● NikiSclareol ?
Sclareol, izina ryimiti (1R, 2R, 8aS) -decahydro-1- (3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, formula ya molekuline C₂₀H₃₆O₂, uburemere bwa molekile 308.29-308.50, CAS nimero 515-03-7. Ni igare rya diterpenoid yamagare, hamwe nifu yifu ya kristaline yera, gushonga 95-105 ℃, ingingo yatetse 398.3 ℃, idashonga mumazi, kandi igashonga byoroshye mumashanyarazi. Ibyingenzi biranga ni uko ifite impumuro ndende isa na ambergris, ifite impumuro nziza no gukwirakwizwa gukomeye, bigatuma iba ibikoresho byiza bya parufe yo murwego rwohejuru.
Inkomoko karemano ahanini ni inflorescence n'ibiti n'amababi y'igihingwa cya Lamiaceae Salvia Sclarea L., gihingwa ku rugero runini mu misozi miremire nko mu majyaruguru ya Shaanxi na Honghe, Yunnan, mu Bushinwa. Bitewe nubushyuhe bwinshi butandukanye hagati yumunsi nijoro nubushuhe bukwiye, clarysol muri utwo turere tubyara umusaruro mwinshi kandi ufite impumuro nziza.
Hariho uburyo bwinshi bwingenzi bwo guhuza sclareol:
1
Muri rusange,sclareolibiyikubiyemo bikoreshwa nkibikoresho fatizo byo gukuramo no kwezwa. Ibisigisigi bya sclareol nyuma yo gukuramo amavuta bishonga muri Ethanol, kandi sclareol igwa muburyo bwa inshinge zera nyuma yo gukonjesha ubushyuhe buke, kuyungurura, kuvura karubone, kuyungurura nizindi ntambwe. Nyuma yo kubura umwuma wa centrifugal, kumisha vacuum, kumenagura no gusuzuma, sclareol irimo inzoga nyinshi zirashobora kuboneka.
2. Biosynthesis
Kubaka uruganda rukora inzoga rwenga inzoga: Mu bushakashatsi, synthase ebyiri TPS na LPPs mu munyabwenge zabanje guhuzwa na gene yimisemburo, ibyo bikaba byongereye umusaruro umusarurosclareol. Noneho N-terminus ya TPS-LPPS yahujwe nigice cya proteine ihuza maltose kugirango irusheho kunoza imitekerereze ya enzyme no kongera umusaruro. Hanyuma, itsinda ryubushakashatsi ryagabanyije inzira yose ya metabolike muburyo butatu: inzira yo hagati ya metabolike yo gutanga acetyl coenzyme A, inzira ya isoprenoid biosynthesis inzira hamwe nibintu bigenga uburyo bwo guhindura sisitemu. Mugihe cyo gusana no gusiba genes zimwe na zimwe zifitanye isano, hubatswe umurongo wa chassis ushobora gutanga acetyl-CoA na NADPH neza, kandi umusaruro wa sclareol warushijeho kunozwa no gukabya genes zimwe na zimwe. Hanyuma, ingaruka za buri module kuri synthesis ya sclareol yasesenguwe hifashishijwe imiterere ya metabolike yumurongo wa injeniyeri, kandi byagaragaye ko module eshatu zagize ingaruka zifatika. Federasiyo ya Fed-batch yakorewe muri flake ya shake na bioreactors, hanyuma sclareol ikomatanya neza muri Saccharomyces cerevisiae ikoresheje glucose nkibikoresho fatizo, umusaruro wa 11.4 g / L.
●NikiInyunguBya Sclareol ?
Ubushakashatsi buherutse gukorwa bwerekanye ibikorwa byinshi by’ibinyabuzima bya sclareol, cyane cyane mu bijyanye n’indwara zo mu mitsi yo hagati:
1. Kurwanya inflammatory na neuroprotective:
Irabuza gukora cyane ya microglia, igabanya urwego rwibintu bitera TNF-α na IL-1β, igabanya imvururu mu mbeba ntangarugero ya Parkinson, kandi ikarinda neuron ya dopamine;
Kunoza imikorere yubwenge mubyitegererezo byindwara ya Alzheimer. Igipimo cya 50-200mg / (kg · d) kirashobora kubuza gukora astrocytes mu bwonko no kugabanya imyunyungugu ya β-amyloide.
2. Igikorwa cyo kurwanya antikanseri:
Ifite cytotoxicité ikomeye kumirongo ya kanseri nka leukemia yimbeba (P-388) na epidermal carcinoma yumuntu (KB), kandi ikabuza ikwirakwizwa ryibibyimba itera apoptose.
3. Antibacterial na antioxidant:
Ifite uburyo bwinshi bwo kubuza gukura kwa bagiteri, kandi antioxydeant ikora inshuro 50 za vitamine E, ikwiriye kwambara ibikomere hamwe n’ibicuruzwa byita ku ruhu birwanya gusaza.
●NikiGusabaOf Sclareol ?
1. Inganda zihumura neza n'impumuro nziza:
Nkibikoresho fatizo byibanze bya synthesis ya ambergris, isimbuza ambergris karemano kuva intanga ngabo zibangamiwe. Umubare muto ukoreshwa muburyo butaziguye muri parufe yohejuru kugirango utange impumuro nziza kandi irambuye.
2. Ubushakashatsi bwa farumasi niterambere:
Indwara ya Alzheimer / Imiti yindwara ya Parkinson: capsules yo mu kanwa cyangwa inshinge zinjiye mubushakashatsi bwibanze, bugamije kubuza neuroinflammation;
Kurwanya kanseri bivura imiti: bifatanije n’imiti ya chimiotherapie kugirango byongere ubwicanyi bwibibyimba.
3. Amavuta yo kwisiga n'ibiryo:
Kurwanya gusaza ibicuruzwa byita ku ruhu: ongeramo 0.5% -2% kugirango ubuze gufotora no kugabanya erythema ya ultraviolet;
Ibidukikije byangiza ibidukikije: bikoreshwa mubiribwa byamavuta kugirango wongere igihe cyubuzima, kandi bifite umutekano kuruta ibicuruzwa bya sintetike.
●NEWGREEN Tanga ubuziranengeSclareolIfu
Igihe cyo kohereza: Jun-25-2025
