Glutathione: Antioxidant siri ike

●Gịnị bụGlutathione ?

Glutathione (GSH) bụ ngwongwo tripeptide (usoro ihe omimi C₁₀H₁₇N₃O₆S) mebere site na glutamic acid, cysteinenkena glycine jikọtara yaγ- amide bond. Isi ya na-arụ ọrụ bụ otu sulfhydryl (-SH) na cysteine, nke na-enye ya ike ibelata ike.

Abụọ isi physiological ụdị glutathione:

1. Mbelata glutathione (GSH): ihe karịrị 90% nke ngụkọta ego n'ime ahụ ma bụrụ isi ụdị nke ọrụ antioxidant na detoxification; ozugbo na-ewepu free radicals ma na-echebe mkpụrụ ndụ site na mmebi oxidative.

2. Oxidized glutathione (GSSG): kpụrụ site na oxidation nke mkpụrụ ndụ abụọ nke GSH (GSSG), na-adịghị ike physiological ọrụ; n'okpuru catalysis nke glutathione reductase, ọ dabere na NADPH ka ewelata ya na GSH iji nọgide na-enwe nguzozi redox cell.

●Gịnị bụ uru nke TheGlutathione ?

1. Isi Ọrụ Physiological

Detoxification na nchebe imeju:

Glutathione nwere ike ckpochapu ọla dị arọ (lead, mercury), nsị ọgwụ (dị ka cisplatin) na metabolites mmanya. Ịgba ọgwụ mgbochi nke 1800mg / ụbọchị nwere ike ime ka ọrụ imeju dịkwuo mma, ọnụ ọgụgụ dị irè nke ọgwụgwọ ọrịa imeju na-egbu egbu karịrị 85%.

Enyemaka mgbochi tumor:

Glutathione nwere ike rna-akwalite nephrotoxicity chemotherapy, mụbaa ọrụ nke mkpụrụ ndụ na-egbu egbu (NK cell) ugboro abụọ, ma gbochie nrụgide oxidative tumor cell.

Nchekwa Neurological na ophthalmic:

Glutathione nwere ike rwepụ ihe mgbaàmà mbụ nke ọrịa Parkinson ma belata dopamine neurotoxicity; Ntinye n'ime mpaghara nke ntanye anya nwere ike ịrụkwa ọnya corneal ma gbochie mmepe nke cataracts.

2. Ngwa ahụike na ịma mma

Usoro mgbochi mgbochi ịka nká: Mee ka protein Sirtuins rụọ ọrụ ma gbuo oge telomere dị mkpụmkpụ; kwalite ọrụ lymphocyte ma belata ntọhapụ nke ihe ndị na-akpasu iwe;

Ịcha ọcha na iwepụ ntụpọ: gbochie ọrụ tyrosinase ma belata mmepụta melanin. Achọpụtara na ụlọ ọgwụ iji meziwanye ngbanwe akpụkpọ ahụ ma belata omimi nke wrinkle site na 40%.

●Gịnị bụ ngwa ahụsNke Glutathione ?

1. Medical Field

Injection: eji maka chemotherapy nchebe (1.5g/m² dose), nnukwu enyemaka mbụ na-egbu egbu, na ọ dị mkpa ka echekwara ya pụọ ​​​​na ìhè;

Nkwadebe ọnụ: iji ogologo oge (200-500mg / oge, karịa ọnwa 6) iji mee ka nchekwa GSH dị na ahụ dịkwuo elu ma nyere aka n'ịgwọ ọrịa imeju na-adịghị ala ala.

2. Nri na-arụ ọrụ

Ihe mgbakwunye antioxidant: vitamin C (500mg vitamin C kwa ụbọchị nwere ike ịbawanye ọkwa GSH site na 47%) ma ọ bụ selenium iji welie ihe mgbochi;

Hanover na nri nchebe imeju: agbakwunyereglutathionena-arụ ọrụ ihe ọṅụṅụ na-eme ngwangwa mmanya metabolism na ibelata imeju mmebi.

3. Ịchọ mma Innovation

Isi ihe na-acha ọcha: a na-ejikarị eme ihe n'ahịa Eshia iji gbochie melanin, yana teknụzụ microneedle iji meziwanye ntinye anụ ahụ;

Usoro mgbochi ịka nká: Liposome encapsulated GSH na-eguzogide mmebi ultraviolet ma na-ebelata fotoaging erythema site na 31%-46%.

4. Ngwa nke Teknụzụ Na-apụta

Mbufe ọgwụ ezubere iche: Nanogels na-anabata GSH nwere ike ịhapụ ọgwụ chemotherapy (dị ka doxorubicin) na saịtị etuto ahụ, na-emeziwanye arụmọrụ yana ibelata mmetụta;

Nchedo gburugburu ebe obibi na ọrụ ugbo: Zụlite ihe ndị nwere ike imebi ihe ma chọpụta ihe mgbakwunye nri iji kwalite mgbochi anụ ụlọ na anụ ọkụkọ.

Site na patent nke mmịpụta yist na-emepụta ọtụtụ puku tọn na usoro ihe ọmụmụ sịntetik taa, usoro mmepụta ihe nke glutathione ekwenyela na mgbanwe nke "onye nlekọta cell" na "engine teknụzụ". N'ọdịnihu, na mmezu nke nkwenye ụlọ ọgwụ nke ihe ngosi ọhụrụ nke neuroprotection na mgbochi ịka nká, mkpụrụ ndụ antioxidant a na-ebu ndụ ga-anọgide na-enye ọganihu sayensị maka ahụike na ogologo ndụ mmadụ. 

●Nnweta NEWGREENGlutathione Ntụ ntụ