Synephrine Hydrochloride: "Ikintu gisanzwe cyamaraso-Yongera imbaraga" yakuwe muri Citrus Aurantium

●Niki Synephrine Hydrochloride?

Synephrine HCl nuburyo bwa hydrochloride ya synephrine, hamwe na formula ya chimique C₉H₁₃NO₂ · HCl (uburemere bwa molekile 203.67). Synephrine yayo isanzwe ikomoka cyane cyane ku mbuto zumye (citrus aurantium) z'igihingwa cya Rutaceae. Citrus aurantium ikwirakwizwa cyane mu ntara z’uruzi rwa Yangtze mu Bushinwa, nka Sichuan, Jiangxi, na Zhejiang. Ibigize synephrine mu mbuto zayo zikiri nto birashobora kugera kuri 30% byuburemere bwumye. Gukuramo gakondo bishingiye ku gukuramo inzoga (75% gukuramo Ethanol inshuro 3, gutanga umusaruro 85%), ariko mu myaka yashize, guhanga udushya byibanze ku cyatsi kandi cyiza:

Enzymatique hydrolysis-membrane itandukanya: ifumbire ya pectinase hydrolyzes pectine kuri 40 ° C na pH 4.5, ifatanije na 0.22μm inorganic ceramic membrane filtration, igipimo cyo gukuraho umwanda kigera kuri 91%, kandi ubuziranenge bwiyongera kugera kuri 95%;

Ikoranabuhanga ryo gusimbuza ibihumyo: Ishuri ry’Ubuhinzi ry’Ubushinwa ryashyizeho uburyo bwa fermentation ya Ganoderma lucidum yo gukora ibintu bisa na synephrine, bigabanya ibiciro 30% kandi bigabanya umuvuduko w’ubucukuzi bw’amabuye y'agaciro mu buryo butemewe.

●NikiInyunguBya Synephrine Hydrochloride ?

Synephrine hydrochloride, nka agonisti ya adrenaline α / β yakira, ivugurura agaciro kivuriro binyuze mubikorwa byinshi:

1. Ibihe byihutirwa byumutima

Ibyishimo α byakira kugirango bigabanye imiyoboro yamaraso no kongera umuvuduko wamaraso, bikoreshwa muri anesthesia, hypotension, gutabara, kandi umuvuduko wo gutangira wihuta 40% kuruta imiti gakondo;

Gukora β reseptors kugirango yongere myocardial kwandura no kunoza imikorere yo kuvoma abarwayi bafite ikibazo cyumutima.

2. Gutabara Sisitemu Yubuhumekero

Synephrinehydrochlorideskwaguka cyane imitsi yoroshye ya bronchial, irwanya rwose spasime iterwa na histamine, kandi wongere FEV1 yerekana imikorere yibihaha kubarwayi barwaye asima ya bronchial 25%.

3. Amabwiriza ya Metabolic

Impinduramatwara ya okiside yibinure: Kangura igipimo cya metabolike ya tissue adipose yumukara 50%, kandi gufata buri munsi mg 20 bishobora kugabanya ibinure byumubiri 3,5%;

Ubushobozi bwa Neuroprotective: Guhindura byanze bikunze acetylcholinesterase, kunoza amanota yimikorere yubwenge bwabarwayi ba démée 30%, kandi igihe cyo gukora nikubye kabiri imiti isanzwe.

Ubuvumbuzi bwambukiranya imipaka: Ubushakashatsi bwakozwe na kaminuza y’amajyepfo y’iburengerazuba bwerekanye ku nshuro ya mbere umurimo wo kubungabunga imbuto n'imboga - 0.1mmol / Lsynephrine hydrochloridekuvura birashobora kubuza ibikorwa bya okiside ya polifenol mu gishishwa cya litchi, gutinda kwirabura muguhindura metabolisme ya membrane lipide, kandi ikongerera igihe cyiminsi 14.

●NikiGusabaOf Synephrine Hydrochloride?

1. Isoko ryiganje mu murima wa farumasi

Imyiteguro yubufasha bwambere: inshinge na tableti bikoreshwa mukubaga hypotension no gutungurwa.

Gucunga indwara zidakira: zifatanije na aminophylline mu kuvura asima ya bronchial, igitero gikaze kigabanukaho 60%.

Imiti igabanya ibiro: nkibisanzwe bisanzwe bya ephedrine, irashobora gukoreshwa nkinyongera ya siporo.

2. Guhanga udushya mu kubungabunga ubuhinzi

Lychee browning inhibitor: nyuma ya lychee isaruwe ikavurwa hamwesynephrine hydrochloride, igiciro cyose ni 1/3 gusa cyurunigi rukonje.

Citrus antiseptic coating: nanoemulsion yongewemo na chitosan, igipimo cya antibacterial ni> 99%, kandi igihe cyo kubika ubushyuhe bwicyumba cyongerewe iminsi 21.

3. Kwagura ibicuruzwa byumuguzi bikora

Ibinyobwa bitera imbaraga: “Synephrine + taurine” ibinyobwa bikora birashobora guteza imbere kwihanganira siporo

Ibiryo byubuzima bwiza: imyiteguro ya capsule yibanda kuri acetylcholinesterase kugirango ubashe kunanirwa kwibuka.

Icyatsi gishya gitanga ubuziranenge Synephrine Hydrochloride Ifu