Andrographis Paniculata Extract: Mankhwala Amphamvu Oletsa Bakiteriya Komanso Oletsa Kutupa

●Ndi chiyani Andrographis Paniculata Extract?

Andrographis paniculata, yomwe imadziwikanso kuti "chimwemwe cha nthawi imodzi" ndi "udzu wowawa", ndi chomera cha pachaka cha herbaceous cha banja la Acanthaceae. Amachokera ku South Asia monga India ndi Sri Lanka, ndipo tsopano amafalitsidwa kwambiri m'madera amvula komanso otentha monga Guangdong ndi Fujian ku China. Chomera chonsecho chimakhala chowawa kwambiri, chokhala ndi tsinde lalikulu, masamba otsutsana, ndi nthawi yamaluwa ya August-September. Traditional Chinese mankhwala amagwiritsa ntchito zotsatira zake kuchotsa kutentha ndi detoxifying, kuziziritsa magazi ndi kuchepetsa kutupa kuchiza chimfine, malungo, kamwazi, zilonda ndi njoka kulumidwa. Makampani amakono amatulutsa zosakaniza zogwira ntchito kuchokera ku tsinde ndi masamba kudzera muukadaulo wapamwamba kwambiri wa CO₂ ndi ukadaulo wa bio-enzymatic hydrolysis kuti apange ufa wokhazikika wokhala ndi andrographolide wokhala ndi 8% -98%, kulimbikitsa kukweza kwake kuchokera kumankhwala azitsamba owerengeka kupita kuzinthu zapadziko lonse lapansi.

Pakatikati yogwira zosakaniza zaAndrographis Paniculata Extractsndi diterpenoid lactone mankhwala, mlandu 2% -5%24, makamaka kuphatikizapo:

1.  Andrographolide:formula ya maselo C₂₀H₃₀O₅, yowerengera 30% -50%, ndiye chinthu chachikulu chomwe chimagwira ntchito pa antibacterial ndi anti-inflammatory.
2.  Dehydroandrographolide:formula ya maselo C₂₀H₂₈O₄, malo osungunuka 204 ℃, okhala ndi ntchito yayikulu yolimbana ndi chotupa.
3. 14-Deoxyandrographolide:formula ya maselo C₂₀H₃₀O₄, yokhala ndi mphamvu yolimbana ndi leptospirosis.
4. Neoandrographolide:formula molecular C₂₆H₄₀O₈, madzi abwino kusungunuka, oyenera kukonzekera pakamwa.

Kuphatikiza apo, flavonoids, phenolic acid ndi zigawo zamafuta zomwe zimasokonekera zimawonjezera ntchito za antioxidant ndi immunomodulatory.

●Kodi Ubwino Wake Ndi Chiyani Andrographis Paniculata Extract?

1. Immunomodulation Ndi Anti-Infection

Antibacterial ndi antiviral: Andrographolide ili ndi chiletso choposa 90% pa Staphylococcus aureus ndi Shigella dysenteriae, ndipo mphamvu yake yachipatala pochiza bacillary kamwazi ndi yofanana ndi chloramphenicol. Madzi ake amadzimadzi amatha kuchepetsa chimfine ndi 30% ndikufupikitsa chimfine ndi 50%.

Immunoenhancement: Poyambitsa ma macrophages ndi T lymphocytes, amatha kuwonjezera kuchuluka kwa CD4⁺ lymphocytes mwa odwala omwe ali ndi kachilombo ka HIV (deta yachipatala: 405→501/mm³, p=0.002).

2. Anti-Tumor Ndi Angiogenesis Inhibition

Direct anti-chotupa: Dehydroandrographolide imatha kuletsa kukula kwa zotupa zosinthidwa za W256 ndikuletsa kuchuluka kwa maselo a khansa m'njira yodalira mlingo.

Anti-angiogenesis: Andrographolide imatchinga chotupa cha angiogenesis mwa kuchepetsa mawu a VEGFR2 ndikuletsa njira yowonetsera ERK/p38, ndi IC₅₀ ya 100-200μM.

3. Metabolism Ndi Chitetezo cha Ziwalo

Kuteteza chiwindi ndi kuchepetsa lipids: Andrographolide imasunga milingo ya glutathione ndipo imachepetsa malondialdehyde (MDA) mu chitsanzo cha kuvulala kwa chiwindi cha carbon tetrachloride ndi 40%, yomwe ili bwino kuposa silymarin.

Chitetezo cha mtima: Imawongolera bwino kwa nitric oxide/endothelin, kuchedwetsa matenda a atherosclerosis, komanso kumachepetsa kuchuluka kwa lipid m'magazi mwa akalulu oyesera.

4. Anti-Inflammatory And Antioxidant

Madzi a m'madzi a tsinde ali ndi mphamvu zowononga zowonongeka (IC₅₀=4.42μg/mL), zomwe zimakhala zogwira mtima nthawi 4 kuposa mankhwala ophera tizilombo toyambitsa matenda ndipo ndi oyenerera matenda otupa osatha.

●Kodi Ma Applications Ndi ChiyaniAndrographis Paniculata Extract ?

1. Mankhwala Ndi Chithandizo Chachipatala

Anti-infective mankhwala: ntchito bakiteriya kamwazi, chibayo jekeseni ndi m`kamwa kukonzekera pharyngitis, ndi matenda mankhwala mlingo wa pa 85%.

Mankhwala olimbana ndi chotupa: Andrographolide derivative "Andrographine" walowa mu Phase II mayesero azachipatala a khansa ya m'magazi ndi zotupa zolimba.

Kusamalira matenda osachiritsika: chithandizo chothandizira cha matenda ashuga retinopathy (0.5-2mg/kg/tsiku) ndi nyamakazi ya nyamakazi (1-3mg/kg/tsiku).

2. Kuweta Ziweto Ndi Kuweta Zobiriwira

Njira zina zophera tizilombo toyambitsa matenda: Compound Andrographis paniculata zowonjezera zakudya zimachepetsa kutsekula m'mimba kwa ana a nkhumba komanso kuonjezera moyo wa ana a nkhuku; kuwonjezera 4% kuchotsa ku chakudya cha carp, kulemera kwa kulemera kumafika pa 155.1%, ndipo kutembenuka kwa chakudya kumakongoletsedwa ku 1.11.

Kupewa ndi kuwongolera matenda: Jakisoni wa Andrographis paniculata amachiritsa chibayo cha nkhumba ndi enteritis, ndi chiwopsezo cha 90% ndi kufa kwa 10%.

3. Health Food And Daily Chemicals

Chakudya chogwira ntchito: Andrographis paniculatakuchotsamakapisozi (200mg patsiku) amayambitsidwa m'misika ya ku Europe ndi America kuti athetse chitetezo chamthupi komanso kupewa kuzizira.

Zosamalira pakhungu: Onjezani ku zinthu zotsutsana ndi kutupa ndi zoteteza ku dzuwa kuti muchepetse kuwonongeka kwa UV ndi kufiira kwa khungu lovuta.

4. Zotsogola M'magawo Atsopano

Anti-angiogenic mankhwala: Kupanga kokonzekera kwa zotupa ndi matenda a shuga retinopathy kwakhala njira yayikulu yopangira biology.

Chisamaliro cha Pet: Zowonjezera zotsutsana ndi zotupa komanso zoteteza agalu ndi amphaka zimakhazikitsidwa pamsika waku North America, ndikukula kwapachaka kwa 35%.

●NEWGREEN SupplyAndrographis Paniculata ExtractUfa