● Gịnị bụβ-NAD ?
β-Nicotinamide Adenine Dinucleotide (β-NAD) bụ isi coenzyme dị na sel niile dị ndụ, nwere usoro molekụla nke C₂₁H₂₇N₇O₁₄P₂, yana ịdị arọ molekụla nke 663.43. Dị ka isi ihe na-ebu mmeghachi omume redox, itinye uche ya na-ekpebi ịdị irè nke metabolism ike cell ma mara dị ka "ego ume cellular".
Njirimara nkesa eke:
Esemokwu anụ ahụ: Ọdịnaya dị na sel myocardial bụ nke kachasị elu (ihe dị ka 0.3-0.5 mM), imeju na-esote ya, na nke kachasị ala na akpụkpọ ahụ (na-ebelata site na 50% kwa afọ 20 ọ bụla na afọ 20);
Ụdị ịdị adị: gụnyere ụdị oxidized (NAD⁺) na ụdị mbelata (NADH), yana nguzozi ike nke oke n'etiti ha abụọ na-egosipụta ọnọdụ nke cellular metabolism.
● Nchekwa radieshon nkeβ-NAD.
Welie ọnụ ọgụgụ nlanarị nke mkpụrụ ndụ hematopoietic mgbe ikpughe radieshon ugboro atọ, wee nweta nlebara anya dị mkpa site na ọrụ ahụike mbara igwe nke NASA.
Isi mmalite nke nkwadebe: Site na mmịpụta ndu na mgbanwe mgbanwe bayoloji sịntetik
1. Usoro mmịpụta ọdịnala
Ihe eji eme ihe: sel yist (ọdịnaya 0.1% -0.3%), imeju anụmanụ;
Usoro: ultrasonic crushing → ion exchange chromatography → ifriizi ihicha,β-NADịdị ọcha ≥ 95%.
2. Enzyme catalytic njikọ (usoro bụ isi)
Mkpụrụ: Nicotinamide + 5'-phosphoribosyl pyrophosphate (PRPP);
Uru: Teknụzụ enzyme na-anaghị emegharị ahụ nwere ike ịbawanye mkpụrụ nke β-NAD ruo 97%.
3. bayoloji sịntetik (ntụziaka n'ọdịnihu)
Escherichia coli deziri mkpụrụ ndụ:Ụdị arụrụ arụrụ arụrụ n'aka ChromaDex, USA, nke nwere mkpụrụ agba agba nke 6 g/L;
Omenala mkpụrụ ndụ osisi: Sistemụ mgbọrọgwụ ntutu ụtaba na-achọpụta nnukwu mmepụta nke NAD precursor NR.
● Gịnị bụ uru nkeβ-NAD?
1. Mgbochi ịka nká isi usoro
Mee Sirtuins rụọ ọrụ:Mụbaa ọrụ SIRT1/3 site na ugboro 3-5, rụkwaa mmebi DNA, wee gbatịa ndụ yist site na 31%;
Ike Mitochondrial:Nnyocha ụlọ ọgwụ na-egosi na ndị dị afọ 50-70 na-agbakwụnye 500 mg NMN kwa ụbọchị, na mmepụta ATP muscle na-abawanye site na 25% mgbe izu isii gachara.
2. Neuroprotection
Ọrịa Alzheimer:Iweghachi ọkwa NAD⁺ neuronal nwere ike ibelata ntinye β-amyloid, yana ọrụ ọgụgụ isi nke ụdị òké na-abawanye site na 40%;
Ọrịa Parkinson: β-NADChebe neurons dopaminergic site na mgbochi PARP1.
3. Ntinye aka nke ọrịa metabolic
Ọrịa shuga:Mee ka mmetụta insulin dịkwuo elu, nnwale oke oke na-egosi mbelata 30% na shuga ọbara;
Nchedo obi obi:Meziwanye ọrụ endothelial, ma belata ebe atherosclerotic plaques site na 50%.
● Gịnị bụ ngwa nkeβ-NAD?
1. Medical ubi
Ọgwụ mgbochi ịka nká: Ọtụtụ NMN akwadoro dị ka ọgwụ ụmụ mgbei site na FDA maka mitochondrial myopathy;
Ọrịa Neurodegenerative: NAD⁺ injection intravenous abanyela ule ụlọ ọgwụ nke Abụọ (ihe ngosi maka ọrịa Alzheimer).
2. Ihe oriri na-arụ ọrụ
Mgbakwụnye ọnụ: β-NADdị ka NAD precursor (NR/NMN) capsules nwere ahịa kwa afọ karịa $500 nde.
Nri egwuregwu:Melite ntachi obi nke ndị na-eme egwuregwu, yana enwere ụfọdụ ndị na-ebuli NAD n'ahịa iji melite arụmọrụ egwuregwu.
3. Ịchọ mma ọhụrụ
Isi ihe mgbochi ịka nká:0.1% -1% NAD⁺ mgbagwoju, nwalere iji belata omimi nke wrinkle site na 37%;
Nlekọta akpụkpọ isi:Mee cell stem follicle ntutu rụọ ọrụ, tinyekwa ihe nkwalite NAD na ncha ntutu na-egbochi ntutu isi.
4. Ọrụ ugbo na nyocha sayensị
Ahụ ike anụmanụ:Ịgbakwunye NAD precursors ka ịgha nri na-abawanye ọnụ ọgụgụ nke piglets site na 15%;
Nchọpụta ndu:A na-eji oke NAD/NADH mee ihe dị ka akara nke steeti metabolic cell maka nyocha ọrịa kansa n'oge.
●Nnweta NEWGREENβ-NADNtụ ntụ
Oge nzipu: Jun-17-2025
