● Kodiβ-NAD pa ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) ndi coenzyme yofunikira yomwe imapezeka m'maselo onse amoyo, ndi ndondomeko ya molekyulu ya C₂₁H₂₇N₇O₁₄P₂, ndi kulemera kwa molekyulu ya 663.43. Monga chonyamulira chachikulu cha machitidwe a redox, ndende yake imatsimikizira momwe ma cell amagetsi amagwirira ntchito ndipo amadziwika kuti "ndalama yamagetsi yama cell".
Makhalidwe ogawa zachilengedwe:
Kusiyana kwa minofu: Zomwe zili m'maselo a myocardial ndizopamwamba kwambiri (pafupifupi 0.3-0.5 mM), zotsatiridwa ndi chiwindi, ndi zotsika kwambiri pakhungu (zimachepetsa ndi 50% zaka 20 zilizonse ndi zaka);
Mawonekedwe akukhalapo: kuphatikiza mawonekedwe a oxidized (NAD⁺) ndi mawonekedwe ocheperako (NADH), ndipo kuchuluka kwamphamvu kwa chiŵerengero pakati pa ziwirizi kumawonetsa momwe ma cell metabolism.
● Kutetezedwa kwa radiationβ-NAD pa.
Onjezani kuchuluka kwa kupulumuka kwa ma cell a hematopoietic tsinde pambuyo poyatsidwa ndi ma radiation ndi nthawi za 3, ndikulandila chidwi kuchokera ku projekiti ya NASA yazaumoyo.
Kukonzekera kochokera: Kuchokera kuzinthu zachilengedwe kupita ku kusintha kwa biology kupanga
1. Njira yachikhalidwe yochotsera
Zopangira: maselo a yisiti (zomwe zili 0.1% -0.3%), chiwindi cha nyama;
Njira: akupanga kuphwanya → ion kusinthana chromatography → kuzizira kuyanika,β-NAD pachiyero ≥ 95%.
2. Kaphatikizidwe ka enzyme (njira yayikulu)
Gawo laling'ono: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Ubwino: Ukadaulo wa ma enzyme osasunthika utha kukulitsa zokolola za β-NAD mpaka 97%.
3. Synthetic biology (njira yamtsogolo)
Gene-edited Escherichia coli:Mtundu wopangidwa ndi ChromaDex, USA, wokhala ndi zokolola za 6 g/L;
Chikhalidwe cha cell cell: Mizu yaubweya wa fodya imazindikira kupanga kwakukulu kwa NAD precursor NR.
● Kodi ubwino wa maseŵeraŵa ndi otaniβ-NAD pa?
1. Anti-aging core mechanism
Yambitsani Sirtuins:Wonjezerani ntchito ya SIRT1/3 ndi nthawi 3-5, konzani kuwonongeka kwa DNA, ndikuwonjezera moyo wa yisiti ndi 31%;
Mphamvu ya Mitochondrial:Kafukufuku wachipatala amasonyeza kuti anthu a zaka zapakati pa 50-70 amawonjezera 500 mg NMN tsiku lililonse, ndipo kupanga minofu ya ATP kumawonjezeka ndi 25% pambuyo pa masabata a 6.
2. Neuroprotection
Matenda a Alzheimer's:Kubwezeretsa milingo ya neuronal NAD⁺ kumatha kuchepetsa kuyika kwa β-amyloid, ndipo kuzindikira kwamitundu ya mbewa kumakula ndi 40%;
Matenda a Parkinson: β-NAD paTetezani ma dopaminergic neurons kudzera pakuletsa kwa PARP1.
3. Kuthandizira matenda a metabolic
Matenda a shuga:Kupititsa patsogolo chidwi cha insulin, kuyesa kwa mbewa onenepa kumawonetsa kuchepa kwa 30% kwa shuga wamagazi;
Chitetezo cha mtima:Kupititsa patsogolo ntchito ya endothelial, ndikuchepetsa gawo la atherosclerotic plaques ndi 50%.
● Kodi Ma Applications Ndi Chiyaniβ-NAD pa?
1. Ntchito zachipatala
Mankhwala oletsa kukalamba: Kukonzekera kochuluka kwa NMN kwatsimikiziridwa ngati mankhwala a ana amasiye ndi FDA kwa myopathy ya mitochondrial;
Matenda a Neurodegenerative: NAD⁺ jakisoni wamtsempha walowa mu Phase II mayeso azachipatala (zizindikiro za matenda a Alzheimer's).
2. Zakudya zogwira ntchito
Zowonjezera pakamwa: β-NAD pamonga NAD precursor (NR/NMN) makapisozi ali ndi malonda apachaka opitilira $500 miliyoni.
Zakudya zamasewera:Limbikitsani kupirira kwa othamanga, ndipo pali zokhathamiritsa za NAD pamsika kuti zithandizire kuchita bwino pamasewera.
3. Zodzikongoletsera zatsopano
Anti-aging essence:0.1% -1% NAD⁺ zovuta, zoyesedwa kuti zichepetse kuya kwa makwinya ndi 37%;
Kusamalira m'mutu:Yambitsani ma cell amtundu wa tsitsi, ndikuwonjezera zowonjezera za NAD ku shampoo yoletsa kutayika tsitsi.
4. Kafukufuku waulimi ndi sayansi
Umoyo Wanyama:Kuonjezera NAD precursors kubzala chakudya kumawonjezera chiwerengero cha ana a nkhumba ndi 15%;
Kuzindikira kwachilengedwe:Chiwerengero cha NAD/NADH chimagwiritsidwa ntchito ngati chizindikiritso cha cell metabolic state pakuwunika koyambirira kwa khansa.
●NEWGREEN Supplyβ-NAD paUfa
Nthawi yotumiza: Jun-17-2025
