● Gịnị BụThiamine hydrochloride ?
Thiamine hydrochloride bụ ụdị hydrochloride nke vitamin B₁, nwere usoro kemịkal C₁₂H₁₇ClN₄OS·HCl, arọ molecular 337.27, na nọmba CAS 67-03-8. Ọ bụ ntụ ntụ kristal na-acha ọcha ma na-acha odo odo na-esi ísì ụtọ na-esi ísì ụtọ. Ọ dị mfe ịmịkọrọ mmiri na ọnọdụ akọrọ (ọ nwere ike ịmịnye mmiri 4% mgbe a na-ekpughere ya na ikuku). Njirimara anụ ahụ na nke kemịkal gụnyere:
Solubility:Na-agbaze nke ukwuu n'ime mmiri (1g/mL), na-agbaze ntakịrị na ethanol na glycerol, yana ihe na-adịghị ahụkebe na ihe mgbaze organic dị ka ether na benzene.
Nkwụsi ike:Kwụsie ike na gburugburu acidic (pH 2-4) ma nwee ike iguzogide okpomọkụ dị elu nke 140 ° C; mana ọ na-emebi ngwa ngwa na ngwọta na-anọpụ iche ma ọ bụ alkaline ma na-eme ya ngwa ngwa site na ụzarị ultraviolet ma ọ bụ ndị na-ahụ maka redox.
Njirimara nchọpụta:Ọ na-emeghachi omume na cyanide ferric iji mepụta ihe na-acha anụnụ anụnụ "thiochrome", nke na-aghọ ihe ndabere maka nyocha ọnụọgụ38.
Usoro nkwadebe bụ isi nke ụwa bụ njikọ kemịkalụ, nke na-eji acrylonitrile ma ọ bụ β-ethoxyethyl propionate dị ka ihe eji eme ihe ma na-emepụta site na condensation, cyclization, nnọchi na usoro ndị ọzọ, na ịdị ọcha karịa 99%.
●Gịnị bụ uru nkeThiamine hydrochloride ?
A na-atụgharị thiamine hydrochloride n'ụdị thiamine pyrophosphate (TPP) na-arụ ọrụ n'ime ahụ mmadụ, ma na-arụ ọtụtụ ọrụ physiological:
1. Ike metabolism isi:dị ka coenzyme nke α-ketoacid decarboxylase, ọ na-esonye na usoro ntụgharị glucose na ATP. Mgbe ọ bụ ụkọ, ọ na-eduga na mkpokọta pyruvate, na-akpata lactic acidosis na nsogbu ike.
2. Nchekwa sistemu akwara:Ịnọgide na-enwe nduzi nkịtị nke mkpali akwara. Enweghị ụkọ siri ike na-akpata beriberi, yana akara ngosi nke gụnyere neuritis mpụta, atrophy muscular, na nkụda obi. N'akụkọ ihe mere eme, o butere ọrịa na-efe efe buru ibu na Eshia, na-egbu ọtụtụ narị puku mmadụ kwa afọ.
3. Uru nyocha na-apụta:
Nchekwa myocardial:Ntinye uche 10μM nwere ike imegide acetaldehyde na-ebute mmebi mkpụrụ ndụ myocardial, gbochie ịgbalite caspase-3, ma belata nguzobe protein carbonyl.
Mgbochi neurodegeneration:N'ime nnwale anụmanụ, erughi eru nwere ike ibute mmụkọ na-adịghị mma nke protein β-amyloid na ụbụrụ, nke metụtara ọrịa ọrịa Alzheimer.
Otu dị oke egwu maka ụkọ gụnyere:eri ogologo oge nke osikapa na ntụ ọka a nụchara anụcha, ndị aṅụrụma (ethanol na-egbochi nnabata thiamine), ụmụ nwanyị dị ime, na ndị ọrịa nwere afọ ọsịsa na-adịghị ala ala.
●Kedu ihe bụ ngwa nkeThiamine hydrochloride ?
1. Ụlọ ọrụ nri (oke oke):
Ndị na-akwalite ihe oriri:agbakwunyere na ngwaahịa ọka (3-5mg / kg), nri ụmụ ọhụrụ (4-8mg / kg), na ihe ọṅụṅụ mmiri ara ehi (1-2mg / kg) iji mee ka ihe na-edozi ahụ na-efunahụ site na nhazi dị mma.
Ihe ịma aka nka nka:N'ihi na ọ dị mfe ire ere na gburugburu alkaline, a na-ejikarị ihe ndị dị ka thiamine nitrate dochie anya nri ndị e ghere eghe.
2. Ngalaba ahụike:
Ngwa ọgwụgwọ:A na-eji injections eme ihe maka ọgwụgwọ mberede nke beriberi (neurological / obi nkụda mmụọ), a na-ejikwa ọgwụ ọnụ mee ihe dị ka ọgwụgwọ inyeaka maka neuritis na afọ ntachi.
Ngwakọta ọgwụgwọ:jikọtara ya na ndị na-ahụ maka magnesium iji melite arụmọrụ nke encephalopathy Wernicke ma belata nlọghachi azụ.
3. Agriculture na biotechnology:
Ndị na-ebute ihe mgbochi ọrịa mkpụrụ osisi:Ngwọta ịta ahụhụ 50mM nke osikapa, cucumbers, wdg, na-eme ka mkpụrụ ndụ ihe nketa metụtara pathogen (genes PR), ma na-akwalite iguzogide fungi na nje.
Ihe mgbakwunye nri:Melite arụmọrụ nke metabolism shuga n'ime anụ ụlọ na anụ ọkụkọ, ọkachasị na gburugburu nrụgide okpomọkụ (mmụba agụụ maka mkpochapụ ọsụsọ).
● Ọhụụ ọhụrụ na-eweta ogo dị eluThiamine hydrochlorideNtụ ntụ
Oge nzipu: Jun-30-2025
