirimo myinshi yumubiri:
1. Ingufu za metabolism yibanze:nka coenzyme ya α-ketoacid decarboxylase, igira uruhare rutaziguye mugikorwa cyo guhindura glucose kuri ATP. Iyo ibuze, biganisha ku kwirundanya kwa pyruvate, bigatera aside ya lactique na crise yingufu.
2. Kurinda sisitemu y'imitsi:Kugumana imiyoboro isanzwe yimitsi. Kubura bikabije bitera beriberi, hamwe nibimenyetso bisanzwe birimo neurite ya periferique, atrophy yimitsi, no kunanirwa k'umutima. Amateka, yateje icyorezo kinini muri Aziya, gihitana abantu ibihumbi magana buri mwaka.
3. Agaciro k’ubushakashatsi kavutse:
Kurinda Myocardial:10μM kwibandaho birashobora kurwanya acetaldehyde iterwa na myocardial selile yangiza, ikabuza gukora caspase-3, kandi ikagabanya poroteyine ya karubone.
Kurwanya neurodegeneration:Mu bushakashatsi bw’inyamaswa, kubura bishobora gutuma habaho kwirundanya bidasanzwe kwa poroteyine β-amyloide mu bwonko, ibyo bikaba bifitanye isano n’indwara y’indwara ya Alzheimer.
Amatsinda afite ibyago byinshi byo kubura harimo:kurya igihe kirekire umuceri wera n'ifu inoze, abanywi b'inzoga (Ethanol ibuza kwinjiza thiamine), abagore batwite, n'abarwayi barwaye impiswi idakira.
●Ni ubuhe buryo bukoreshwaThiamine Hydrochloride ?
1. Inganda zibiribwa (umugabane munini):
Kongera intungamubiri:wongeyeho ku binyampeke (3-5mg / kg), ibiryo by'abana (4-8mg / kg), n'ibinyobwa by'amata (1-2mg / kg) kugira ngo bibuze gutakaza intungamubiri ziterwa no gutunganya neza.
Ibibazo bya tekiniki:Kuberako byoroshye kubora mubidukikije bya alkaline, ibikomoka kuri nitrati ya thiamine akenshi bikoreshwa nkibisimbuza ibiryo bitetse.
2. Ubuvuzi:
Porogaramu zo kuvura:inshinge zikoreshwa mukuvura byihutirwa kwa beriberi (kunanirwa k'umutima / kunanirwa k'umutima), kandi imyiteguro yo mu kanwa ikoreshwa nk'ubuvuzi bufasha neurite no kutarya.
Ubuvuzi bukomatanya:ifatanije na magnesium agent kugirango itezimbere imikorere ya Wernicke encephalopathie no kugabanya igipimo cyisubiramo.
3. Ubuhinzi n’ibinyabuzima:
Indwara ziterwa no kurwanya indwara:50mM ivura umuceri, imyumbati, nibindi, ikora genes ziterwa na virusi (PR gen), kandi ikongerera imbaraga ibihumyo na virusi.
Kugaburira ibiryo:Kunoza imikorere ya metabolisme isukari mu bworozi n’inkoko, cyane cyane ahantu h’ubushyuhe bukabije (kongera ibyifuzo byo gusohora ibyuya).
● NEWGREEN Itanga ubuziranengeThiamine HydrochlorideIfu
Igihe cyo kohereza: Jun-30-2025
