● Nikiβ-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) ni coenzyme y'ingenzi iboneka mu ngirabuzimafatizo zose, hamwe na formula ya molekuline ya C₂₁H₂₇N₇O₁₄P₂, n'uburemere bwa molekile ya 663.43. Nkibintu nyamukuru bitwara redox reaction, kwibanda kwayo kugena neza imikorere ya metabolisme yingirabuzimafatizo kandi bizwi nk "ifaranga ryingirabuzimafatizo".
Ibiranga isaranganya kamere:
Itandukaniro ryinyama: Ibiri muri selile myocardial ni byo hejuru (hafi 0.3-0.5 mM), bigakurikirwa numwijima, naho hasi cyane muruhu (bigabanukaho 50% buri myaka 20 hamwe nimyaka);
Ifishi iriho: harimo ifishi ya okiside (NAD⁺) hamwe nuburyo bwagabanijwe (NADH), hamwe nuburinganire bwimiterere yikigereranyo hagati yibi byombi byerekana imiterere ya metabolism selile.
Kurinda imirasire yaβ-NAD.
Ongera igipimo cyo kubaho kwingirangingo ya hematopoietic stem selile nyuma yimirasire inshuro 3, kandi witondere cyane umushinga wubuzima bwo mu kirere NASA.
Inkomoko yo kwitegura: Kuva gukuramo ibinyabuzima kugeza impinduramatwara ya biologiya
1. Uburyo bwo kuvoma gakondo
Ibikoresho bibisi: ingirabuzimafatizo (ibirimo 0.1% -0.3%), umwijima w'inyamaswa;
Inzira: gusya ultrasonic → ion guhana chromatografiya → guhagarika gukama,β-NADubuziranenge ≥ 95%.
2. Enzyme catalytic synthesis (inzira nyamukuru)
Substrate: Nicotinamide + 5'-fosiforiibosyl pyrophosifate (PRPP);
Ibyiza: Ikoreshwa rya enzyme yimisemburo irashobora kongera umusaruro wa β-NAD kugeza kuri 97%.
3. Ibinyabuzima bya sintetike (icyerekezo kizaza)
Gene yahinduwe na Escherichia coli:Imashini yakozwe na ChromaDex, muri Amerika, hamwe na fermentation ya 6 g / L;
Umuco w'utugingo ngengabuzima: Imizi yimisatsi yimisatsi itunganya umusaruro munini wa NAD ibanziriza NR.
Ni izihe nyungu zaβ-NAD?
1. Uburyo bwo kurwanya gusaza
Koresha Sirtuins:Ongera ibikorwa bya SIRT1 / 3 inshuro 3-5, gusana ibyangiritse kuri ADN, no kongera igihe cy'umusemburo 31%;
Imbaraga za Mitochondrial:Ubushakashatsi ku mavuriro bwerekana ko abantu bafite hagati y’imyaka 50-70 bongera 500 mg NMN buri munsi, kandi imitsi ya ATP yiyongera 25% nyuma yibyumweru 6.
2. Neuroprotection
Indwara ya Alzheimer:Kugarura urwego rwa NAD⁺ urwego rushobora kugabanya β-amyloide, kandi imikorere yubwenge yimiterere yimbeba itera imbere 40%;
Indwara ya Parkinson: β-NADKurinda neuron ya dopaminergique ukoresheje PARP1 kubuza.
3. Gutabara indwara ya metabolike
Diyabete:Kongera imbaraga za insuline, ubushakashatsi bwimbeba zifite umubyibuho ukabije bwerekana igabanuka rya 30% byisukari yamaraso;
Kurinda umutima n'imitsi:Kunoza imikorere ya endoteliyale, no kugabanya ubuso bwa plaque ya atherosklerotike 50%.
Ni ubuhe buryo bukoreshwaβ-NAD?
1. Ubuvuzi
Imiti irwanya gusaza: Imyiteguro myinshi ya NMN yemejwe ko ari imiti yimfubyi na FDA ya myopathie mitochondrial;
Indwara zifata ubwonko: Gutera inshinge NAD⁺ zinjiye mu cyiciro cya kabiri cy’amavuriro (ibimenyetso byindwara ya Alzheimer).
2. Ibiryo bikora
Inyongera mu kanwa: β-NADnka NAD ibanziriza (NR / NMN) capsules igurishwa buri mwaka irenga miliyoni 500.
Imirire ya siporo:Kunoza kwihangana kwabakinnyi, kandi hariho abashoramari ba NAD ku isoko kugirango bongere imikorere ya siporo.
3. Guhanga udushya
Kurwanya gusaza:0.1% -1% NAD⁺ igoye, yageragejwe kugabanya ubujyakuzimu bwa 37%;
Kwita ku mutwe:Kora imisatsi yumusemburo wumusatsi, hanyuma wongere NAD yongera imbaraga muri shampoo yo kurwanya umusatsi.
4. Ubuhinzi nubushakashatsi bwa siyansi
Ubuzima bw'inyamaswa:Ongeraho NAD ibanziriza kubiba ibiryo byongera umubare wingurube 15%;
Kumenya ibinyabuzima:Ikigereranyo cya NAD / NADH gikoreshwa nk'ikimenyetso cyerekana imiterere ya selile yo gusuzuma kanseri hakiri kare.
●Isoko Rishyaβ-NADIfu
Igihe cyo kohereza: Jun-17-2025
