●Gịnị bụL-Citrulline?
L-Citrulline bụ α-amino acid na-abụghị proteinogenic, aha ya bụ ndị ọkà mmụta sayensị bụ ndị mbụ kewapụrụ ya na mmiri ọkụ (Citrullus lanatus) juice na 1930. Aha chemical ya bụ (S) -2-amino-5-ureidopentanoic acid, nke nwere usoro molecular nke C₆H₁₃N₆H₁₃N1. Nọmba CAS nke 372-75-8237. Mmepụta ụlọ ọrụ ọgbara ọhụrụ na-esite n'ụzọ abụọ:
Mwepụta eke: dịpụrụ adịpụ site na osisi cucurbitaceae dị ka anyụ na kukumba, ma na-arụ ọrụ dị ala na ọnụ ahịa dị elu;
Biosynthesis: ọgbọ nke catalytic na okirikiri urea na-eji ornithine na carbamoyl phosphate dị ka mkpụrụ, ma ọ bụ ntụgharị oxidative nke arginine n'okpuru ọrụ nke nitric oxide synthase (NOS).
Njirimara anụ ahụ na kemịkalụnke L-Citrulline :
Njirimara na solubility: ọcha crystalline ntụ ntụ, ubé utoojoo uto; mfe soluble na mmiri (solubility 200g / L, 20 ℃), fọrọ nke nta insoluble na organic solvents dị ka ethanol na ether;
Njirimara anya: ntụgharị kpọmkwem + 24.5 ° ~ + 26.8 ° (c = 8, 6N HCl), nke bụ isi ihe na-egosi njirimara nke eziokwu;
Nkwụsi ike ntụpọ: mmetụta nke ìhè na okpomọkụ, agbaze ebe bụ 214-222 ℃ (dị iche iche crystal ụdị), mfe decompose n'elu 100 ℃; a ga-emechi ya ma chekwaa ya na ọkụ na obere okpomọkụ (0-5 ℃);
Ụkpụrụ njikwa ogo: ngwaahịa ọgwụ-ọkwa chọrọ ọla dị arọ ≤10ppm, ọdịnaya mmiri ≤0.30%, na ihe mgbanye ọkụ ≤0.10% (AJI92 ọkọlọtọ).
●Kedu ihe bụUruNkeL-Citrulline ?
Isi uru nke L-citrulline dabere na ikike ya ịtụgharị n'ime arginine ma hapụ nitric oxide (NO), si otú a na-eme ka ọtụtụ mmetụta physiological rụọ ọrụ:
Nchekwa obi
Weghachite nrụgide vaskụla ma kwalite mmụba ọbara site na izu ike nke akwara vaskụla na-emekọrịta ihe;
Nnyocha nke Mahadum Texas A&M dị na United States kwadoro na usoro mmetụta vasodilatory ya yiri "Viagra eke", yana mmụba nke 40% maka arụrụ arụ erectile na enweghị mmetụta ọgwụ.
Metabolism na Immune Regulation
Na-akwalite okirikiri urea imeju, mee ka metabolism amonia dịkwuo elu, ma belata mkpokọta amonia ọbara;
Na-abawanye ọrụ macrophage ma kwalite ikike mgbochi nje (dị ka ọnụọgụ nje influenza mụbara site na 35%).
Ụbụrụ na moto arụ ọrụ
Gafee ihe mgbochi ụbụrụ ọbara ka ọ bawanye ọkwa NO na ụbụrụ ma welie ikike iweghachite ozi ebe nchekwa;
Wepụ ụdị oxygen na-emeghachi omume (ROS) site na mmega ahụ ma gbasaa oge ntachi obi akwara site na 22%.
●Kedu ihe bụNgwaOf L-Citrulline?
1. Ụlọ ọrụ ahụike:
Ngwaahịa na-edozi ahụ nke egwuregwu: jikọtara ya na amino acid nke nwere eriri, a na-edobe mkpokọta ketone ọbara mgbe mgbatị ahụ gasịrị karịa 4mM, na oge mgbake ahụ na-ebelata site na 30% (oke ahịa zuru ụwa ọnụ na 2024 bụ 45%);
Ọrụ mmekọ nwoke na nwanyị na-emeziwanye: citrulline nwere ike ịkwalite vasodilation ma melite arụ ọrụ erectile
2. Ụlọ ọrụ nri:
Ihe nchekwa eke: na-egbochi mgbasa nke microorganisms na ngwaahịa anụ mmiri, yana ọnụ ọgụgụ nke salmon refrigerated na-ebelata site na 90%;
Ihe mgbakwunye na-arụ ọrụ: "L-Citrulline + γ-aminobutyric acid" yogọt na-arụ ọrụ, na-achịkwa nrụgide vaskụla na nchekasị.
3. Ọgwụ nje:
Ọgwụgwọ ọrịa Alzheimer: mee ka ụzọ cAMP/PI3K-Akt rụọ ọrụ, kwalite nkwupụta nke ụbụrụ na-enweta neurotrophic factor (BDNF), ma kwalite mmụta na ikike ncheta nke ụmụ oke ụdị site na 40%;
Sistemụ nnyefe mkpụrụ ndụ: dị ka pDNA nanocarrier, arụmọrụ nfefe dị okpukpu 100 karịa nke liposomes, ọ ga-abanyekwa na nnwale ụlọ ọgwụ nke Phase I maka ọgwụgwọ ụbụrụ ụbụrụ na 2025.
4. Ịchọ mma Innovation
Ejikọtara ya na moisturizers polysaccharide, ịdị irè nke ọgwụgwọ akpụkpọ anụ karịrị 80%;
Na-egbochi nnyefe nke mgbaàmà akwara na dermatitis pruritic ma na-edozi ọrụ mgbochi nke stratum corneum.
●Ọdịmma dị elu nke NewgreenL-CitrullineNtụ ntụ
Oge nzipu: Jul-16-2025
