●Ndi chiyani Bilirubin?
Bilirubin ndi chotulukapo cha kuwonongeka kwa maselo ofiira okalamba. Pafupifupi 2 miliyoni maselo ofiira a magazi amawonongeka mu ndulu tsiku lililonse. Hemoglobin yotulutsidwa imasinthidwa kukhala bilirubin yosungunuka m'madzi, yomwe imasinthidwa kukhala bilirubin yosungunuka m'madzi ndi chiwindi ndipo pamapeto pake imatulutsidwa m'matumbo kudzera mu bile. Vuto lililonse la kagayidwe kachakudya kameneka (monga hemolysis, kuwonongeka kwa chiwindi kapena kutsekeka kwa ndulu) kungayambitse kuchuluka kwa bilirubin ndikuyambitsa jaundice.
Kafukufuku waposachedwa adapeza kuti pamene ndende ya bilirubin ili≥17.05μmol/L, mgwirizano pakati pa matenda a shuga ndi sitiroko ukhoza kutsekedwa, ndipo chiopsezo cha sitiroko mwa amuna omwe ali ndi matenda a shuga chimachepetsedwa ndi 2.67. Njirayi ndi yolepheretsa mapuloteni apamwamba a C-reactive ndi ndondomeko ya chitetezo cha mthupi, ndikuyika mabuleki pa "mkuntho wotupa".
Bilirubin amachotsedwa ku chiwindi cha nkhumba ndi shark, ndulu ya ng'ombe ndi ubongo. Tapeza zopambana kudzera muukadaulo waukadaulo:
Supercritical CO₂ m'zigawo: sungani zosakaniza zogwira ntchito pansi pa kutentha kochepa, pewani zotsalira zosungunulira, ndikuwonjezera chiyero kupitirira 98%;
Biological enzymatic hydrolysis process: kutembenuka kwa bilirubin glycosides kukhala ma aglycones, ndikuwonjezera bioavailability ndi 50%.
●Ubwino wake ndi chiyaniBilirubin ?
1. Chitetezo cha Antioxidant
Bilirubin ndi yofunika amkati antioxidant m'thupi, amene bwino neutralize ufulu ankafuna kusintha zinthu mopitirira (monga superoxide ndi hydrogen peroxide) ndi kuchepetsa kuwonongeka kwa okosijeni nkhawa nembanemba maselo, mapuloteni ndi DNA. Kafukufuku wasonyeza kuti kuchepa kwa bilirubin kumatha kulimbikitsa chitetezo cha selo kuti chisawonongeke ndi okosijeni mwa kuyambitsa njira zowonetsera antioxidant (monga njira ya Nrf2), ndipo zingathe kuchepetsa chiopsezo cha atherosclerosis ndi matenda a neurodegenerative.
2. Ntchito ya Immunomodulatory
Bilirubinimatha kuwongolera mayankho a chitetezo chamthupi mwa kuletsa kutulutsa zinthu zotupa (monga TNF-α ndi IL-6). Ikhoza kuchepetsa kuwonongeka kwa minofu yomwe imabwera chifukwa cha kutupa kwambiri pamene ikusunga chitetezo cha mthupi. Mwachitsanzo, kutsika pang'ono kwa bilirubin m'thupi la jaundice akhanda kungathandize kuchepetsa chiopsezo cha matenda kudzera mu njirayi. Komabe, kuchulukirachulukira kumatha kulepheretsa magwiridwe antchito a chitetezo chamthupi ndikuwonjezera kutengeka ndi matenda.
3. Maselo ndi neuroprotection
Bilirubin imakhala ndi chitetezo chapadera pamanjenje. Imatha kuwoloka chotchinga chamagazi-muubongo ndikuteteza ma neurons ku ischemia kapena zotupa zowonongeka mwa kuletsa glutamate excitotoxicity ndikuchepetsa kuwonongeka kwa okosijeni. Kuonjezera apo, bilirubin ikhoza kuchepetsanso kuwonongeka kwa maselo a chiwindi, maselo a myocardial, etc. pansi pa hypoxia kapena poizoni, ndikusunga chiwalo.
