●Gịnị bụ Sodium 3-Hydroxybutyrate ?
Sodium 3-hydroxybutyrate (sodium β-hydroxybutyrate, BHB-Na) bụ isi ihe na-emepụta ketone ahụ mmadụ. Ọ dị n'ọbara na mmamịrị, ọkachasị n'ọnọdụ agụụ ma ọ bụ obere carbohydrate. The omenala nkwadebe dabeere na hydrolysis nke 3-hydroxybutyric acid esters (methyl ester / ethyl ester) na sodium hydroxide, ma ọ na-achọ organic mgbaze recrystallization, nke na-eduga ná mgbagwoju usoro, mfe iru mmiri absorption na agglomeration nke ngwaahịa, na ihe fọdụrụ ihe mgbaze nwere ike imetụta nchekwa nke ọgwụ ngwa.
Ka ọ dị ugbu a, ụfọdụ ụlọ ọrụ emeela ọganihu na mmepụta ihe ọhụrụ: a na-achịkwa ihe ndị na-adịghị ọcha nke crotonic acid n'okpuru 16ppm site na methanol-acetone fractional crystallization method, na ịdị ọcha na-abawanye ruo 99.5%, nke na-ezute ọkọlọtọ injection;
Teknụzụ kristal nke otu nzọụkwụ nke ihicha ịgba na-eji 160 ℃ ikuku dị ọkụ iji gbanwee mmiri mmiri mmeghachi omume ka ọ bụrụ microcrystals okirikiri, yana mkpụrụ ngwaahịa karịa 95%. Ihe ngosi diffraction X-ray na-egosi ọnụ ọgụgụ dị elu nke 17 (2θ=6.1 °, 26.0 °, wdg), na nkwụsi ike nke ihe owuwu kristal dị okpukpu 3 karịa nke usoro omenala, nke na-edozi kpamkpam nsogbu absorption nke mmiri.
●Kedu ihe bụUruNke Sodium 3-Hydroxybutyrate ?
Dị ka “molekul mmanụ dị ukwuu”, sodium 3-hydroxybutyrate na-enye ike ozugbo site na mgbochi ụbụrụ ọbara, na usoro ọmụmụ ya ka enyochala nke ọma n'afọ ndị na-adịbeghị anya:
Iwu Metabolic:N'ụdị ọrịa shuga, ọ na-eme ka mmetụta insulin dịkwuo mma. Otu dose (0.2 mg / kg) nwere ike ime ka ọnụọgụ glycogen imeju mụbaa site na 40%;
Nchekwa Neuro:Nnyocha achọpụtala na 3-hydroxybutyrate methyl ester nke na-emepụta ya nwere ike ime ka ọwa L-ụdị calcium rụọ ọrụ, mee ka ntinye calcium ion dị na mkpụrụ ndụ glial site na 50%, ma gbochie apoptosis cell site na 35%, na-enye ụzọ ọhụrụ maka ọgwụgwọ ọrịa Alzheimer;
Anti-inflammatory na antioxidant:Site n'ibelata peroxides lipid na ụdị oxygen na-emeghachi omume (ROS), ọ na-ebelata mbufụt nke anụ ahụ mgbe mgbatị ahụ gasịrị, arụmọrụ ntachi obi nke ndị egwuregwu na-abawanye site na 22% mgbe emejuchara ya.
●Kedu ihe bụNgwaNkeSodium 3-Hydroxybutyrate ?
1. Ụlọ ọrụ ahụike: Isi ihe na-ebu Ketogenic Economy
Ijikwa ibu arọ: dị ka isi ihe na-emepụta ketogenic, ọ na-akpali arụmọrụ ketogenic imeju.
Egwuregwu oriri na ọṅụṅụ: electrolyte ọṅụṅụSodium 3-Hydroxybutyratejikọtara ya na amino acid nwere yinye alaka nwere ike idowe mkpokọta ketone ọbara karịa 4mM mgbe emegasịrị ahụ ma belata oge mgbake ahụ site na 30%.
2. Ubi Ahụike: Olileanya Ọhụrụ Maka Ọrịa Neurodegenerative
Adjuvant ọgwụgwọ nke Akwụkwụ na-adọ: jikọtara ya na anticonvulsants nwere ike ibelata ugboro nke ọdịdọ site 30%, na agba III ụlọ ọgwụ ebidola;
Usoro nnyefe ezubere iche: Cy7 fluorescent labeled probes na-enweta na tracing vivo, na onyonyo infrared dị nso na-egosi na ọ bara ụba na hippocampus n'ime awa 2, na-enye onye na-ebu maka nchịkwa ọgwụ ụbụrụ.
3. Sayensị Akụrụngwa: Isi ihe dị ndụ na-ebute mmetọ ọcha
Plastics biodegradable: Copolymerized na polyester aromatic ka ọ bụrụ PHB (poly 3-hydroxybutyrate), na ebe mgbaze nke 175°C yana ikuku oxygen nke naanị 1/10 nke PET. Enwere ike imebi ya kpamkpam na ala anaerobic n'ime ụbọchị 60. Guangdong Yuanda New Materials Co., Ltd. enwetala mmepụta ọkwa ọkwa mmepụta ihe;
Ihe nkiri ọrụ ugbo na-agbasa: PE mulch na 5% sodium 3-hydroxybutyrate agbakwunyere, nke na-efunahụ akụrụngwa ya n'otu oge mgbe ejiri ya mee ihe, ọ nweghịkwa microplastic residues mgbe composting gasịrị.
●Ọdịmma dị elu NEWGREENSodium 3-Hydroxybutyrate Ntụ ntụ
Oge nzipu: Jul-17-2025
