Chitosan: Inyungu, Porogaramu nibindi

• Niki Chitosan?

Chitosan. Ibikoresho fatizo byibanze bya chitine bingana na 27% byimyanda itunganya urusenda n’igikona, kandi umusaruro wumwaka ku isi urenga toni miliyoni 13. Gukuramo gakondo bisaba inzira eshatu: acide acide decalcification (gushonga calcium karubone), alkaline itetse kugirango ikuremo poroteyine, hamwe na 40-50% yibanze kuri alkali deacetylation, hanyuma ikabona ikintu cyera gifite impamyabumenyi ya deacetylation irenga 70%.

Intambwe imaze guterwa mu myaka yashize ni iterambere rya chitosani ya fungal: chitosani yakuwe mu bihumyo nka Ganoderma lucidum hakoreshejwe uburyo bwa enzymatique ifite urugero rwa deacetylation irenga 85%, uburemere bwa molekuline bwa 1/3 gusa muri ibyo biva muri shrimp na crab (hafi 8-66kDa), kandi ntibufite poroteyine za allergeque. Itsinda ry’ishuri ry’ubumenyi bw’ubuhinzi mu Bushinwa ryagenzuye ko uburyo bwo kuvoma ibihumyo-chitosan bushobora kugenzura itandukaniro ry’ibiro bya molekile muri ± 5%, bigakemura ikibazo cy’imihindagurikire y’ibihe mu bikoresho fatizo byo mu nyanja.

• Ni izihe nyunguChitosan ?

Ihiganwa ryibanze rya chitosan riva mumatsinda ya amino na hydroxyl yubusa kumurongo wacyo wa molekile, bigakora "agasanduku k'ibikoresho" bidasanzwe:

Ubwenge Bwubwenge:amino protonation yemerera chitosan gushonga mubidukikije bya acide, ikagera kurekurwa na pH (nkuburyo bwo kurekura imiti ya anticancer doxorubicin kuri pH 5.0 mumyanya mikorobe yibibyimba ikubye inshuro 7.3 yibidukikije bya physiologique);

Guhuza ibinyabuzima:kwishyurwa kwiza bifatanije nuburyo bubi bwa mucosa kugirango byongere igihe cyo gufata imiti mumyanya yumunwa no munda ya gastrointestinal, kandi gufatira mucosal byiyongera inshuro 3 nyuma yo guhindura thiolation;

Guhuza ibidukikije:Chitosan irashobora guteshwa agaciro na lysozyme (urugero rwo hejuru rwa deacetylation itakaza ibiro 78% mumasaha 72), kandi ibicuruzwa byangirika bigira uruhare mubutaka bwa karubone na azote.

Uburyo bwa Antibacterial Mechanism buragaragara cyane:uburemere buke bwa chitosan bwangiza ubusugire bwa bagiteri, na diameter ya zone yabujijwe kuri Escherichia coli na Staphylococcus aureus ni 13.5mm; ubushobozi bwa antioxydeant burashobora kandi gutesha agaciro ogisijeni ikora iterwa no guhangayikishwa nudukoko twangiza udukoko, bikagabanya malondialdehyde ya epinari ivurwa na chlorpyrifos 40%.

Ni ubuhe buryo bukoreshwaChitosan?

1. Biomedicine: Kuva Kumurongo Kugeza Mrna Urukingo

Sisitemu yo gutanga ubwenge: Uburyo bwo kwanduza CS / pDNA nanocomplex ni ordre 2 z'ubunini burenze ubwa liposomes, bihinduka bishya bikundwa nabatwara gene badafite virusi;

Gusana ibikomere: Ganoderma lucidum chitosan-glucan compte gel igabanya igihe cyo guterana 50%, kandi imiterere-yimiterere-itatu-yihuta yihutisha kuvugurura ingirabuzimafatizo;

Inkingo zihamye: Chitosan ikonjesha-yumye irinda ibintu bituma igipimo cyo kugumana ibikorwa cyurukingo rwa mRNA kirenga 90% mubushyuhe bwicyumba, bikemura ikibazo cyubwikorezi bukonje.

2. Ubuhinzi bwatsi: Urufunguzo rwibidukikije mu kugabanya ikoreshwa ry’ifumbire

Chitosan-ifumbire igenzurwa-ifumbire mvaruganda (CRFs) yongerera imikorere binyuze muburyo butatu:

Kurekurwa kugenewe: Graphene oxyde / chitosan nanofilms ikomeza kurekura azote muminsi 60 mubutaka bwa acide, kandi igipimo cyo kuyikoresha kiri hejuru ya 40% ugereranije na urea yuzuye sulfure;

Kurwanya ibihingwa byangiza ibihingwa: Gutera ibihingwa guhuza chitinase, umusaruro winyanya wiyongereyeho 22%, mugihe ugabanya umuvuduko wumusaruro wa O₂⁻;

Gutezimbere Ubutaka: Ongera ibintu kama inshuro 1.8, kwagura ibikorwa bya actinomycete inshuro 3, kandi bitesha agaciro rwose muminsi 60 nta bisigara.

3. Gupakira ibiryo: Impinduramatwara yo Kurinda Intungamubiri za poroteyine

Itsinda rishya ryishuri ryubushinwa ryubumenyi bwubuhinzi ryahujwechitosanhamwe na poroteyine y'ibiryo hamwe na propolis etanol yuzuye:

Ibikoresho bya mashini: imbaraga zingana ziyongereyeho 200%, kandi inzitizi zamazi ziva mumazi zageze kuri 90% ya firime ishingiye kuri peteroli;

Igikorwa cya Antibacterial: igipimo cya antibacterial ya bagiteri ya strawberry yangirika yarenze 99%, igihe cyo kuramba cyongerewe iminsi 14, naho biodegradation yari 100%.

4. Gucapa imyenda no gusiga irangi: Igisubizo gisanzwe kuri Antiyatike Polyester

Binyuze mu kugabanya kugabanya alkali, ibyobo hamwe na carboxyl bibumbiye hejuru ya polyester. Nyuma ya chitosan ihujwe na aside ya tartaric:

Antistatike ihoraho: kurwanya biragabanuka kuva 10¹²Ω bikagera kuri 10⁴Ω, kandi nubushuhe bugakomeza kuba 6.56% nyuma yo gukaraba 30;

Ibyuma biremereye cyane: Cu²⁰ chelation ikora neza mugucapa no gusiga irangi amazi mabi ni> 90%, kandi ikiguzi ni 1/3 cyibisigarira.

• NEWGREEN Itanga ubuziranengeChitosanIfu