Ivermectin: Umuti mushya wa Antiparasitike

●Niki Ivermectin?

Ivermectin ni antibiyotike ya macrolide ya kimwe cya kabiri ikomoka kuri fermentation no kweza Streptomyces avermitilis. Irimo ibice bibiri: B1a (≥80%) na B1b (≤20%). Inzira ya molekile yayo ni C48H74O14, uburemere bwa molekile ni 875.09, na CAS nimero 70288-86-7.

Mu mwaka wa 2015, abavumbuye William C. Campbell na Satoshi Omura begukanye igihembo cyitiriwe Nobel muri Physiology cyangwa Medicine kubera uruhare runini bagize mu kurwanya ubuhumyi bw'inzuzi n'inzovu.

Imiterere yumubiri nubumara

Ibyiza: ifu yera cyangwa yoroheje yumuhondo wa kristaline, impumuro nziza;

Gukemura: byoroshye gushonga mumashanyarazi nka methanol, Ethanol, acetone, kandi hafi yo kudashonga mumazi (solubile ni 4μg / mL);

Igihagararo: ntabwo byoroshye kubora mubushyuhe bwicyumba, ariko biroroshye kumanuka mumucyo, bigomba kubikwa ahantu hafunze kandi hatarimo urumuri, kandi kubika igihe kirekire bisaba ubushyuhe buke bwa 2-8 ℃;

●NikiInyunguBya Ivermectin ?

Ivermectin yibasira sisitemu ya parasite nervice ikoresheje inzira ebyiri:

1. Guteza imbere irekurwa rya neurotransmitter γ-aminobutyric aside (GABA) kugirango ibuze kwanduza ibimenyetso;

2. Fungura imiyoboro ya glutamate ya chloride ion kugirango itere hyperpolarisation no kumugara imitsi ya parasite.

Ubushobozi bwayo mukwica nematode (nk'inzoka zangiza hamwe na hookworms) hamwe na arthropods (nka mite, amatiku, na lice) biri hejuru ya 94% -100%, ariko ntibishobora kurwanya inzoka zangiza.

●NikiGusabaOf Ivermectin?

1. Umwanya wamatungo (gutandukanya dosiye neza)

Inka / intama: 0.2mg / kg (inshinge zo mu nda cyangwa ubuyobozi bwo mu kanwa), irashobora gukuraho nematode yo mu gifu, filariya y'ibihaha hamwe n'ibisebe hejuru yumubiri;

Ingurube: 0.3mg / kg (inshinge zo mu nda), igipimo cyo kurwanya inzoka n’ibisebe hafi 100%;

Imbwa ninjangwe: 6-12μg / kg kugirango wirinde kandi uvure ibyonnyi byumutima, 200μg / kg kugirango wice amatwi;

Inkoko: 200-300μg / kg (ubuyobozi bwo mu kanwa) bugira ingaruka nziza kurwanya inzoka zinkoko hamwe na mite.

2. Kuvura abantu

Ivermectinni ibiyobyabwenge shingiro byumuryango w’ubuzima ku isi, bikoreshwa cyane cyane:

Onchocerciasis (ubuhumyi bwinzuzi): 0.15-0.2mg / kg ikinini kimwe, igipimo cya microfilariae kirenga 90%;

Stregostrongyloidiasis: 0.2mg / kg ikinini kimwe;

Indwara ya Ascaris na whipworm: 0.05-0.4mg / kg kuvura igihe gito.

3. Imiti yica udukoko twangiza ubuhinzi

Nka bio-soko yica udukoko twica udukoko, ikoreshwa mugucunga mite yibihingwa, inyenzi za diyama, abacukura amababi, nibindi, kandi bifite ibimenyetso bisigaye.

●Umutekano n'imbogamizi

Ivermectinni umutekano muke ku nyamaswa z’inyamabere (biragoye kwinjira mu nzitizi y’amaraso n'ubwonko), ariko haracyariho kubuza:

Ingaruka mbi: Rimwe na rimwe kubabara umutwe, guhubuka, kwiyongera kwimisemburo yumwijima, hamwe na dosiye nyinshi birashobora gutera ataxia;

Ubwoko butandukanye bwo kumva: Imbwa z'abungeri nandi moko yimbwa zirashobora kugira neurotoxicity ikomeye;

Uburozi bw'imyororokere: Ubushakashatsi bw’inyamaswa bwerekana ko dosiye nyinshi zifite ibyago byo gutera teratogenicite (palate palate, deformity claw).

Ikibazo cyisi yose yo kurwanya parasite kiragenda gikomera. Ubushakashatsi bwakozwe mu 2024 bwerekanye ko guhuza ivermectin na albendazole bishobora kunoza imikorere yo kurwanya filariasis. Ibigo byinshi bikorerwamo ibya farumasi kwisi biteza imbere kuzamura ikoranabuhanga ryibikoresho fatizo, kandi ubuziranenge bugeze kuri 99%.

● NEWGREEN Itanga ubuziranengeIvermectinIfu