●KodiSclareol ?
Sclareol, dzina la mankhwala (1R,2R,8aS) -decahydro-1-(3-hydroxy-3-methyl-4-pentenyl) -2,5,5,8a-tetramethyl-2-naphthol, ndondomeko ya molekyulu C₂₀H₃₆O₂, molekyulu yolemera 308.350-307-CAS 308.350-300-300. Ndi bicyclic diterpenoid pawiri, yokhala ndi mawonekedwe a ufa woyera wa crystalline, malo osungunuka 95-105 ℃, malo otentha 398.3 ℃, osasungunuka m'madzi, komanso osungunuka mosavuta mu zosungunulira za organic. Chikhalidwe chake chachikulu ndi chakuti ali ndi fungo lokhalitsa lofanana ndi ambergris, lokhala ndi fungo labwino komanso lofalikira kwambiri, zomwe zimapangitsa kuti zikhale zopangira mafuta onunkhira apamwamba.
Magwero achilengedwe makamaka ndi inflorescence ndi zimayambira ndi masamba a chomera cha Lamiaceae Salvia Sclarea L., chomwe chimalimidwa pamlingo waukulu kumadera amapiri okwera kwambiri monga kumpoto kwa Shaanxi ndi Honghe, Yunnan, China. Chifukwa cha kusiyana kwakukulu kwa kutentha pakati pa usana ndi usiku ndi chinyezi choyenera, clarysol m'madera opangira izi ndi yoyera kwambiri komanso yonunkhira bwino.
Pali njira zingapo zopangira sclareol:
1. Kaphatikizidwe ka mankhwala
Nthawi zambiri,sclareolTingafinye ntchito ngati zopangira kwa m'zigawo ndi kuyeretsa. Zotsalira za sclareol pambuyo pochotsa mafuta zimasungunuka mu ethanol, ndipo sclareol imalowetsedwa mu mawonekedwe a singano zoyera pambuyo pa kuzizira kwa kutentha, kusefa, mankhwala a carbon, dilution ndi masitepe ena. Pambuyo pa centrifugal kutaya madzi m'thupi, kuyanika kwa vacuum, kuphwanya ndi kuwunika, sclareol yokhala ndi mowa wambiri imatha kupezeka.
2. Biosynthesis
Kupanga fakitale ya yisiti ya brewer's yeast cell: Mu kafukufukuyu, ma synthase awiri a TPS ndi LPPs mu sage adaphatikizidwa koyamba ku jini ya yisiti, yomwe idakulitsa kupanga kwasclareol. Kenako N-terminus ya TPS-LPPS idalumikizidwa ndi gawo la mapuloteni omangira maltose kuti apititse patsogolo kukhazikika kwa enzyme ndikuwonjezera zokolola kachiwiri. Kenako, gulu lofufuzalo linagawa njira yonse ya kagayidwe kachakudya m'magawo atatu: njira yapakati ya metabolic yoperekera acetyl coenzyme A, isoprenoid biosynthesis pathway ndi regulatory factor module for system transformation. Pobwezeretsanso ndikuchotsa majini ena ofananirako, mtundu wa chassis womwe umatha kupereka acetyl-CoA ndi NADPH bwino udapangidwa, ndipo zokolola za sclareol zidapititsidwa patsogolo pofotokozera majini ena. Potsirizira pake, zotsatira za module iliyonse pa kaphatikizidwe ka sclareol zinafufuzidwa kupyolera mu mbiri ya kagayidwe kameneka kameneka kamene kanapangidwa, ndipo zinapezeka kuti ma modules atatu anali ndi synergistic effect. Kuwotchera kwa Fed-batch kunkachitika mu ma shake flasks ndi bioreactors, ndipo pamapeto pake sclareol idapangidwa bwino mu Saccharomyces cerevisiae pogwiritsa ntchito shuga monga zopangira, zokolola za 11.4 g/L.
●Ndi ChiyaniUbwinoZa Sclareol ?
Kafukufuku waposachedwa wawonetsa kuti sclareol imagwira ntchito zosiyanasiyana, makamaka pankhani ya matenda amitsempha yapakati:
1. Anti-inflammatory and neuroprotective:
Imalepheretsa kuyambitsa kwambiri kwa microglia, imachepetsa kuchuluka kwa zinthu zotupa TNF-α ndi IL-1β, imachepetsa kusokonezeka kwa kayendedwe ka mbewa za Parkinson, ndikuteteza dopamine neurons;
Kupititsa patsogolo ntchito zamatenda mumitundu ya matenda a Alzheimer's. Mlingo wa 50-200mg/(kg·d) ukhoza kulepheretsa kutsegulira kwa astrocyte mu ubongo ndi kuchepetsa kuyika kwa mapuloteni a β-amyloid.
2. Zochita zolimbana ndi khansa:
Ili ndi cytotoxicity yolimba ku maselo a khansa monga mbewa leukemia (P-388) ndi human epidermal carcinoma (KB), ndipo imalepheretsa kuchulukana kwa chotupa poyambitsa apoptosis.
3. Antibacterial ndi antioxidant:
Ili ndi kuchuluka kwakukulu koletsa kukula kwa bakiteriya, ndipo mphamvu yake yoteteza antioxidant ndi kuwirikiza 50 kuposa ya vitamini E, yomwe ili yoyenera kuvala mabala ndi mankhwala oletsa kukalamba akhungu.
●Ndi ChiyaniKugwiritsa ntchitoOf Sclareol ?
1. Makampani opanga zonunkhira ndi zonunkhira:
Monga chinthu chachikulu chomwe chimapangidwira kupanga ambergris, chimalowa m'malo mwa ambergris achilengedwe kuchokera ku anamgumi omwe ali pangozi. Zochepa zimagwiritsidwa ntchito mwachindunji muzonunkhira zapamwamba kuti fungo likhale losatha komanso losanjikiza.
2. Kafukufuku wamankhwala ndi chitukuko:
Matenda a Alzheimer's / Parkinson's disease mankhwala: makapisozi am'kamwa kapena jekeseni alowa mu kafukufuku wamankhwala, akutsata kuletsa kwa neuroinflammation;
Anti-cancer adjuvant therapy: kuphatikiza ndi mankhwala a chemotherapy kuti apititse patsogolo kupha maselo a chotupa.
3. Zodzoladzola ndi chakudya:
Mankhwala osamalira khungu okalamba: onjezani 0.5% -2% kuti mulepheretse kujambula ndi kuchepetsa ultraviolet erythema;
Zosungira zachilengedwe: zomwe zimagwiritsidwa ntchito muzakudya zamafuta kuti ziwonjezere moyo wa alumali, ndipo ndizotetezeka kuposa zopangidwa ndi mankhwala.
●NEWGREEN Supply High QualitySclareolUfa
Nthawi yotumiza: Jul-18-2025
