• Gịnị bụTUDCA ?
Ikpughe anyanwụ bụ isi ihe kpatara mmepụta melanin. Ụzarị ultraviolet na ìhè anyanwụ na-emebi deoxyribonucleic acid, ma ọ bụ DNA, n'ime sel. DNA mebiri emebi nwere ike bute mmebi na mgbapụ nke ozi mkpụrụ ndụ ihe nketa, na ọbụna mee ka mkpụrụ ndụ ihe nketa na-adịghị mma, ma ọ bụ mfu nke mkpụrụ ndụ ihe na-egbochi akpụ, na-eduga n'ọdịdị etuto ahụ.
Otú ọ dị, ikpughe anyanwụ abụghị "egwu", nke a bụkwa "kredit" nye melanin. N'ezie, n'oge dị oke egwu, a ga-ahapụ melanin, na-enweta ike nke ụzarị ultraviolet nke ọma, na-egbochi DNA imebi, si otú ahụ belata mmebi nke ụzarị ultraviolet na-akpata n'ahụ mmadụ. Ọ bụ ezie na melanin na-echebe ahụ mmadụ ka ọ ghara imebi ultraviolet, ọ pụkwara ime ka akpụkpọ ahụ anyị gbaa ọchịchịrị ma nwee ntụpọ. Ya mere, igbochi mmepụta nke melanin bụ ụzọ dị mkpa isi na-achacha akpụkpọ anụ na ụlọ ọrụ mma.
• Gịnị bụ uru nkeTUDCAna mgbakwunye egwuregwu?
Isi uru nke TUDCA bụ imeju ahụike na ọrụ imeju. Nnyocha na-akọwapụta nsonaazụ dị egwu nke mbelata enzymes imeju mgbe mgbakwunye TUDCA gasịrị. Enzyme imeju dị elu na-egosi ahụike na ọrụ imeju na-adịghị mma, ebe obere enzymes imeju na-egosi ahụike na ọrụ imeju nkịtị. Mgbakwunye na TUDCA gosipụtara mbelata dị ukwuu na enzymes imeju imeju, na-anọchite anya ahụike imeju ka mma.
Ọganihu ndị a na ahụike imeju bụ ihe na-eme TUDCA nwere mmetụta dị ukwuu maka ndị na-eji ihe anabolic, ọkachasị ihe anabolic ọnụ. Ihe ndị a nwere ike inwe mmetụta dị ukwuu na ahụike na ọrụ imeju anyị, na ịṅụ ihe mgbakwunye nkwado okirikiri ka a na-atụ aro mgbe niile na mgbakwunye na nyocha ọbara mgbe niile iji nyochaa ahụike. A na-ewere TUDCA dị ka otu n'ime ihe mgbakwunye ahụike imeju kachasị mma dị taa.
TUDCAnwere ike ichekwa mitochondria site na akụkụ cellular nke ga-ebutekarị ọgba aghara a, si otú a gbochie apoptosis. Ọ na-eme nke a site n'igbochi molecule a na-akpọ Bax ka ebuga ya na mitochondria. Mgbe a na-ebufe Bax site na cytosol gaa na mitochondria, ọ na-akpaghasị akpụkpọ ahụ mitochondrial, nke na-amalite usoro ihe omume a. Site na igbochi Bax na TUDCA, ọ ga-egbochi njikọ nke akpụkpọ ahụ cell, nke na-egbochi ntọhapụ nke cytochrome c, nke na-egbochi mitochondria ka ọ rụọ ọrụ caspases. TUDCA na-egbochi ọnwụ cell site na ichekwa akpụkpọ ahụ mitochondrial cell.
TUDCA na-egbochi ọnwụ cell site na ichekwa akpụkpọ ahụ mitochondrial cell site na ihe ndị na-emerụ ahụ. Usoro a na nzaghachi anụ ahụ bụ ihe mere nyocha na-eleba anya na uru nke ịgbakwunye na TUDCA maka ndị nwere nsogbu akwara ozi dị ka ndị ọrịa Parkinson, Huntington, Alzheimer na ALS. Nsonaazụ nke ọmụmụ ndị a na aro ndị mbụ na-atọ ụtọ nke ukwuu. TUDCA nwere ike inwe mmetụta bara uru na ọtụtụ ọrịa ndị bụ isi.
Nnyocha egosiwokwa na TUDCA na-eme ka mmetụta insulin dịkwuo mma na akwara na imeju, ma nwee mmetụta dị mma na ahụike thyroid.
• Ego oleTUDCAkwesịrị iwere?
A mụọla usoro ọgwụgwọ dị iche iche maka uru nke TUDCA. Malite na 10-13 mg nke TUDCA supplementation kwa ụbọchị, ndị ọrịa nwere ọrịa imeju na-adịghị ala ala nwetara mbelata dị ukwuu na enzymes imeju maka ọnwa 3. Egosipụta doses ruru 1,750 mg kwa ụbọchị bara uru maka ọrịa imeju nwere abụba ma melite akwara na imeju insulin. Anụmanụ ndị a mụrụ gosipụtara doses ruo 4,000 mg (ha nhata nke mmadụ) nwere mmetụta dị mma na neuroprotection site na mfu ebe nchekwa metụtara afọ.
N'agbanyeghị oke doses ndị a, n'etiti 500 mg na 1,500 mg kwa ụbọchị yiri ka ọ bụ ezigbo dose iji mepụta mmetụta nke TUDCA. Ọtụtụ ihe mgbakwunye na-egosi na a haziri ya ka ọ nwee 100 - 250 mg nke TUDCA kwa ozi, a ga-ewere ya ọtụtụ ugboro kwa ụbọchị. Dị ka ọ dị n'ọtụtụ n'ime ihe ndị a, a chọkwuru nyocha iji nweta ọnụọgụ ụfọdụ akọwapụtara.
• Mgbe kwesịrịTUDCAa ga-ewere?
Enwere ike iwere TUDCA n'oge ọ bụla n'ụbọchị, a na-ewerekwa ya na nri kacha mma iji nyere aka ịmịnye ya. Dị ka e kwuru n'elu, ọtụtụ ihe mgbakwunye na- dosed na 100 - 250 mg kwa na-eje ozi. A na-atụ aro ka ịgbasa usoro ọgwụgwọ TUDCA n'ụbọchị dum, na-ewere ya 2, 3, 4 ma ọ bụ ọbụna ugboro 5 kwa ụbọchị.
• Ogologo oge ole ka ọ na-ewe maka TUDCA ịrụ ọrụ?
TUDCA anaghị arụ ọrụ n'otu abalị. Nnyocha egosiwo mmetụta dị iche iche nke TUDCA mgbe 1, 2, 3 ma ọ bụ ọbụna ọnwa 6 nke mgbakwunye. Site na nyocha dịnụ, ọ dị mma ịsị na ọ dịkarịa ala ụbọchị 30 (ọnwa 1) nke mgbakwunye chọrọ iji hụ nkwalite na uru. Agbanyeghị, iji ya na-aga n'ihu na ogologo oge ga-eweta uru kachasị ukwuu site na ịgbakwunye na TUDCA.
Oge nzipu: Dec-06-2024
