Acide ya Chenodeoxycholic: Ikintu Cyibanze Cyibanze cyo Kuvura Indwara Yumwijima, Ibiryo bikora na Biomaterial

● NikiAcide ya Chenodeoxycholic ?

Acide ya Chenodeoxycholic (CDCA) ni kimwe mu bintu by'ingenzi bigize intanga ngabo, bingana na 30% -40% bya aside aside y'abantu, kandi ibiyirimo ni byinshi cyane mu mara ya za gaseke, inkongoro, ingurube n'andi matungo.

Iterambere mu buhanga bugezweho bwo kuvoma:

Gukuramo COerc birenze urugero: gukuramo ubushyuhe buke nubushyuhe bwo hejuru kugirango wirinde ibisigazwa byumubiri, kandi ubuziranenge bushobora kugera kuri 98%;

Uburyo bwa fermentation ya mikorobe: ukoresheje ubwoko bwa geneti (nka Escherichia coli) muguhuza CDCA, igiciro cyaragabanutseho 40%, ibyo bikaba bijyanye nuburyo bwo gukora imiti yicyatsi kibisi;

Uburyo bwa synthèse chimique: gukoresha cholesterol nkibibanziriza, iboneka binyuze mubyiciro byinshi, bikwiranye nibicuruzwa bya farumasi bifite isuku nyinshi.

Imiterere yumubiri na chimique yaAcide ya Chenodeoxycholic :
Izina ryimiti: 3α, 7α-dihydroxy-5β-acide cholanic (Acide Chenodeoxycholic)
Inzira ya molekulari: C₂₄H₄₀O₄
Uburemere bwa molekuline: 392.58 g / mol
Kugaragara: ifu ya kirisiti yera
Gukemura: gushonga gake mumazi, gushonga byoroshye muri Ethanol, ether, chloroform
Ingingo yo gushonga: 165-168 ℃
Guhagarara: kumva urumuri nubushyuhe, bigomba gukonjeshwa kure yumucyo (2-8 ℃)

Ni izihe nyungu zaAcide ya Chenodeoxycholic ?

1. Gusenya amabuye ya Cholesterol

Mechanism: kubuza umwijima HMG-CoA reductase, kugabanya synthesis ya cholesterol, guteza imbere aside aside, no gushonga buhoro buhoro amabuye ya cholesterol;

Amakuru yubuvuzi: 750mg CDCA kumunsi mumezi 12-24, igipimo cyo gusohora amabuye gishobora kugera kuri 40% -70%.

2. Kuvura Indwara ya Biliary Cholangitis (Pbc)

Imiti yo ku murongo wa mbere: FDA yemeje Chenodeoxycholic Acide CDCA ya PBC, kunoza ibipimo byerekana umwijima (ALT / AST yagabanutse hejuru ya 50%);

Ubuvuzi bwo guhuza: hamweAcide ya Chenodeoxycholichamwe na aside ya ursodeoxycholic (UDCA), imikorere iratera imbere 30%.

3. Kugena Indwara Zi Metabolike

Kugabanya lipide yamaraso: kugabanya serumu yose ya cholesterol (TC) hamwe na lipoprotein nkeya (LDL);

Kurwanya diyabete: kunoza insuline, ubushakashatsi ku nyamaswa bwerekana ko isukari yo mu maraso igabanukaho 20%

4. Kurwanya Kurwanya no Kurinda Immune

Kubuza inzira ya NF-κB no kugabanya kurekura ibintu bitera umuriro (TNF-α, IL-6);

Igeragezwa rya Clinical ryerekanye ko iterambere rya fibrosis yumwijima ku barwayi bafite umwijima w’umwijima utarimo inzoga (NAFLD) urenga 60%.

Ni ubuhe buryo bukoreshwaAcide ya Chenodeoxycholic ?

1. Ubuvuzi

Kuvura amabuye: ibinini bya CDCA (250mg / tablet), ikinini cya buri munsi 10-15mg / kg;

Ubuvuzi bwa PBC: imyiteguro ikomatanyije hamwe na UDCA (nka Ursofalk®), kugurisha buri mwaka kwisi kurenga miliyoni 500 US $;

Ubushakashatsi bwo kurwanya ibibyimba: kubuza ikwirakwizwa rya kanseri y'umwijima kugenga imiti ya FXR, kwinjira mu cyiciro cya kabiri cy’amavuriro.

2. Ibiribwa bikora nibicuruzwa byubuzima

Ibinini birinda umwijima: ifumbire mvaruganda (CDCA + silymarin), kugabanya kwangirika kwumwijima;

Lipid-igabanya capsules: guhuza hamwe numusemburo utukura wumuceri utukura kugirango ugabanye metabolism yamaraso.

3. Ubworozi n'ubworozi bw'amafi

Kugaburira ibiryo: kunoza amatungo n’ibikomoka ku nkoko metabolism, kugabanya ibinure byo munda;

Ubuzima bwamafi: wongeyeho 0.1%acide chenodeoxycholickuzamura indwara ya karp no kongera ubuzima bwo kubaho 15%.

4. Amavuta yo kwisiga no Kwitaho wenyine

Kurwanya inflammatory: 0.5% -1% wongeyeho, kunoza acne no kumva neza uruhu;

Kwita ku mutwe: kubuza Malassezia no kugabanya kubyara dandruff.

Kuva mu kuvoma kwa gakondo kugeza kuri synthesis ya mikorobe, acide chenodeoxycholic irimo guhinduka kuva "mubintu bisanzwe" bihinduka "ubuvuzi bwuzuye". Hamwe n’ubushakashatsi bwimbitse ku ndwara ziterwa na metabolike no kurwanya ibibyimba, CDCA irashobora kuba ibikoresho fatizo byo kuvura indwara z’umwijima, ibiryo bikora ndetse n’ibinyabuzima, biganisha ku ntera nshya y’inganda z’ubuzima miliyari 100.

● NEWGREEN IsokoAcide ya ChenodeoxycholicIfu