Minoxidil: Gushyira mu bikorwa "Ubuvuzi bukura bwimisatsi"

●Niki Minoxidil?

Mu nkuru itunguranye yerekana amateka yubuvuzi, minoxidil irashobora gufatwa nkimwe mubintu byatsinze "kuvumbura impanuka". Iyo yatunganijwe nk'imiti igabanya ubukana mu myaka ya za 1960, ingaruka mbi ya hypertrichose yatewe na yo yabaye impinduka mu kuvura umusatsi. Nyuma yimyaka hafi 60 yiterambere, uru ruganda rwakuyemo dosiye nyinshi nkibisubizo, ifuro, na geles. Igipimo cyiza cya 5% minoxidil mukuvura telogene effluvium irenga 80%, ibyo byongeye kwemeza ubushobozi bwayo bwo kwerekana.

Izina ryimiti ya minoxidil ni 6- (1-piperidinyl) -2,4-pyrimidinediamine-3-oxyde, hamwe na formulike ya molekuline ya C₉H₁₅N₅O, aho yashonga ya 272-274 ℃, ingingo ya 351.7 ℃, ubucucike bwa 1.1651 g / cm³, kandi byoroshye gushonga mumazi, hamwe na glyol byoroshye.

● NikiInyunguBya Minoxidil ?

Hashingiwe ku bushakashatsi bwakozwe na molekuline, minoxidil yerekana ingaruka zishingiye ku binyabuzima:

1. Imikorere y'amaraso

Ikora imiyoboro ya potasiyumu ya ATP (KATP), yoroshya imitsi yoroshye yimitsi, kandi yongera umuvuduko wamaraso mumutwe 40% -60%.

Itezimbere imvugo ya VEGF, yongera ubwinshi bwimitsi yamaraso inshuro 2,3, kandi itezimbere intungamubiri zumusatsi.

2. Amabwiriza yimisatsi yumuzingi

Gabanya icyiciro cyo kuruhuka (kuva muminsi 100 kugeza kuminsi 40) hanyuma wongere icyiciro cyo gukura kugeza kumunsi urenze 200.

MinoxidilIrashobora gukora inzira ya Wnt / β-catenin, kandi ikongerera igipimo cyimisemburo ya papilla yimisatsi 75%.

3. Gutezimbere Ibidukikije bya Microen

Irabuza ibikorwa 5α-reductase, igabanya ubukana bwa DHT kuri 38%, kandi igabanya alopecia ya androgene.

Igenga ibintu bitera nka IL-6 na TNF-α, kandi igabanya amanota yo gutwika umutwe 52%.

● NikiGusabaOf Minoxidil?

Minoxidil irenga imipaka yerekana ibimenyetso gakondo:

1. Ubuvuzi bwimisatsi

Alopecia ya Androgeneque: 5% igisubizo kivura AGA yumugabo, kandi igipimo cyimisatsi cyiyongera 47% mumezi 12.

Alopecia areata: Ubushakashatsi bwakozwe n’Abayapani mu 2025 bwerekanye ko imikorere ya JAK inhibitor ikomatanyije yavuye kuri 35% igera kuri 68% hamwe n’umuti umwe.

2. Kuvugurura uruhu

Ibisebe bya diyabete: Gushyira mu bikorwa byihutisha gukira ibikomere kandi bigabanya igihe cyo gukira 30%.

Gusana inkovu: Kubuza imvugo ya TGF-β1 kandi bigabanya ubukana bwinkovu 42%.

3. Ubuhinzi no Kurengera Ibidukikije

Amabwiriza yo gukura kw'ibihingwa: 0.1ppm igisubizo kivura umuceri, kandi umubare w'abahinzi wiyongera 18%.

Gutunganya ubutaka: Imikorere ya adsorption ya cadmium yicyuma kiremereye igera kuri 89%, ikoreshwa mugusana ibidukikije mumabuye y'agaciro.

● KwirindaByaMinoxidil Gukoresha Igihe kirekire

Ibipimo byo gukurikirana: Kugenzura buri gihe umuvuduko wamaraso nigipimo cyumutima, cyane cyane kubafite indwara zifata umutima;

Amatsinda yanduye: Birabujijwe abagore batwite, abagore bonsa, naba allergique kuri propylene glycol;

Guhitamo dosiye: 5% kwibanda kubagabo, naho 2% birashobora gutoranywa kubagore kugirango bagabanye ingaruka;

Kuvura hamwe: Gutakaza umusatsi bikabije birashobora guhuzwa na finasteride (kubagabo) cyangwa kuvura ingufu nke za laser.

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Icyatsi gishya gitanga ubuziranenge MinoxidilIfu