Andrographis Paniculata Ikuramo: Antibacterial ikomeye na Anti-Inflammatory Ibimera byibyatsi

●Niki Andrographis Paniculata Ikuramo?

Andrographis paniculata, izwi kandi ku izina rya "umunezero umwe" n "" ibyatsi bisharira ", ni igihingwa ngarukamwaka cy'ibyatsi byo mu muryango wa Acanthaceae. Ikomoka muri Aziya yepfo nk'Ubuhinde na Sri Lanka, ubu ikaba ikwirakwizwa cyane ahantu h'ubushyuhe n'ubushyuhe nka Guangdong na Fujian mu Bushinwa. Igihingwa cyose kiryoha cyane, gifite urukiramende, amababi ahateganye, nigihe cyo kumera kwa Kanama-Nzeri. Ubuvuzi gakondo bw'Abashinwa bukoresha ingaruka zabwo zo gukuraho ubushyuhe no kwangiza, gukonjesha amaraso no kugabanya kubyimba kuvura ibicurane, umuriro, dysentery, ibisebe no kurumwa n'inzoka. Inganda zigezweho zikuramo ibintu bikora mubiti n'amababi binyuze mu gukuramo COerc ndengakamere hamwe na tekinoroji ya hydrolysis ya bio-enzymatique kugirango ikore ifu isanzwe ifite andrographolide ya 8% -98%, iteza imbere kuzamura imiti y’ibyatsi y’abaturage ikagera ku bikoresho mpuzamahanga bibisi.

Ibyingenzi byingenzi bigizeAndrographis Paniculata EInyandikoni ibimera bya diterpenoid, bingana na 2% -5% 24, cyane cyane harimo:

1.  Andrographolide:amata ya molekuline C₂₀H₃₀O₅, angana na 30% -50%, nicyo kintu nyamukuru gikora antibacterial na anti-inflammatory.
2.  Dehydroandrographolide:molekile ya formula C₂₀H₂₈O₄, gushonga ingingo 204 ℃, hamwe nibikorwa bikomeye byo kurwanya ibibyimba.
3. 14-Deoxyandrographolide:molekulari ya formula C₂₀H₃₀O₄, hamwe nibikorwa byiza birwanya leptospirose.
4. Neoandrographolide:amata ya molekuline C₂₆H₄₀O₈, gukemura neza kwamazi, bikwiranye no gutegura umunwa.

Byongeye kandi, flavonoide, acide fenolike hamwe nibice bya peteroli ihindagurika byongera imbaraga za antioxydeant na immunomodulatory.

●Ni izihe nyungu Andrographis Paniculata Ikuramo?

1. Gukingira no Kurwanya Indwara

Antibacterial na antiviral: Andrographolide ifite igipimo cyo kubuza hejuru ya 90% kuri Staphylococcus aureus na Shigella dysenteriae, kandi ivuriro ryayo mu kuvura indwara ya baciliire igereranywa na chloramphenicol. Amazi akuramo arashobora kugabanya kwandura ibicurane 30% kandi bikagabanya inzira yubukonje 50%.

Immunoenhancement: Mugukoresha macrophage na T lymphocytes T, irashobora kongera urwego rwa CD4⁺ lymphocytes kubarwayi ba virusi itera sida (amakuru yubuvuzi: 405 → 501 / mm³, p = 0.002).

2. Kurwanya Tumor na Angiogenezi Kubuza

Kurwanya ibibyimba bitaziguye: Dehydroandrographolide irashobora kubuza imikurire ya W256 yatewe kandi ikabuza ikwirakwizwa rya kanseri muburyo butandukanye.

Anti-angiogenezi: Andrographolide ihagarika ikibyimba angiogenez mu kugabanya imvugo ya VEGFR2 no guhagarika inzira yerekana ibimenyetso bya ERK / p38, hamwe na IC₅₀ ya 100-200μM.

3. Metabolism no Kurinda Urwego

Kurinda umwijima no kugabanya lipide: Andrographolide ikomeza urugero rwa glutathione kandi igabanya malondialdehyde (MDA) mu buryo bwo gukomeretsa umwijima wa karubone tetrachloride 40%, bikaba byiza kuruta silymarine.

Kurinda umutima-mitsi: Igenga nitric oxyde / endothelin iringaniza, igatinda aterosklerose, kandi ikagabanya urugero rwa lipide yamaraso murukwavu rwubushakashatsi.

4. Anti-Inflammatory na Antioxidant

Amazi avamo uruti afite ubushobozi bukomeye bwo gusiba radicals yubusa (IC₅₀ = 4.42μg / mL), ikora inshuro 4 kurusha antioxydants ya sintetike kandi ikwiriye indwara zidakira.

●Nibiki BikoreshwaAndrographis Paniculata Ikuramo ?

1. Ubuvuzi nubuvuzi

Imiti igabanya ubukana: ikoreshwa muri dysentery ya bagiteri, gutera umusonga no gutegura umunwa kuri pharyngitis, hamwe n’igipimo cyo gukira kiri hejuru ya 85%.

Imiti igamije kurwanya ibibyimba: Inkomoko ya Andrographolide “Andrographine” yinjiye mu cyiciro cya kabiri cy’amavuriro y’indwara ya leukemia n’ibibyimba bikomeye.

Gucunga indwara zidakira: kuvura indwara ya retinopathie diabete (0.5-2mg / kg / kumunsi) na rubagimpande ya rubagimpande (1-3mg / kg / kumunsi).

2. Ubworozi n'ubworozi bw'icyatsi

Ubundi antibiyotike: Ifumbire mvaruganda ya Andrographis paniculata igabanya ibiryo byimpiswi yingurube kandi byongera ubuzima bwa broilers; wongeyeho 4% ikuramo ibiryo bya karp, igipimo cyo kongera ibiro kigera kuri 155.1%, naho igipimo cyo guhindura ibiryo kikaba cyiza kuri 1.11.

Kwirinda no kurwanya indwara: Andrographis paniculata inshinge ivura umusonga w'ingurube na enteritis, hamwe no gukira kwa 90% naho impfu zikaba 10%.

3. Ibiryo byubuzima nubumara bwa buri munsi

Ibiryo bikora: Andrographis paniculatagukuramocapsules (200mg kumunsi) itangizwa mumasoko yuburayi na Amerika kugirango igabanye ubudahangarwa no kwirinda ubukonje.

Ibicuruzwa byita ku ruhu: Ongeraho ibintu birwanya inflammatory hamwe nizuba kugirango bigabanye kwangirika kwa UV no gutukura kwuruhu rworoshye.

4. Ibimaze kugerwaho mumirima igaragara

Imiti igabanya ubukana: Iterambere ryimyiteguro yibibyimba na retinopathie diabete byabaye icyerekezo cyingenzi cya biologiya.

Ubuvuzi bw'amatungo: Ibirwanya anti-inflammatory na immunomodulatory ku mbwa n'injangwe byatangijwe ku isoko ryo muri Amerika y'Amajyaruguru, buri mwaka ikiyongera rya 35%.

●Isoko RishyaAndrographis Paniculata IkuramoIfu