Bilirubin: Imyanda ya metabolike cyangwa umurinzi wubuzima?

●Niki Bilirubin?

Bilirubin ni umusaruro wo kubora kwa selile zitukura zishaje. Buri munsi ingirabuzimafatizo zigera kuri miliyoni 2 zisenyuka mu gihimba buri munsi. Hémoglobine yarekuwe ihindurwamo imbaraga mu buryo bwa bilirubin ibinure-soluble indirect, hanyuma igahinduka bilirubin itangirika mu mazi n'umwijima hanyuma igasohoka mu mara binyuze mu mara. Ikintu cyose kidasanzwe muriyi mikorere ya metabolike (nka hemolysis, kwangirika kwumwijima cyangwa inzitizi zifata umwanda) bishobora gutera bilirubin kwirundanya kandi bigatera jaundice.

Ubushakashatsi buheruka gusanga iyo bilirubin yibanze ari≥17.05μmol / L, isano iri hagati ya diyabete na stroke irashobora guhagarikwa, kandi ibyago byo guhura nubwonko kubarwayi ba diyabete yabagabo bigabanuka inshuro 2,67. Uburyo ni ukubuza ibyiyumvo byinshi C-reaction proteine ​​hamwe na sisitemu yo kwirinda indwara ya immunite, gushyira feri kuri "serwakira".

Bilirubin ikurwa mu ngurube no mu mwijima, umwijima w'inka hamwe n'ubwonko. Twageze ku ntera binyuze mu guhanga ikoranabuhanga:

Gukuramo COerc birenze urugero: kugumana ibikoresho bikora munsi yubushyuhe buke, irinde ibisigazwa byumusemburo, kandi wongere ubuziranenge hejuru ya 98%;

Inzira ya hydrolysis ya biologiya: guhindura icyerekezo cya bilirubin glycoside muri aglycones ikora, byongera bioavailable 50%.

●Ni izihe nyungu zaBilirubin ?

1. Kurinda Antioxydeant

Bilirubin ni antioxydants ikomeye ya endogenous mu mubiri, ishobora kwanduza neza radicals yubusa (nka superoxide na hydrogen peroxide) kandi ikagabanya kwangirika kwingutu ya okiside yibice bigize selile, proteyine na ADN. Ubushakashatsi bwerekanye ko bilirubine nkeya ishobora kongera imbaraga mu kurinda selile kwangirika kwa okiside ikoresheje inzira yerekana ibimenyetso bya antioxydeant (nk'inzira ya Nrf2), ndetse ishobora no kugabanya ibyago byo kwandura indwara ya aterosklerozose n'indwara zifata ubwonko.

2. Imikorere yo gukingira indwara

BilirubinIrashobora kugenga ubudahangarwa bw'umubiri ibuza kurekura ibintu bitera umuriro (nka TNF-α na IL-6). Irashobora kugabanya kwangirika kwinyama ziterwa no gutwikwa gukabije mugihe ikomeza kuringaniza sisitemu yumubiri. Kurugero, kuzamura bilirubin byoroheje muri jaundice ya physiologique yibibondo byavutse bishobora gufasha kugabanya ibyago byo kwandura hakoreshejwe ubu buryo. Nyamara, kwibanda cyane birashobora guhagarika ibikorwa byingirabuzimafatizo kandi bikongera kwandura indwara.

3. Ingirabuzimafatizo na neuroprotection

Bilirubin igira ingaruka zidasanzwe zo kurinda sisitemu y'imitsi. Irashobora kurenga inzitizi yubwonko bwamaraso ikanarinda neuron ischemia cyangwa ibikomere byangirika mukurinda glutamate excitotoxicity no kugabanya kwangiza okiside. Byongeye kandi, bilirubin irashobora kandi kugabanya kwangirika kwingirangingo zumwijima, selile myocardial, nibindi munsi ya hypoxia cyangwa toxine, kandi igakomeza imikorere yumubiri.

4. Guteza imbere metabolism no gusohoka

Inzira yo guhinduranya yabilirubinni ihuriro ryingenzi mugutunganya hémoglobine mumubiri. Nyuma ya hemoglobine mu gusaza ingirabuzimafatizo zitukura zangirika muri bilirubine, igomba guhuzwa n'umwijima hanyuma igasohoka mu mara hamwe na bile. Bagiteri zo mu nda zayihindura urobilinogen, igice cyacyo kikaba cyongeye gusubirwamo (enterohepatic circulation), naho ibindi bigasohoka umwanda. Uru ruzinduko ntirufasha gukuraho imyanda ya metabolike gusa, ahubwo runakorana na flora yo munda kugirango bigire ingaruka kuri metabolike muri rusange.

5. Ibibi byinzego zidasanzwe

Bilirubine ikabije: Irashobora gutera jaundice (umuhondo w'uruhu na sclera), ikunze kugaragara muri hepatite, inzitizi ya biliary cyangwa indwara ya hemolitike. Iyo bilirubine yubusa ari ndende cyane, irashobora kunyura kuri bariyeri yubwonko bwamaraso kandi igatera neonatal kernicterus (kwangiza ubwonko).

Bilirubin nkeya cyane: Ubushakashatsi buherutse gukorwa bwerekanye ko kwiyongera kwa bilirubin byoroheje bishobora kugira ingaruka zo kubarinda, mu gihe urwego rwo hasi cyane rushobora kuba rufite ibyago byinshi byo kwandura indwara zifata umutima ndetse n’indwara ziterwa na autoimmune, ariko uburyo bwihariye buracyakenewe kwigwa.

●Ni ubuhe buryo bwo Kwagura Ubuvuzi Bwagutse Bilirubin ?

1. Ibikoresho fatizo bya farumasi

Bilirubin nigice cyingenzi cya bezoar artificiel kandi ikoreshwa mumiti irenga 130, nkimiti yumutima nimiyoboro yimitsi nubwonko bwubwonko (85% bigira ingaruka nziza mugukiza indwara zumutima) hamwe no gutegura gucura.

2. Imyiteguro ya Nano (BRNPs)

Binyuze mu ikoranabuhanga rya nanocarrier, efficacy na intego ya bilirubin byatejwe imbere cyane:

Indwara ikaze yo mu gifu: chitosan-bilirubin (CS-BR), ibuza gusohora kw'ibintu bitera umuriro kandi igatera kuvugurura imitsi.

Umwijima utarimo inzoga: polyethylene glycol-bilirubin (PEG-BR), igabanya ibinure byumwijima 30%, kandi igabanya triglyceride 40%

Psoriasis: hydrogel-bilirubin, itezimbere ibikomere byuruhu, nta burozi bwa sisitemu ya corticosteroide

Indwara: TRPM2 inhibitor A23, ihagarika bilirubin neurotoxicity kandi igabanya ubunini bwa infarct.

Ibindi bikorwa bya bilirubin: ubworozi, kurengera ibidukikije nibicuruzwa bikora

Ubworozi bw'amafi: Ongeramo 4% bilirubin yo kugaburira byikubye kabiri umusaruro wa shrimp yera kandi byongera ibiro bya karpi 155.1%;

Ibiryo bikora: Anti-glycation yo mu kanwa, ifatanije na antioxydeant ya bilirubin kugirango itinde gusaza kwuruhu.

●Isoko Rishya BilirubinIfu