Chenodeoxycholic Acid: A Core Raw Material Pachiwindi cha Matenda a Chiwindi, Zakudya Zogwira Ntchito Ndi Zamoyo.

● KodiChenodeoxycholic Acid ?

Chenodeoxycholic Acid (CDCA) ndi imodzi mwa zigawo zikuluzikulu za ndulu ya ndulu, yomwe imawerengera 30% -40% ya asidi ya ndulu yamunthu, ndipo zomwe zili mumtundu wa atsekwe, abakha, nkhumba ndi nyama zina zimakhala zambiri.

Zotsogola muukadaulo wamakono wotulutsa:

Supercritical CO₂ m'zigawo: m'zigawo pansi kutentha otsika ndi mikhalidwe kuthamanga kwambiri kupewa zotsalira zosungunulira organic, ndipo chiyero akhoza kufika oposa 98%;

Njira yowotchera tizilombo tating'onoting'ono: kugwiritsa ntchito mitundu yopangidwa ndi majini (monga Escherichia coli) kupanga CDCA, mtengo wake umachepetsedwa ndi 40%, zomwe zikugwirizana ndi zomwe zimachitika popanga mankhwala obiriwira;

Njira yophatikizira mankhwala: kugwiritsa ntchito cholesterol ngati kalambulabwalo, imapezedwa kudzera munjira zingapo, yoyenera pazamankhwala apamwamba kwambiri.

Thupi ndi mankhwala katundu waChenodeoxycholic Acid :
Dzina la mankhwala: 3α,7α-dihydroxy-5β-cholanic acid (Chenodeoxycholic Acid)
Mapangidwe a maselo: C₂₄H₄₀O₄
Kulemera kwa molekyulu: 392.58 g/mol
Maonekedwe: ufa woyera wa crystalline
Kusungunuka: Kusungunuka pang'ono m'madzi, kusungunuka mosavuta mu Mowa, etha, chloroform
Malo osungunuka: 165-168 ℃
Kukhazikika: kukhudzidwa ndi kuwala ndi kutentha, kumafunika kusungidwa mufiriji kutali ndi kuwala (2-8 ℃)

● Kodi ubwino wa maseŵeraŵa ndi otaniChenodeoxycholic Acid ?

1. Kusungunuka kwa Miyala ya Cholesterol

Njira: ziletsa chiwindi HMG-CoA reductase, kuchepetsa mafuta m`thupi synthesis, kulimbikitsa bile acid katulutsidwe, ndipo pang`onopang`ono kupasuka mafuta m`thupi ndulu;

Deta yachipatala: 750mg CDCA patsiku kwa miyezi 12-24, kusungunuka kwa ndulu kumatha kufika 40% -70%.

2. Chithandizo cha Primary Biliary Cholangitis (Pbc)

Mankhwala a mzere woyamba: FDA inavomereza Chenodeoxycholic Acid CDCA kwa PBC, kusintha zizindikiro za chiwindi (ALT / AST kuchepetsedwa ndi 50%);

Kuphatikiza mankhwala: kuphatikizaChenodeoxycholic Acidndi ursodeoxycholic acid (UDCA), mphamvu yake imakula ndi 30%.

3. Kuwongolera Matenda a Metabolic

Kutsitsa lipids m'magazi: kutsitsa cholesterol chonse (TC) ndi low-density lipoprotein (LDL);

Anti-diabetes: kukulitsa chidwi cha insulin, kuyesa kwa nyama kukuwonetsa kuti shuga wamagazi amatsika ndi 20%

4. Anti-Inflammatory And Immune Regulation

Kuletsa njira ya NF-κB ndikuchepetsa kutulutsidwa kwa zinthu zotupa (TNF-α, IL-6);

Mayesero azachipatala awonetsa kuti kusintha kwa chiwindi cha fibrosis kwa odwala omwe ali ndi matenda osamwa mowa (NAFLD) amaposa 60%.

● Kodi Ma Applications Ndi ChiyaniChenodeoxycholic Acid ?

1. Medical Field

Chithandizo cha gallstone: mapiritsi a CDCA (250mg / piritsi), mlingo wa tsiku ndi tsiku 10-15mg / kg;

Chithandizo cha PBC: kukonzekera kophatikizana ndi UDCA (monga Ursofalk®), kugulitsa kwapachaka kwapadziko lonse kumaposa US $ 500 miliyoni;

Kafukufuku wotsutsana ndi chotupa: kuletsa kuchuluka kwa maselo a khansa ya chiwindi mwa kuwongolera ma FXR receptors, kulowa m'mayesero azachipatala a Phase II.

2. Zakudya Zogwira Ntchito Ndi Zaumoyo

Mapiritsi oteteza chiwindi: mawonekedwe apawiri (CDCA + silymarin), kuchepetsa kuwonongeka kwa chiwindi cha mowa;

Makapisozi otsitsa lipid: olumikizana ndi yisiti yofiira ya mpunga wothira kuwongolera kagayidwe ka lipid m'magazi.

3. Kuweta Ziweto Ndi Ulimi

Zakudya zowonjezera: kusintha mafuta a nyama ndi nkhuku, kuchepetsa mafuta m'mimba;

Thanzi la nsomba: kuwonjezera 0.1%chenodeoxycholic acidkukulitsa kukana matenda a carp ndikuwonjezera kupulumuka ndi 15%.

4. Zodzoladzola Ndi Kusamalira Munthu

Anti-yotupa akamanena: 0.5% -1% Kuwonjezera, kusintha ziphuphu zakumaso ndi khungu tilinazo;

Kusamalira m'mutu: kuletsa Malassezia ndikuchepetsa kupanga dandruff.

Kuchokera ku chikhalidwe cha bile mpaka kuphatikizika kwa tizilombo tating'onoting'ono, chenodeoxycholic acid ikusintha kuchoka ku "chilengedwe" kukhala "mankhwala olondola". Ndikukula kwa kafukufuku wamatenda a metabolic ndi anti-chotupa, CDCA ikhoza kukhala maziko opangira chithandizo cha matenda a chiwindi, zakudya zogwira ntchito komanso ma biomaterials, kutsogoza funde latsopano lamakampani azaumoyo a 100 biliyoni.

● Zatsopano ZatsopanoChenodeoxycholic AcidUfa