Glutathione: Antioxydants ikomeye

●NikiGlutathione ?

Glutathione (GSH) ni uruganda rwa tripeptide (formula ya molekile C.₁₀H₁₇N₃O₆S) byakozwe na acide glutamic, cysteine?na glycine ihujwe naγ-amide inkwano. Intangiriro ikora nitsinda rya sulfhydryl (-SH) kuri sisitemu, itanga imbaraga zo kugabanya imbaraga.

Ubwoko bubiri bwingenzi bwa physiologique ya glutathione:

1. ikuraho byimazeyo radicals yubuntu kandi ikingira selile kwangirika kwa okiside.

2. Oxidized glutathione (GSSG): ikorwa na okiside ya molekile ebyiri za GSH (GSSG), hamwe nibikorwa bidafite umubiri; munsi ya catalizike ya redutase ya glutathione, biterwa na NADPH kugabanuka kuri GSH kugirango ikomeze kuringaniza redox selile.

●Ni izihe nyungu zaGlutathione ?

1. Imikorere yibanze ya physiologiya

Kwangiza no kurinda umwijima:

Glutathione irashobora cshyira ibyuma biremereye (gurş, mercure), uburozi bwibiyobyabwenge (nka cisplatine) na metabolite ya alcool. Gutera imitsi ya 1800mg / kumunsi birashobora kunoza imikorere yumwijima, kandi igipimo cyiza cyo kuvura indwara yumwijima yinzoga kirenga 85%.

Umufasha wo kurwanya ibibyimba:

Glutathione irashobora rkwigisha chimiotherapie nephrotoxicity, kongera ibikorwa byingirabuzimafatizo zica (selile NK) inshuro 2, kandi bikabuza guhagarika umutima kanseri yibibyimba.

Kurinda imitsi n’amaso:

Glutathione rgukuraho ibimenyetso hakiri kare byindwara ya Parkinson no kugabanya dopamine neurotoxicity; Gukoresha hafi yibitonyanga byamaso birashobora gusana ibisebe bya corneal kandi bikabuza iterambere rya cataracte.

2. Ubuzima nubwiza bukoreshwa

Kurwanya gusaza gukingira indwara: Koresha poroteyine ya Sirtuins no gutinda kugabanya telomere; kuzamura imikorere ya lymphocyte no kugabanya kurekura ibintu bitera umuriro;

Kwera no gukuraho ibibanza: Kubuza ibikorwa bya tyrosinase no kugabanya umusaruro wa melanin. Ivuriro ryerekanwe kunoza uruhu rworoshye no kugabanya ubujyakuzimu bwa 40%.

Ni ubuhe buryo bukoreshwasBya Glutathione ?

1. Ubuvuzi

Gutera inshinge: bikoreshwa mukurinda chimiotherapie (1.5g / m² dose), uburozi bukabije bwambere, kandi bigomba kubikwa kure yumucyo;

Gutegura umunwa: gukoresha igihe kirekire (200-500mg / isaha, amezi arenga 6) kugirango wongere umubiri wa GSH kandi ufashe kuvura indwara zumwijima zidakira.

2. Ibiryo bikora

Antioxidant inyongera: vitamine C ivanze (vitamine C 500mg kumunsi irashobora kongera urugero rwa GSH 47%) cyangwa seleniyumu kugirango yongere ubudahangarwa;

Hangover n'ibiryo birinda umwijima: byongeyehoglutathionekubinyobwa bikora kugirango byihutishe metabolism alcool no kugabanya kwangirika kwumwijima.

3. Guhanga udushya two kwisiga

Whitening essence: ikoreshwa cyane mumasoko ya Aziya kugirango ibuze melanin, ihujwe na tekinoroji ya microneedle kugirango uruhu rwinjire;

Imiti irwanya gusaza: liposome ikubiyemo GSH irwanya kwangirika kwa ultraviolet kandi igabanya erythma yo gufotora 31% -46%.

4. Gukoresha Ikoranabuhanga Rishya

Gutanga imiti igamije: Nanogels yitabira GSH irashobora kurekura byimazeyo imiti ya chimiotherapie (nka doxorubicin) aho ikibyimba, igatezimbere kandi ikagabanya ingaruka mbi;

Kurengera ibidukikije n’ubuhinzi: Gutezimbere ibikoresho bishobora kwangirika no gushakisha inyongeramusaruro zongerera ubworozi n’ubudahangarwa bw’inkoko.

Kuva kuri patenti yo gukuramo umusemburo kugeza umusaruro mwinshi wa toni ibihumbi muri biologiya yubukorikori muri iki gihe, inzira yinganda za glutathione yemeje ko “umurinzi w’akagari” ahinduka “moteri y’ikoranabuhanga”. Mu bihe biri imbere, hamwe no kurangiza kugenzura kwa muganga ibimenyetso bishya bya neuroprotection no kurwanya gusaza, iyi molekile itwara ubuzima izakomeza gutanga imbaraga za siyanse ku buzima bw’abantu no kuramba. 

●Isoko RishyaGlutathione Ifu