• NikiTUDCA ?
Imirasire y'izuba niyo mpamvu nyamukuru itera umusaruro wa melanin. Imirasire ya ultraviolet mu zuba ryangiza aside deoxyribonucleic, cyangwa ADN, mu ngirabuzimafatizo. ADN yangiritse irashobora gukurura kwangirika no kwimura amakuru yimiterere, ndetse ikanatera ihinduka ryimiterere ya gene mbi, cyangwa gutakaza genes suppressor genes, bigatuma habaho ibibyimba.
Nyamara, izuba ryinshi ntabwo "riteye ubwoba", kandi ibi byose ni "inguzanyo" kuri melanin. Mubyukuri, mugihe gikomeye, melanin izarekurwa, ikoreshe neza ingufu z'imirasire ya ultraviolet, irinde ADN kwangirika, bityo bigabanye kwangirika kwatewe nimirasire ya ultraviolet kumubiri wumuntu. Nubwo melanin irinda umubiri wumuntu kwangirika kwa ultraviolet, irashobora kandi gutuma uruhu rwacu rwijimye kandi rugatera ibibara. Kubwibyo, guhagarika umusaruro wa melanin nuburyo bwingenzi bwo kwera uruhu mubikorwa byubwiza.
Ni izihe nyungu zaTUDCAmu kongera siporo?
Inyungu nyamukuru ya TUDCA itezimbere ubuzima bwumwijima nimikorere. Ubushakashatsi butanga ibisubizo bitangaje byo kugabanuka kwimisemburo yumwijima nyuma yinyongera ya TUDCA. Umusemburo mwinshi wumwijima werekana ubuzima bwumwijima nubushobozi buke, mugihe imisemburo mike yumwijima yerekana ubuzima bwumwijima nibikorwa. Kwiyongera hamwe na TUDCA byagaragaje kugabanuka cyane mumisemburo yingenzi yumwijima, byerekana ubuzima bwumwijima.
Iterambere ryubuzima bwumwijima nicyo gituma TUDCA igira ingaruka zikomeye kubakoresha ibintu bya anabolike, cyane cyane ibintu byo mu kanwa. Ibi bintu birashobora kugira ingaruka zikomeye kubuzima bwumwijima no mumikorere yacu, kandi gufata ibyongeweho byunganira buri gihe birasabwa usibye kwipimisha amaraso buri gihe kugirango ukurikirane ubuzima. TUDCA ifatwa nkimwe mubyiza byubuzima bwumwijima biboneka uyumunsi.
TUDCAishoboye kurinda mitochondriya ibice bigize selile bisanzwe bitera iyi mvururu, bityo bikarinda apoptose. Irabikora mukubuza molekile yitwa Bax kujyanwa muri mitochondria. Iyo Bax yimuwe muri cytosol ikajya muri mitochondriya, ihungabanya imiterere ya mito-iyambere, itangiza uruhererekane rwibintu. Muguhagarika Bax hamwe na TUDCA, bizarinda synthesis ya selile selile, hanyuma ikabuza kurekura cytochrome c, nayo ikabuza mitochondriya gukora caspase. TUDCA irinda urupfu rw'uturemangingo ikingira ingirabuzimafatizo ya mitochondrial selile.
TUDCA irinda urupfu rwingirabuzimafatizo ikingira ingirabuzimafatizo ya mitochondrial selile ibintu byangiza. Iyi nzira nigisubizo cyumubiri niyo mpamvu ubushakashatsi burimo kureba inyungu zo kuzuza TUDCA kubantu bafite ibibazo byubwonko bw’imitsi nka Parkinson, Huntington, Alzheimer's, na ALS. Ibisubizo byubu bushakashatsi nibitekerezo byambere birashimishije cyane. TUDCA irashobora kugira ingaruka zingirakamaro ku ndwara nyinshi zikomeye.
Ubushakashatsi bwerekanye kandi ko TUDCA itezimbere insuline mu mitsi no mu mwijima, kandi ikagira ingaruka nziza ku buzima bwa tiroyide.
• Ni bangaheTUDCAbigomba gufatwa?
Ingano zitandukanye zakozweho ubushakashatsi ku nyungu za TUDCA. Guhera kuri mg 10-13 mg ziyongera kuri TUDCA kumunsi, abarwayi bafite indwara zumwijima zidakira bagabanutse cyane mumisemburo yumwijima mumezi 3. Dose igera kuri mg 1,750 kumunsi byagaragaye ko ari ingirakamaro ku ndwara zifata umwijima no kunoza imitsi n’umwijima insuline. Inyamaswa zakozwe zerekanye ibipimo bigera kuri 4000 mg (bihwanye n'abantu) byagize ingaruka nziza kuri neuroprotection kuva kubura imyaka.
Nubwo iyi dosiye ikabije, hagati ya mg 500 na mg 1.500 kumunsi bisa nkigipimo cyiza cyo gutanga ingaruka za TUDCA. Ibyinshi byongeweho bigaragara ko byateguwe birimo 100 - 250 mg ya TUDCA kuri buri serivisi, gufatwa inshuro nyinshi kumunsi. Kimwe na byinshi muribi bikoresho, ubushakashatsi burakenewe kugirango ubone imibare yihariye.
• Ni ryariTUDCAgufatwa?
TUDCA irashobora gufatwa igihe icyo aricyo cyose cyumunsi, kandi nibyiza gufatwa nibiryo kugirango bifashe kwinjizwa. Nkuko byavuzwe haruguru, inyongera nyinshi zifatwa kuri 100 - 250 mg kuri buri serivisi. Birasabwa gukwirakwiza dosiye ya TUDCA umunsi wose, kuyifata inshuro 2, 3, 4 cyangwa inshuro 5 kumunsi.
• Bifata igihe kingana iki kugirango TUDCA ikore?
TUDCA ntabwo ikora ijoro ryose. Ubushakashatsi bwerekanye ingaruka zitandukanye za TUDCA nyuma y amezi 1, 2, 3 cyangwa se amezi 6 yinyongera. Duhereye ku bushakashatsi buboneka, ntawabura kuvuga ko byibuze iminsi 30 (ukwezi 1) yinyongera isabwa kugirango ubone iterambere ninyungu. Ariko, gukomeza kandi igihe kirekire gukoresha bizatanga inyungu nini zo kuzuza TUDCA.
Igihe cyo kohereza: Ukuboza-06-2024