4. Limbikitsani kagayidwe kagayidwe kachakudya ndi kayendedwe ka excretion
Njira ya metabolicbilirubinndi gawo lofunikira pakubwezeretsanso hemoglobin m'thupi. Pambuyo pakuwonongeka kwa hemoglobin mu ukalamba maselo ofiira a magazi, bilirubin iyenera kuphatikizidwa ndi chiwindi ndikutulutsidwa m'matumbo ndi bile. Mabakiteriya a m'matumbo amasintha kukhala urobilinogen, yomwe mbali yake imalowetsedwanso (kufalikira kwa enterohepatic), ndipo ena onse amachotsedwa ndi ndowe. Kuzungulira uku sikumangothandiza kuchotsa zinyalala za kagayidwe kachakudya, komanso kumalumikizana ndi zomera zam'mimba kuti zikhudze kuchuluka kwa kagayidwe kachakudya.
5. Kuwonongeka kwa milingo yachilendo
Kuchuluka kwa bilirubin: Kungayambitse jaundice (khungu lachikasu ndi sclera), lomwe limakonda kwambiri matenda a chiwindi, kutsekeka kwa biliary kapena matenda a hemolytic. Bilirubin yaulere ikakwera kwambiri, imatha kudutsa chotchinga chamagazi ndi ubongo ndikuyambitsa neonatal kernicterus (kuwonongeka kwaubongo).
Kutsika kwambiri kwa bilirubin: Kafukufuku waposachedwapa wapeza kuti kuwonjezeka pang'ono kwa bilirubin kungakhale ndi zotsatira zotetezera, pamene kuchepa kwambiri kungagwirizane ndi chiopsezo chowonjezereka cha matenda a mtima ndi matenda a autoimmune, koma njira yeniyeniyo iyenera kuwerengedwabe.
●Kodi Kukula kwa Ntchito Yachipatala Ndi Chiyani Bilirubin ?
1. Zida zopangira mankhwala
Bilirubin ndiye chigawo chachikulu cha bezoar yokumba ndipo amagwiritsidwa ntchito pamankhwala opitilira 130, monga mankhwala amtima ndi mitsempha yamagazi (85% yothandiza pochotsa matenda amtima) komanso kukonzekera kwanthawi yosiya kusamba.
2. Kukonzekera kwa Nano (BRNPs)
Kupyolera muukadaulo wa nanocarrier, mphamvu ndi kulunjika kwa bilirubin zasinthidwa kwambiri:
Acute gastric ulcer: chitosan-bilirubin (CS-BR), imalepheretsa katulutsidwe ka zinthu zotupa komanso imathandizira kusinthika kwa mucosal.
Chiwindi chamafuta osaledzeretsa: polyethylene glycol-bilirubin (PEG-BR), amachepetsa kuchuluka kwa mafuta m'chiwindi ndi 30%, komanso amachepetsa triglycerides ndi 40%.
Psoriasis: hydrogelbilirubin, kusintha zotupa pakhungu, popanda zokhudza zonse kawopsedwe wa corticosteroids
Stroke: TRPM2 channel inhibitor A23, imatchinga bilirubin neurotoxicity ndikuchepetsa kukula kwa infarct.
Ntchito zina za bilirubin: kuweta nyama, kuteteza chilengedwe ndi zinthu zogwira ntchito
Ulimi wa Aquaculture: Kuwonjezera 4% bilirubin kudyetsa kuwirikiza kawiri kaphatikizidwe ka shrimp yoyera ndikuwonjezera kulemera kwa carp ndi 155.1%;
Chakudya chogwira ntchito: Anti-glycation pakamwa pakamwa, kuphatikiza ndi antioxidant katundu wa bilirubin kuti achedwetse kukalamba kwa khungu.
●NEWGREEN Supply BilirubinUfa
Nthawi yotumiza: Jun-09-2025
